Cancer immunology lab @MoffittResearch investigating the role of dendritic cells and macrophages in breast and prostate cancer.labpages2.moffitt.org/ruffell/Joined March 2021
Excited to share our latest by @Triantafyllia14 where we find that IFNg acts as a metabolic switch to prune tumor-associated lymphangiogenesis and unlink immune surveillance and metastasis biorxiv.org/content/10.110…#theLundLab
#ScienceSaturday
➡️ Did you know that some chemotherapies can enhance the immune response against #cancer?
❓ How might we potentiate this?
➡️ @Ruffell_Lab and colleagues from @MoffittNews found that the necrotic cell death induced by #chemotherapy releases IL-1 alpha…
People, the IL-1 pathway is SO RELEVANT in cancer 🔥🔥 IL-1a released from dying tumor cells dampens anti-tumor immunity by recruiting immune suppressive myeloid cells - this limits efficacy of chemo and ICB
by Brian Ruffel in @Cancer_Cellcell.com/cancer-cell/fu…
Check out our latest paper “Differentiation fate of a stem-like CD4 T cell control immunity to cancer”, led by @Maria_Carden1 now live @Naturetinyurl.com/33d24k89 . This work examines how CD4 T cell differentiation dictates the outcome of the cancer response. Thread below
Our new study published today @Nature uncovers that Transgelin 2 preserves T cell lipid metabolism and anti-tumor activity. Transgelin 2 is silenced in dysfunctional TILs, and restoring its expression enhances CAR-T cell therapy in #OvarianCancer 👇nature.com/articles/s4158…
Congratulations Dr. Liu @SitemanCenter and collaborators @LabBeatty and K.Bryant on their featured article in @ScienceTM . And HUDGE THANKS to @PanCAN for bringing this team together and funding the trial that came out of the science with @verastemoncology.
Our review on a topic we eagerly enjoy exploring in the lab- how our fav immune cell types influence/are influenced by metabolic disorders preceding cancer- so much to learn! 👏🏻👏🏻 to #DanielTaranto for leading the effort, to @djkloosterman and the whole lab for their input! 🔥🔥
Our review on a topic we eagerly enjoy exploring in the lab- how our fav immune cell types influence/are influenced by metabolic disorders preceding cancer- so much to learn! 👏🏻👏🏻 to #DanielTaranto for leading the effort, to @djkloosterman and the whole lab for their input! 🔥🔥
26K Followers 2K FollowingMoffitt Cancer Center President and CEO, @MoffittNews. Tumor immunologist. Inspired leader. Girl dad. #DocsWhoRock. Driven to save more lives from #cancer.
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1K Followers 98 FollowingTumor Immunologist @NKI_nl @oncodeinstitute
interested in crosstalk between the immune system and breast cancer, metastasis, myeloid and adaptive immune cells.
537 Followers 414 FollowingPrincipal Investigator | Moffitt Cancer Center Department of Immunology | Scientific Director - Center for Antibody & Protein Engineering
18K Followers 5K FollowingExecutive Editor of Cancer Discovery @CD_AACR, published by @AACR. @BBS_Harvard/@DanaFarber alum. Native New Yorker. Views/likes/RTs are my own. She/her
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54 Followers 229 Following“Every strong woman has her own story, and hard work and perseverance make us shine 💪✨! Be who you are and live your life to the fullest!”
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343 Followers 254 FollowingMom, home cook, occasional baker, cat lover, cyclist and comms professional @MoffittNews in sunny Tampa, Florida! Admirer of alliteration. Mostly sarcastic.
252 Followers 212 FollowingVice Chair of Clinical Research and Section Chief, Breast Radiation Oncology @MoffittRadOnc @MoffittNews| Student of #BrainMets #LMD #BreastCancer
436 Followers 704 FollowingMD/PhD Student, Washington University in St. Louis. Metabolism, cancer, infectious diseases, and global health @WUSTLmstp Trainee in the DeNardo Lab
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1K Followers 98 FollowingTumor Immunologist @NKI_nl @oncodeinstitute
interested in crosstalk between the immune system and breast cancer, metastasis, myeloid and adaptive immune cells.
72K Followers 258 FollowingCancer Cell provides a high-profile forum for showcasing advances in cancer research, with a strong emphasis on translational research.
70K Followers 325 FollowingCutting-edge research in immunology from around the world. This account is no longer monitored, and content is automated. Join us on BlueSky!
537 Followers 414 FollowingPrincipal Investigator | Moffitt Cancer Center Department of Immunology | Scientific Director - Center for Antibody & Protein Engineering
18K Followers 5K FollowingExecutive Editor of Cancer Discovery @CD_AACR, published by @AACR. @BBS_Harvard/@DanaFarber alum. Native New Yorker. Views/likes/RTs are my own. She/her
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252 Followers 212 FollowingVice Chair of Clinical Research and Section Chief, Breast Radiation Oncology @MoffittRadOnc @MoffittNews| Student of #BrainMets #LMD #BreastCancer
436 Followers 704 FollowingMD/PhD Student, Washington University in St. Louis. Metabolism, cancer, infectious diseases, and global health @WUSTLmstp Trainee in the DeNardo Lab
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2K Followers 1K FollowingCell Reprogramming in Hematopoiesis and Immunity. @LuWcmm @Lund_Stem @lunduniversity. Tweets by Filipe Pereira (signed FP) and Malavika Nair (for CFP lab).
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867 Followers 356 FollowingNow on Bluesky...
Cell biologist and immunologist. Group Leader @MRC_LMB. #DendriticCells #CrossPresentation #Immunotherapy
Opinions are my own.
685 Followers 422 FollowingImmunology Group investigating how the tumour microenvironment influences the lymph node priming environment at the CRUK Scotland Institute (he/him) 🏳️🌈
465 Followers 711 FollowingProfessor. Research in the lab includes but not limited to breast cancer, tumor immune microenvironment, and targeting human cancer Treg cells. Opinions my own
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