Rossjohn lab @RossjohnLab
Led by Prof @Jamie_Rossjohn FRS we are focused on understanding molecular bases underpinning protective and aberrant immunity rossjohnlab.com Monash University, Australia Joined July 2014-
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Congrats to PhD student, Liam Rashleigh, whose 1st authored paper on gd T cell receptor recognition was published today @Structure_CP cell.com/structure/full… #GDTcellclub @MonashUni @RossjohnLab
Early bird registration pricing for CD1-MR1 2025 ends this Friday, 6th June! Get on it 👉👉 cd1mr1.com
Congrats to Hien, 1st author of this study that arose from her hard work during her PhD.
In collaboration with Moody lab, latest paper from @RossjohnLab describing the structure of a lipopeptide bound to a MHC-I like molecule found in chickens - hopefully this study will not ruffle too many feathers.
Your immune system gradually loses it top team players when we get older 👱➡️👵 Our study in @eBioMedicine investigates how long our good immune cells stay around – a 🧵⬇️ go.unimelb.edu.au/4sep @CvandeSandt @KatherineKedz @TheDohertyInst #Influenza #AgingResearch
Our latest paper demonstrating the potential of “our” DOT cells against colorectal cancer has just been published in @NatureCancer: rdcu.be/ehYwG Many congrats to the whole team, especially @RafaelBlancoDom! :)
Recent paper from lab describing a peptide-independent MHC-restricted T cell receptor nature.com/articles/s4146… in collaboration with La Gruta lab @MonashUni @Monash_FMNHS @RossjohnLab @NatureComms
In collaboration with @NicoleLaGruta1 and colleagues, latest paper from @Jamie_Rossjohn lab describing role of Lck-coreceptor assocation in T cell function. @MonashUni science.org/doi/10.1126/sc…
Researchers in Science #Immunology have identified CD8+ T cells from human donors that can recognize naturally occurring influenza variants spanning more than 100 years, including the 1918 influenza A and 2024 #H5N1. @Jamie_Rossjohn @kedzierskalab scim.ag/4hpSzh1
🚨 Flu breakthrough! 🚨 Researchers at @TheDohertyInst & @MonashUni have discovered immune cells that recognise flu viruses even as they mutate—a further step toward a universal flu vaccine. go.unimelb.edu.au/d7z8 @UniMelbMDHS @TheRMH @oanheei @Jamie_Rossjohn @kedzierskalab…
Our latest study @SciImmunology identifies the molecular determinants of cross-reactive B35/NP418-restricted CD8+ T cells across IAVs from 1918 H1N1 to 2024 H5N1, and assesses their functionality. @KatherineKedz @RossjohnLab science.org/doi/10.1126/sc…
TCR-peptide-HLA ternary structures define molecular mechanisms of TCR cross-reactivity toward natural influenza variants @SciImmunology science.org/doi/10.1126/sc… @RossjohnLab @Jamie_Rossjohn @kedzierskalab @KatherineKedz
science.org/doi/10.1126/sc… First paper from the @JohnstoneLab for the year and a brilliant collaboration with @TheDohertyInst colleagues Dan Utzschneider and Alex Kallies. Thanks to all @PeterMacRes @PeterMacCC for help and support and great job Dane Newman and Leonie Cluse!
Ziggy enjoying park time #roughcollie
Latest paper from lab, where Awad et al describe how cigarette smoke impacts that MAIT-MR1 axis and implications for lung diseases. In collaboration with Fairlie, Hansbro and Corbett labs doi.org/10.1084/jem.20… @MonashBDI @nhmrc @WaelAwadMoh @MonashUni @Jamie_Rossjohn @JExpMed
Fast and accurate modeling of TCR-peptide-MHC complexes using tFold-TCR 1. tFold-TCR introduces a high-throughput, end-to-end method for predicting TCR-peptide-MHC (TCR-pMHC) complex structures, overcoming challenges in TCR-pMHC interactions and enabling rapid and precise 3D…
@Immutep in collab with @RossjohnLab first to publish structure of LAG-3/HLA-II complex & resolve how human LAG-3 binds to its main ligand, providing better foundation for development of blocking #LAG3 therapeutics incl its own small molecule program. bit.ly/3DkXnp2
latest paper from the lab describing crystal structure of the human LAG-3-HLA-II complex, in collaboration with @Immutep @MonashUni @SciImmunology @arc_gov_au @Jamie_Rossjohn science.org/doi/10.1126/sc…

Prof. Jamie Rossjohn @Jamie_Rossjohn
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