Science Translational Medicine @ScienceTM
The mission of Science Translational Medicine (AAAS) is to promote human health by communicating leading research and policy in biomedicine. science.org/journal/stm Washington, DC Joined February 2011-
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The amino acid transporter SLC38A2 is linked to a higher risk of #hypertension and can be targeted to lower blood pressure, show new experiments involving mice and an analysis of population cohorts in China and the U.K. Biobank. @ECNUER scim.ag/3HI99fK
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Science Translational Medicine retweeted
We're still not finding any good evidence for a microbiome in any cancer type: see our new paper in @ScienceTM led by PhD student @YuchenGe1 science.org/doi/10.1126/sc… and the accompanying news piece, science.org/content/articl…
Science Translational Medicine retweeted
Dengue is rising. In Nepal, studying >500 #dengue patients, we found that waning immunity to Japanese encephalitis virus (#JEV) was associated with worsened dengue severity, which has implications for #vaccine campaign planning. First au🙌: @smlhtr_ science.org/doi/10.1126/sc…
A new analysis of a cohort in Nepal links the waning of vaccine immunity against Japanese encephalitis virus to elevated chymase levels and a higher risk of severe #dengue infection. @StJohnLab @dukenus @smlhtr_ scim.ag/4mY7C4c
Follicular regulatory T cells drive brain inflammation in mice with EAE by supporting the migration of inflammatory B cells from germinal centers to the brain, hinting these T cells play an important role in active #MultipleSclerosis. @N_Fazilleau @Inserm scim.ag/4g5Cs8K
Deliveries of mesenchymal stem cells accelerate the maturation of arteriovenous fistulas in a phase 1 trial and in rodents and pigs, suggesting stem cells could prevent venous stenosis in AVFs needed for hemodialysis in kidney disease. @MayoRadiology scim.ag/4g0i6gN
Spray-dried microparticles with a stabilizing polymer excipient enable ultra-high protein concentration therapeutics for subcutaneous injection, and could expand home use of these critical pharmaceuticals. @AppelGroup @StanfordMSE scim.ag/4fNCO3H
A new study reveals how S. aureus skews skin immune response toward an inflammatory IL-17 signature involving CD4+ and MAIT cells in children with RDEB, and sheds light on the link between different strains and disease severity. @Inserm scim.ag/4g1L1RO
Dietary saturated fatty acids skew monocytes and macrophages in the lungs toward an inflammatory phenotype and exacerbate airway inflammation in mice, shows a study that decrypts the connection between diet and lung immune cell activation. @PennMedicine scim.ag/3USf9Fw
Don't miss this week's issue of #ScienceTranslationalMedicine! Diets rich in saturated fats can skew immune cells in the lungs toward inflammation, an early trial suggests stem cells could facilitate dialysis for patients with kidney disease, and more. scim.ag/4mKQFtW
A new epidemiological analysis parses #dengue transmission in the Americas on a continental scale, defining synchronized seasonal and multiannual patterns in outbreaks and the influence of climatic factors such as El Niño. @majohanss @CUAnschutz scim.ag/4mRYXQy
The cholesterol drug #bezafibrate can counteract mitochondrial dysfunction and breakdowns in the #BloodBrainBarrier linked to DiGeorge syndrome, and can improve social functioning in mouse models. @Jorge_I_Alvarez @alexis_crock @pennvet scim.ag/4mZUDiq
An experimental #BaseEditing strategy for #SickleCellDisease achieves high editing efficiency in hematopoietic stem cells from healthy macaques and persists over time after autologous HSC transplant, according to a recent study. @HPKiem @fredhutch scim.ag/45hCAOx
Spray-dried microparticles with a stabilizing polymer excipient enable ultra-high protein concentration therapeutics for subcutaneous injection, and could expand home use of these critical pharmaceuticals. @AppelGroup @StanfordMSE scim.ag/4fNCO3H
Science Translational Medicine retweeted
Happy to share our article about the Synchronized dynamics of dengue across the Americas | Science Translational Medicine science.org/doi/10.1126/sc…
A new epidemiological analysis parses #dengue transmission in the Americas on a continental scale, defining synchronized seasonal and multiannual patterns in outbreaks and the influence of climatic factors such as El Niño. @majohanss @CUAnschutz scim.ag/4mRYXQy
A hemisphere-spanning study defines synchronicity and climatic influence on dengue in the Americas, polymer-stabilized microparticles enable easy injection of commercial protein therapies, and more this week in #ScienceTranslationalMedicine. scim.ag/45FHJig
The bile acid receptor FXR can enhance mitochondrial function and boost substrate oxidation in patients with #obesity when targeted with obeticholic acid, according to a new study that supports its potential as a therapeutic target. @MedUniGraz scim.ag/4oEccWJ
Why do some people living with #HIV deal with persistent viremia despite antiretroviral treatment? New research implicates autoreactive CD4+ T cells, showing that these cells produce proviruses in response to autologous antigens. @HopkinsMedicine scim.ag/41LrFua
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