Simran Motwani @SimranM08
🔬 Research scholar @ NII, India | Cracking the mitochondria–microbiota axis 🧬 and its secrets to longevity ⏳ | Tiny worms, big answers 🪱⚡ Joined October 2020-
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🚨New short paper describing a new function of RICTOR/TORC2. Led by @SimranM14914635 and @SomyaBhandari8. @NImmunology @dbt @rajesh_gokhale @DrJitendraSingh mTORC2 disruption reprograms nutrient-driven behavioral adaptations in C. elegans doi.org/10.17912/micro…
After years of experiments, late nights, and endless coffee… my PhD thesis is officially submitted! 📚✨ Here’s to tiny worms 🪱 teaching us big lessons about aging, mitochondria, and the microbiota. #ThesisSubmitted #C_elegans
New Preprint alert🚨Vit B12 from microbiota has profound effects on life history traits, including longevity, through a methionine cycle → mitophagy axis. RICTOR/mTORC2 restrains this axis to maintain normal lifespan. doi.org/10.1101/2025.0… #C. elegans #Aging #mTOR
Gene-diet interactions. Adaptive capacity to dietary B12 levels is maintained by gene-diet interaction for lifespan. B12 is key in health & life span in a kinase mutant that depends on transsulfuration. @SimranM08 @NImmunology #apwm2023
@NImmunology @UnivofDelhi @iuis_online @DayofImmunology @DBTIndia @rajesh_gokhale @deb030903 Immensely proud of @SABNAMRAHMAN3 @SimranM08 and @jasleen97 for 🥇 poster prize highlighting their work on metabolic regulation of an innate immune signalling pathway in longevity assurance and cancer #themagicofworms !
Happy to share a new #preprints from lab led by @Gautam_sarkar1. We show that activated FOXO/DAF-16 senses somatic DNA damage to arrest germline development. Thanks @NImmunology @DBTIndia @serbonline @ICMRDELHI for funding. researchsquare.com/article/rs-111…

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