Ruffell Lab @Ruffell_Lab
Cancer immunology lab @MoffittResearch investigating the role of dendritic cells and macrophages in breast and prostate cancer. labpages2.moffitt.org/ruffell/ Joined March 2021-
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Ruffell Lab retweeted
Interleukin-1α release during necrotic-like cell death generates myeloid-driven immunosuppression that restricts anti-tumor immunity dlvr.it/TGhVzG
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Ruffell Lab retweeted
Excited to share our latest by @Triantafyllia14 where we find that IFNg acts as a metabolic switch to prune tumor-associated lymphangiogenesis and unlink immune surveillance and metastasis biorxiv.org/content/10.110… #theLundLab
Ruffell Lab retweeted
#ScienceSaturday ➡️ Did you know that some chemotherapies can enhance the immune response against #cancer? ❓ How might we potentiate this? ➡️ @Ruffell_Lab and colleagues from @MoffittNews found that the necrotic cell death induced by #chemotherapy releases IL-1 alpha…
Ruffell Lab retweeted
People, the IL-1 pathway is SO RELEVANT in cancer 🔥🔥 IL-1a released from dying tumor cells dampens anti-tumor immunity by recruiting immune suppressive myeloid cells - this limits efficacy of chemo and ICB by Brian Ruffel in @Cancer_Cell cell.com/cancer-cell/fu…
Ruffell Lab retweeted
Online Now: Interleukin-1α release during necrotic-like cell death generates myeloid-driven immunosuppression that restricts anti-tumor immunity dlvr.it/TGJwxg
Ruffell Lab retweeted
Check out our latest paper “Differentiation fate of a stem-like CD4 T cell control immunity to cancer”, led by @Maria_Carden1 now live @Nature tinyurl.com/33d24k89 . This work examines how CD4 T cell differentiation dictates the outcome of the cancer response. Thread below
Ruffell Lab retweeted
Our new study published today @Nature uncovers that Transgelin 2 preserves T cell lipid metabolism and anti-tumor activity. Transgelin 2 is silenced in dysfunctional TILs, and restoring its expression enhances CAR-T cell therapy in #OvarianCancer 👇nature.com/articles/s4158…
Ruffell Lab retweeted
Congratulations Dr. Liu @SitemanCenter and collaborators @LabBeatty and K.Bryant on their featured article in @ScienceTM . And HUDGE THANKS to @PanCAN for bringing this team together and funding the trial that came out of the science with @verastemoncology.
Ruffell Lab retweeted
Our review on a topic we eagerly enjoy exploring in the lab- how our fav immune cell types influence/are influenced by metabolic disorders preceding cancer- so much to learn! 👏🏻👏🏻 to #DanielTaranto for leading the effort, to @djkloosterman and the whole lab for their input! 🔥🔥
Our review on a topic we eagerly enjoy exploring in the lab- how our fav immune cell types influence/are influenced by metabolic disorders preceding cancer- so much to learn! 👏🏻👏🏻 to #DanielTaranto for leading the effort, to @djkloosterman and the whole lab for their input! 🔥🔥
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