Plate Lab @Plate_Lab
Developing mass spectrometry and chemical biology tools to study dynamic protein interactions at @VanderbiltChem. This is a trainee run account. plate-research.org Nashville, TN Joined March 2019-
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Congratulations @EliFritzMcD !
Congratulations @EliFritzMcD !
Good morning Phoenix. Looking forward to attending #NACFC2023. If you’re around, come to the lunch roundtable on Proteomic-driven Advances in Studies of CF (RT29) where we’ll discuss the latest mass spec research on CF. @CF_Foundation
Congrats @Dongsheng_Han1 and @JaredNordman! Glad that @J_P_Davies and our lab could contribute to this exciting paper.
We concluded translational dynamics modulate the co-translational folding of P67L sufficiently to sensitive it to VX-445. Personalized medicine will need to account for system level changes beyond single point mutations in targets.
Attenuating global translation with low doses of cycloheximide (CHX) also reversed P67L VX-445 response.

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