Richard G. James @ScienceRicker
Principal investigator at Seattle Children's. We study B cell development, immunological disease and response to therapy. https://t.co/qwTAcNrW55 Seattle, WA Joined December 2017-
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@slavov_n @ScienceMagazine Please take a look at this manuscript in collaboration with @ScienceRicker that also shows one should not make an assumption that transcript # is correlated to secretion of a protein. biorxiv.org/content/10.110…
New research published in @NatureComms from our co-founders Drs. @ScienceRicker and David Rawlings from @seattlechildren shows robust protein production and long-term engraftment of engineered plasma B cells. nature.com/articles/s4146… #BeBio #SCRI #Research #BCells
Very happy to see the full story out finally. We had been sitting on some of these exciting findings since 2017! (6/6)
A really cool application of Partillion Biosciences and @10xGenomics technologies to measure secreted proteins together with single cell gene expression.
A really cool application of Partillion Biosciences and @10xGenomics technologies to measure secreted proteins together with single cell gene expression.
Congratulations to @bebiopharma on the Series B! This Longwood-founded company is making progress in developing a new class of cellular medicines to help patients.
Congratulations to @bebiopharma on the Series B! This Longwood-founded company is making progress in developing a new class of cellular medicines to help patients.
Bianca Viray, a professor @UW, has been awarded the AMS Joan and Joseph Birman Fellowship for Women Scholars for the 2022–2023 academic year. An arithmetic geometer, Viray researches rational points on varieties. ➡ bit.ly/3sOzka9
Join our team! DIRECTOR OF MUTATIONAL SCANNING This person will lead a team to help bring mutational scanning methods to production scale. Terrific job opportunity with @JShendure @lea_starita Details and how to apply here: bit.ly/3tpPdVo
Until the pre-print posts, I figured I would put together a thread for those who want to see the data. Many thanks to @wilfredo_nk, @kstdenis29, @EvanCLam, @adamnitido, @NaranbhaiVivek who have been up at all hours of the night both at the bench and writing the paper! 1/16
Today we release in @biorxivpreprint a method for isolating megabase-sized, oncogenic extrachromosomal DNA from human cancer cells. A collaboration with @HowardYChang, @Jens_Luebeck, @RaeisiSiavash, Vineet Bafna, @mischellab and others. (1/n) biorxiv.org/content/10.110…
Our paper is out in @Nature! Extrachromosomal DNA molecules huddle together in cancer cells to activate oncogene expression (which we call ecDNA hubs). A great collaboration with @KatieEYost, @HowardYChang, @549nm, Zhe Liu, and others. (1/10) nature.com/articles/s4158…
B cells are nature’s medicine factories built to unleash a variety of therapeutic applications. Hear our scientific co-founders, Richard James (@ScienceRicker) & David Rawlings describe the incredible versatility of B cells. vimeo.com/646051754
Congrats to the hubs, @ScienceRicker, for cofounding @bebiopharma, over zoom, while simultaneously home schooling 6th grade! Exciting technology for the sustained delivery of protein therapeutics. Read more here ⬇️
Congrats to the hubs, @ScienceRicker, for cofounding @bebiopharma, over zoom, while simultaneously home schooling 6th grade! Exciting technology for the sustained delivery of protein therapeutics. Read more here ⬇️
Check out our paper —>
Your work started @kinglhung - we are super excited to keep it moving forward!
Your work started @kinglhung - we are super excited to keep it moving forward!
Thanks for featuring @bebiopharma Longwood-founded #celltherapy #newco nature.com/articles/d4158…
Thanks for featuring @bebiopharma Longwood-founded #celltherapy #newco nature.com/articles/d4158…
Excited to share our functional data that has helped classify VUS associated with immune dysregulation at #CIS2021 - what a great meeting! Check it out
Thrilled to announce the appointment of Joanne Smith-Farrell and Rick Morgan to the leadership team at Be Bio! businesswire.com/news/home/2021…
In new work led by @AllieGreaney, we analyze mutational escape of #SARSCoV2 from monoclonal & polyclonal antibodies in terms of RBD epitope classes (biorxiv.org/content/10.110…). Provides useful framework for conceptualizing effects of individual and combined mutations. (1/n)
Finally, enjoyable part of project was getting to build on nice prior work by @cobarnes27 @bjorkmanlab @NussenzweigL @PaulBieniasz @theodora_nyc. We’ve read & enjoyed their papers on #SARSCoV2 antibodies, so appreciated opportunity to get to extend some parts of it. (11/n)

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