Jason Spence @TheSpenceLab
Studying stem cells, development and disease. Opinions are my own. jasonspencelab.com Ann Arbor, Michigan Joined August 2013-
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New #organoid preprint from the Spence Lab, the Translational Tissue Modeling Laboratory (UmichTTML.org) in collab with @jonnysexton @SextonLabUM A scalable long-term in vitro model of human colonic epithelium with continuous barrier function biorxiv.org/content/10.110…
Human-mouse cross-species comparison identifies common and unique aspects of intestinal mesenchyme development biorxiv.org/content/10.110… A companion piece to our recent work from my colleague Kate Walton, led by Kelli Johnson and Xiangning Dong!
Human-mouse cross-species comparison identifies common and unique aspects of intestinal mesenchyme development biorxiv.org/content/10.110… A companion piece to our recent work from my colleague Kate Walton, led by Kelli Johnson and Xiangning Dong! https://t.co/kYHk2I9bdb
Impaired stromal-epithelial cross-talk in Hirschsprung disease highlights the risk of epithelial damage, suggesting a therapeutic option science.org/doi/10.1126/sc… @ScienceTM
Excited to share our latest preprint led by Kelli Johnson- Mapping mesenchymal diversity in the developing human intestine and organoids! We defined 5 mesenchymal populations occupying discrete anatomical locations within the human intestine. biorxiv.org/content/10.110…
🔬Advances in Precision Medicine underscore the importance of 🧬biomarker-informed care in NSCLC. Learn how upfront NGS testing can provide the most comprehensive biomarker information, while also reducing overall cost and time to results: e.lilly/3FiWnDe
Diet/microbes place the gut epithelium as a nexus for evolutionary change. With @TheSpenceLab @genomeCraig, we use #organoids to explore how evolution prepared the developing human intestine for exposure to the environment. @ScienceMagazine #evodevo 🧵1/11 science.org/doi/10.1126/sc…
Recent evolution of the developing human intestine affects metabolic and barrier functions @ScienceMagazine @GrayCampLab @TheSpenceLab science.org/doi/10.1126/sc…
We are very excited to officially launch our single cell proteomics service!! Please, check out our website if you want to work with us! sidolilab.org/single-cell
So honored to receive a BWF CAMS and thankful to all of my mentors and supporters along the way! BWF Announces 2025 Career Awards for Medical Scientists bwfund.org/news/bwf-annou…
Integrated Organoid Atlas benchmarks new protocols, even more impressive as a Highly Variable Cohort for comparison against perturbation and disease models: nature.com/articles/s4158… Lead by @_xuquan @HalleLennard Collaboration with @fabian_theis @TreutleinLab @IHB_Research
Interested in single cell genomics but need help getting started? Check out the full agenda for our Single Cell Genomics Day on Friday 4/25. All talks will be live-streamed (no registration required) at satijalab.org/scgd25
Lab’s latest: (mouse) mums grow their guts during pregnancy and lactation: cell.com/cell/fulltext/…
Organoids of human intestine made more functionally life-like with epiregulin – promoting neurons, vessel & smooth muscle cells 📷: @c_j_childs et al @TheSpenceLab @UMichMedSchool in @CellStemCell ➡️: bpod.org.uk/archive/2025/3…
Thank you to everyone who attended the 2025 RIKEN BDR-@CuSTOMOrganoids Joint Organoid Symposium, in Kobe! The last two and a half days were filled with exciting talks on the latest advancements in #organoid research. We wish everyone a safe journey home! www2.bdr.riken.jp/joint-organoid…
I truly appreciate all speakers and participants who attended the BDR-CuSTOM Organoid Symposium! See you again! @Takashima_Lab,@fu_jianping,@GrayCampLab,@AnsethGroup,@nmontlab,@TheSpenceLab,@YokokawaLab,@MasayaHagiwara,@CuSTOMOrganoids,@TakebeLab_JP,@TakebeLab,@ZornLab
I truly appreciate all speakers and participants who attended the BDR-CuSTOM Organoid Symposium! See you again! @Takashima_Lab,@fu_jianping,@GrayCampLab,@AnsethGroup,@nmontlab,@TheSpenceLab,@YokokawaLab,@MasayaHagiwara,@CuSTOMOrganoids,@TakebeLab_JP,@TakebeLab,@ZornLab
We need new members to join our lab! Please share!
Online Now! Coordinated differentiation of human intestinal organoids with functional enteric neurons and vasculature dlvr.it/TJKM8L #stemcells
Pauses in PhD admissions at Pitt, Vanderbilt, and USC. The US will never be able to compete with authoritarian countries on a lot of dimensions. But our two biggest strengths over them were always immigration & our universities. And now we’re eroding both before our eyes.
Pitt to pause PhD admissions, following Vanderbilt and USC, because of uncertainty of NIH funding to academic universities. Who will teach and train US scientists for pharma and biotech? Should we import them from countries that do? wesa.fm/health-science…
A post over a decade in the making… 🙌beyond excited to share our work out today in @ScienceMagazine. We found that retrograde (mitonuclear) signaling regulates the identity and maturity of metabolic tissues.🧵 1/6 science.org/doi/10.1126/sc…
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