Science Translational Medicine @ScienceTM
The mission of Science Translational Medicine (AAAS) is to promote human health by communicating leading research and policy in biomedicine. science.org/journal/stm Washington, DC Joined February 2011-
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A new analysis of individuals living with #HIV reveals key sex differences in innate immune profiles and the complexity of the HIV proviral reservoir. @ragoninstitute scim.ag/4gugVGN
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New work reveals how a drop in polyunsaturated fatty acids and the enzyme #ELOVL2 correlate with vision decline in aged mice—and shows that intravitreal supplementation of PUFAs can reverse vision loss and rejuvenate the retina. @DrDorotaSK @UCIrvine scim.ag/4nriDLV
A new study of Dengvaxia recipients links afucosylated IgG antibodies to a higher susceptibility to #dengue infection after vaccination, and reveals these antibodies can enhance viral replication in mice. @LabTaia @StanfordMed @Leone1523 scim.ag/4nPjEx5
A new genome-wide #CRISPR screen identifies BACE1 as a driver of lung cancer #metastasis to the brain, suggesting that BACE1 inhibitors could be repurposed to prevent brain metastasis in #NSCLC. scim.ag/4eyJwtG #WorldCancerResearchDay
An experimental pan-KRAS inhibitor reprograms the tumor microenvironment in #PDAC and potentiates T cell infiltration, and suppresses cancer growth in mouse models while sensitizing tumors to checkpoint blockade. Learn more on #WorldCancerResearchDay: scim.ag/467qfeO
Researchers constructed a complete genome and single-cell transcriptomic atlas of the cotton rat during #RSV infection and identified various factors conserved with humans that support the model’s utility in research and therapeutic development. @ZJU_China scim.ag/4n5GxME
Why is #rifampicin effective against biofilm infections? Preclinical work shows the drug neutralizes staphylococcal biofilm infections by exploiting mutations in the Agr quorum sensing system, which normally boost drug resistance. @maicotto @NIAIDNews scim.ag/48qfGq6
A soft, robotic device can autonomously navigate the trachea to support rapid and self-guided intubation outside of hospitals and could expand and democratize intubation for emergency responders and resource-limited environments. @UCSBengineering scim.ag/47AfV1w
A new analysis of individuals living with #HIV reveals key sex differences in innate immune profiles and the complexity of the HIV proviral reservoir. @ragoninstitute scim.ag/4gugVGN
Analyzing a group of #COVID19 mRNA vaccinees in Japan, researchers identify three main types of responders based on longitudinal antibody data, providing a guide to inform future booster and vaccine strategies to protect vulnerable groups. @InterdiscipBiol scim.ag/48oSmZL
The new issue of #ScienceTranslationalMedicine is out! A clinical study identifies people at risk of renewed COVID-19 infections after mRNA vaccination, researchers probe differences in the viral reservoir between men and women living with HIV, and more. scim.ag/4gprwmk
By integrating #microglia into brain #organoids, researchers have engineered a faithful human model of myelin repair that offers a useful tool for research into demyelination disorders and myelin-regenerating therapies. @Roche scim.ag/47JNe2g
An experimental inhibitor of lysyl oxidases designed to reduce the appearance of mature scars is safe in humans and shows signs of remodeling scar skin architecture, according to new results from a phase 1 trial. @uwanews #SkinScarring scim.ag/3Ilpwij
A soft, robotic device can autonomously navigate the trachea to support rapid and self-guided intubation outside of hospitals and could expand and democratize intubation for emergency responders and resource-limited environments. @UCSBengineering scim.ag/47AfV1w
A soft robotic device could democratize emergency intubation outside of hospitals, an experimental therapy for mature scars is safe in humans in a phase 1 trial, and more in this week's issue of #ScienceTranslationalMedicine. scim.ag/4mWA32P
A new protein display platform named oPool+ offers cost-effective and scalable antibody synthesis and characterization, leapfrogging time-consuming low-throughput binding analysis and enabling rapid studies of anti-influenza antibodies. @UIUC_Biochem scim.ag/3UYH3jj
An experimental pan-KRAS inhibitor reprograms the tumor microenvironment in #PDAC and potentiates T cell infiltration, and suppresses cancer growth in mouse models while sensitizing tumors to checkpoint blockade. @Aiims1742 @KalluriLab @mcandrews_kate scim.ag/467qfeO
Dietary saturated fatty acids skew monocytes and macrophages in the lungs toward an inflammatory phenotype and exacerbate airway inflammation in mice, shows a study that decrypts the connection between diet and lung immune cell activation. @PennMedicine scim.ag/3USf9Fw
The amino acid transporter SLC38A2 is linked to a higher risk of #hypertension and can be targeted to lower blood pressure, show new experiments involving mice and an analysis of population cohorts in China and the U.K. Biobank. @ECNUER scim.ag/3HI99fK
Nature Metabolism @NatMetabolism
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Cell Reports @CellReports
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Nature Reviews Cancer @NatureRevCancer
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Science Advances @ScienceAdvances
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