Rothstein Lab @Rothstein_Lab
Dr. Jeffrey Rothstein is a professor of neurology and neuroscience @HopkinsMedicine and is the founding director of @packardcenter. (trainee run) rothsteinlab.org Baltimore, MD Joined April 2023-
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Quantitative Profiling of Nanoscopic Protein Aggregates Reveals Specific Fingerprint of TDP-43-Positive Assemblies in Motor Neuron Disease doi.org/10.1002/advs.2…
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Prematurely Aged Human Microglia Exhibit Impaired Stress Response and Defective Nucleocytoplasmic Shuttling of ALS Associated FUS onlinelibrary.wiley.com/doi/10.1111/ac…
SpliPath enhances disease gene discovery in case-control analyses of rare splice-altering genetic variants sciencedirect.com/science/articl…
Single-nucleus transcriptome atlas of orbitofrontal cortex in ALS with a deep learning-based decoding of alternative polyadenylation mechanisms cell.com/cell-genomics/…
Cardiac Troponin T in Tofersen-Treated SOD1 ALS Patients: Beginning to Resolve the Catch-22 of Identifying Treatment Responsive Biomarkers in ALS Drug Development onlinelibrary.wiley.com/doi/abs/10.100…
Comparative snRNAseq study of C9orf72, SOD1, and sALS spinal cord biorxiv.org/content/10.110…
HDAC6 and TDP-43 promote autophagy impairment in amyotrophic lateral sclerosis sciencedirect.com/science/articl…
Network dysfunction precedes neurodegeneration in a dox-regulatable TDP-43 mouse model of ALS-FTD. jneurosci.org/content/early/…
Can non-pharmacological interventions change levels of neurofilament light in older adults at risk of dementia? A secondary analysis of the SCD-Well randomized clinical trial sciencedirect.com/science/articl…
Generation of Astrocyte-Selective Cre Driver Lines With Distinct Onsets of Recombination Activity During Development onlinelibrary.wiley.com/doi/abs/10.100…
Cryptic splicing in synaptic and membrane excitability genes links TDP-43 loss to neuronal dysfunction biorxiv.org/content/10.110….
Rothstein Lab retweeted
C9orf72 ALS‐causing mutations lead to mislocalization and aggregation of nucleoporin Nup107 into stress granules febs.onlinelibrary.wiley.com/doi/10.1002/18…
Decoding ATXN2 Phosphocode: Structural Insights and Therapeutic Opportunities in Disease link.springer.com/article/10.100…
Rothstein Lab retweeted
CSF total tau as a proxy of synaptic degeneration nature.com/articles/s4146…
Neurofilament light chain dynamics in the pre-symptomatic phase of amyotrophic lateral sclerosis: a case report tandfonline.com/doi/abs/10.108…
Metformin decreases RAN proteins, rescues splicing abnormalities and improves behavioral phenotypes in SCA8 BAC mice biorxiv.org/content/10.110…
Multi-modal comparative phenotyping of knock-in mouse models of frontotemporal dementia/amyotrophic lateral sclerosis journals.biologists.com/dmm/article/18…
TARDBP (TDP-43) Knock-in Zebrafish Display a Late-Onset Motor Phenotype and Loss of Large Spinal Cord Motor Neurons onlinelibrary.wiley.com/doi/10.1002/an…
Cortical hyperexcitability drives dying forward amyotrophic lateral sclerosis symptoms and pathology in mice sciencedirect.com/science/articl…
Rothstein Lab retweeted
Endolysosomal dysfunction impairs proteostasis and induces neurodegeneration in vivo cell.com/iscience/fullt…
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