Samuel D. Johnson @SDJohnsonPhD
Recently graduated PhD interested in HIV/SIV, primates, neuroimmunology, and the gut-brain axis Joined April 2022-
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Following216
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Samuel D. Johnson retweeted
The adhesion molecules β7 integrin and L-selectin contribute to cholestatic liver disease in male mice biorxiv.org/content/10.110… #biorxiv_immuno
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Samuel D. Johnson retweeted
Scientists have designed an interleukin-21 mimic with increased stability and capacity to induce more potent #antitumor activity than the native protein, which could inform improved #immunotherapies. @UWproteindesign Learn more in Science #Immunology: scim.ag/3KsvCy9
Samuel D. Johnson retweeted
New Research: Macrophages: emerging targets for ulcerative colitis frontiersin.org/articles/10.33… #FrontiersIn #Immunology
Samuel D. Johnson retweeted
A data-driven model of macrophage polarization states reveals an IFN macrophage signature in active Crohn's disease biorxiv.org/content/10.110… #biorxiv_immuno
Samuel D. Johnson retweeted
Cholesterol fuels microglia in chronic stroke go.nature.com/4nl8wrZ
Samuel D. Johnson retweeted
𝗣𝘂𝗿𝗶𝗻𝗲 𝗠𝗲𝘁𝗮𝗯𝗼𝗹𝗶𝘀𝗺 𝗣𝗮𝘁𝗵𝘄𝗮𝘆 Purine nucleic acids are normally metabolized at physiologic rates to hypoxanthine, xanthine, uric acid, and allantoin. Xanthine oxidase inhibitors (allopurinol and febuxostat) decrease uric acid levels by inhibiting the…
Samuel D. Johnson retweeted
New data identified that the short-chain fatty acid receptor GPR109A may have a protective role in #psoriasis pathogenesis and supports sodium butyrate administration or other GPR109A agonists as potential therapeutics for psoriasis. Learn more: ow.ly/uGl050WV7yA.
Samuel D. Johnson retweeted
GLP1 receptor agonists attenuate systemic inflammation through microbiota mediated enrichment of Faecalibacterium prausnitzii and ... biorxiv.org/content/10.110… #biorxiv_immuno
Samuel D. Johnson retweeted
Intestinal challenges shape the polarisation of protective dural memory CD4 T cells biorxiv.org/content/10.110… #biorxiv_immuno
Samuel D. Johnson retweeted
#Atherosclerosis #FoamCell heterogeneity 1/2 AtheroSpectrum derives 4 transcriptomically distinct Macrophage Non-inflammatory foam cell Inflammatory foam cell Inflammatory non-foamy Mφ Non-inflammatory non-foamy Mφ Foam cell high in OXPHOS, Integrin, VEGF, TGFβ, IL-3, GM-CSF…
Samuel D. Johnson retweeted
Reassessment of antibody-based detection of the murine T cell GLP-1 receptor dlvr.it/TMv6xh
Samuel D. Johnson retweeted
Nerve-associated macrophages control adipose homeostasis across lifespan and restrain age-related inflammation @NatureAging @VishwaDeepDixi1 @ElsieGonzalezH nature.com/articles/s4358…
Samuel D. Johnson retweeted
Our September issue is here! hubs.la/Q03FSgR70 Lane et al. (hubs.la/Q03FSjcP0) describe superior lipid absorption by duodenal lacteals and how it is compromised by helminths. The cover shows duodenum villi and LYVE-1+ (green) lacteals in a helminth-infected mouse.
Samuel D. Johnson retweeted
Dietary saturated fatty acids skew monocytes and macrophages in the lungs toward an inflammatory phenotype and exacerbate airway inflammation in mice, shows a study that decrypts the connection between diet and lung immune cell activation. @ScienceTM scim.ag/46bjnOQ
Samuel D. Johnson retweeted
“Our study says categorically that it’s not the medicines people have been taking for #HIV that are the culprit” for #WeightGain in people with HIV, according to Richard A. Elion, MD. More here: bit.ly/3IJvHwB
Samuel D. Johnson retweeted
New isotopic and fossil evidence suggests that early primates, including hominins, began eating grasses long before their bodies evolved the traits needed to process them efficiently—findings that support the long-hypothesized concept of behavioral drive, researchers report in…
Samuel D. Johnson retweeted
Galectin-9 is an immunotherapy target for modifying regulatory and exhausted T-cells in CLL nature.com/articles/s4146… @NatureComms
Samuel D. Johnson retweeted
Mouse lemur cell atlas informs primate genes, physiology and disease nature.com/articles/s4158… #journals #feedly
Samuel D. Johnson retweeted
Multi-omic underpinnings of Alzheimer's disease promote inflammation (particularly via T cells) whereas those for stroke relate to vascular integrity @NeuroCellPress cell.com/neuron/abstrac…
Samuel D. Johnson retweeted
Diet/microbes place the gut epithelium as a nexus for evolutionary change. With @TheSpenceLab @genomeCraig, we use #organoids to explore how evolution prepared the developing human intestine for exposure to the environment. @ScienceMagazine #evodevo 🧵1/11 science.org/doi/10.1126/sc…
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