Sandhya Koushika @WormlockHolmes
Cellular neurobiologist @TIFRScience Mumbai, who loves genetics, live imaging and worms. Science is fun, let's go exploring. tifr.res.in/~dbs/faculty/k… Mumbai, India Joined February 2018-
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Airport art @caantia at Kathmandhu Nepal airport coming to an @IBROorg school. IBRO is absolutely fabulous at supporting neuroscience training & education around the world (esp in countries with a small science footprint).
Interesting study @SinghviLabGlia on mechanical input for cell architecture.
Interesting study @SinghviLabGlia on mechanical input for cell architecture.
Was interesting to attend a meeting with a large number of clinicians & people working with data collected from patients. #AAICNeuro @NIMHANS_BLR
Was interesting to attend a meeting with a large number of clinicians & people working with data collected from patients. #AAICNeuro @NIMHANS_BLR
How genomic variation contribute to brain str & fn in healthy aging & neurodegenerative disease in diverse populations. Genetic risk factors in AD & FTD is still not known-we can explain almost half. @YokoyamaLabUCSF @UCSFmac in #AAICIndia @NIMHANS_BLR
Several brain disorders are unique to humans. Points out several limitations from rodents to organ-on-a-chip. Makes a strong case for brain banking. Asia has 60% of the world population with 4 brain banks, India has 1. Anita Mahadevan @NIMHANS_BLR in #AAICIndia
Neurosurgery is a craft learnt as an apprentice. Developing paradigms for surgery including risk, order of surgical tasks to develop cognitive robotics for carrying out surgery and objective means to measure surgical skill. Vikas Vazhayil @NIMHANS_BLR in #AAICIndia
Complex phenomena may not be explained by reductionist approach eg weaving as embodied cognition. Also dive in knowledge/ways of knowing & ownership of knowledge. Vivek Oak, Handloom Futures Trust in #AAICIndia @NIMHANS_BLR
1/100 children in India are blind, 40% are treatable. Presents data on rewiring & long critical period in the visual pathway even for blind 20yr olds after corrective surgery. Tapan Gandhi @iitdelhi in #AAICIndia @NIMHANS_BLR
Education, physical activity (never too late to start), social engagement, hearing loss, TBI, obesity, hypertension, diabetes, depression, air pollution, alcohol consumption, smoking & others imp for resilience/reserve for dementia @Faheem240318 @NIMHANS_BLR in #AAICIndia
Anti-amyloid treatments for AD, hope or hype? New generations of anti-amyloids are performing perhaps in part due to higher dose. However only some sub-groups show improvement. Durjoy Lahiri @neuro_kolkata in #AAICIndia @NIMHANS_BLR
Complex genetic etiology in FTD. FTD genetics in Indian FTD patients identifies mutations in LRRK2, GRN, Presenilin1 known to be altered in other neurodegenerative disorders. Subasree Ramakrishnan @NIMHANS_BLR in #AAICIndia
20% of ALS patients have cognitive deficits and several have FTD. Motor neurons are most sensitive but many other neurons and pathways are affected. A. Nalini @NIMHANS_BLR in #AAICIndia
Translation day begins w/ Pramod Pal @NIMHANS_BLR in #AAICIndia. Need based research where patients are teachers eg botulinum toxin to stop drooling in Parkinson's Disease. Modified Deep brain stimulation protocols to prevent tremors originating ectopically from cortex origin.
Significant genetic component for dementia, often cluster in families. Indian populations show the same sets of genes that are mutated as other populations but with different prevalence. Presents challenges in interpreting results. Gautham Udupi @NIMHANS_BLR in #AAICIndia
Genes, environment, epigenetics together underlie neuropsychiatric disorders. Deep dive into triplet repeat disorders in Indian populations. Genes are pleiotropic eg Bipolar patients with an identified gene who also develop dementia. Biju Vishwanath @NIMHANS_BLR in #AAICIndia
Highlights the imp of detailed record keeping esp for clinicians. Phenotype info is key for interpretation of genetic testing results. The imp of multiple analysis tools for NGS data to implement genetic testing into clinical practice. Ganesh Chauhan @NIMHANS_BLR in #AAICIndia
Biomarkers with clinical utility accessible for many. Particularly imp in India rapidly ⬆️>60yrs & ~7% at 60yrs with dementia. Lays out the difficulties & prospective of current & future tests: a panel of markers works better. Sarada Subramaniam @NIMHANS_BLR in #AAICIndia
Approaches for mild cognitive impairment, w/ MRI, genetics, risk factor profiling. Microbleed detection is an imp to monitor along with neuropsychological tests. Quantitative data imp when using disease modifying therapies. Ramshekhar Menon @sctimst_tvm in #AAICIndia @NIMHANS_BLR
Complexity in diagnosis of Fronto-temporal dementia (FTD) eg as different from Frontal variant of Alzheimer's Disease. The future needs biomarkers to supplement currents cognitive and imaging tests. Ashwani Bhat HIMS in #AAICIndia @NIMHANS_BLR
Need a paradigm shift w/ focus on pre-clinical stage of AD. PCP should rule out Vit D, TSH, B12, liver & renal function as potential treatable causes. Lack of sleep, sedentary life style are risk factors. @drsinjan @fortis_hospital in #AAICIndia @NIMHANS_BLR
Poonam Thakur @poonam_thakur6
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11K Followers 914 Following @TataMemorial @UVA @IISERPune | Curious about Cells, Art, Music & More | All opinions are personal |Santosh Chauhan @Chauhanlab_ILS
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7K Followers 2K Following Neuroscientist; Science Communicator; Kathak dancer; Mom; Dean (Graduate Studies), TIFR. Website https://t.co/tcWto5gLAbVarsha Singh PhD @VarshaS53228024
3K Followers 503 Following PI and mom. Love my kids, C elegans, microbes and Art. We study olfaction during development and disease (PD, anosmia) and odours produced by microbiomes.Gautam Menon @MenonBioPhysics
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10K Followers 1K Following Trying to understand the Developmental Biology of vertebrate limb. In BMP I trust! All tweets are personal . RTs are not endorsements.IndiaBioscience.org @IndiaBioscience
29K Followers 626 Following IndiaBioscience serves as a catalyst for facilitation and change in the life sciences ecosystem in India. Curated by @ankitarathore02.Deepak Modi @DeepakNModi
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877 Followers 429 Following Calcium signaling aficionado with interests in Cancer Biology & Skin Pigmentation. Science & Sports Enthusiast Associate Prof & DBT/Wellcome Intermediate FellowDaughter decides to give farewell diaries to her close friends. I simply couldn't stop laughing.
Sometimes, you meet giants in your field (the ones whose papers you read and admired as a trainee) who are humble, intensely curious, and pay it forward to their community. Moses exemplifies all of this.
2/2 A common question when I say so is: what about academic assessment for jobs and promotion? My answer is that academia (still) values consistent, scholarly output in reasonable journals. It is very hard to reject scholarship. Aim for this as it is under your control.
Paper out! We find that epithelia maintain glia-neuron properties under mechanical stress with animal age. A puzzle I started 12+ yrs ago got solved in my lab by @ceCe_elegans and team @fredhutch @HutchBasicSci 🧩🧬🪱🍾 Nice coverage by @NNScienceWriter: bit.ly/44kKGnl
Online now: Epithelial UNC-23 limits mechanical stress to maintain glia-neuron architecture in C. elegans dlvr.it/T61Gbb
@uramakri Congratulations on getting elected as Member of American Academy of Arts of Sciences under Evolution and Ecology amacad.org/new-members-20…
Basic neuroscientists engage researchers with exciting developments across molecular & neurobiological science (including analogies with Bengaluru traffic!) @RaviManjithaya @WormlockHolmes, Dr Soumya, Phalguni at the 1st session #AAICNeuro India meeting @alzassociation @nimhans
Beautiful images from @bewersdorflab. "Rapid multiplexed super-resolution microscopy that can, in principle, be applied to a nearly unlimited number of molecular targets": FLASH-PAINT at 3D super-resolution. cell.com/cell/fulltext/…
Huge congrats to our hard-working @PLOSBiology editorial board members @c_eroglu @SenguptaLab @uramakri @WolfnerLab and Aaron Mitchell for their well-deserved elevation to @americanacad membership! amacad.org/new-members-20…
We're very excited that three @NCBStheory faculty were among the 35 invitees to the "First Solvay Conference in Biology" organised by the International Solvay Institutes from 18-20 Apr 2024. Here's a photo of Profs. Madan Rao, Mukund Thattai & Shashi Thutupalli from Brussels!
Popping back on here to thank my mentors, colleagues and friends @BrandeisScience & elsewhere, my funders, & my very patient family. Most importantly, thank you to all the students & postdocs who chose to science along with me. And of course 🙏🏽 to our beloved worms!
Announcing our new members! The Academy is honoring excellence in an array of disciplines and professions, and inviting these new members to join our work to advance the common good. The first members were elected in 1781. Learn who was elected in 2024: amacad.org/news
@WormlockHolmes @NIMHANS_BLR Thanks, Sandhya! Appreciate your camaraderie 🇮🇳💕
Interesting thread involving author, journal and peer review service. Journal-agnostic review, distinguishing soundness vs importance, & objective assessment all sometimes more difficult than often portrayed.
@ManuelTHERY @J_Cell_Sci This is a refereed preprint that was submitted to us via @ReviewCommons. So please note that this was not a 'ridiculous' editorial decision by an 'obstructive publisher', but a post review decision based on three detailed reports. See here: biorxiv.org/content/10.110…
And this is telling. Journal editors so often blamed for demanding more work, but a nice demonstration that even in the absence of a journal or editor referees ask for this x.com/ManuelTHERY/st…
@emboreports @J_Cell_Sci @ReviewCommons Right! and the reviews were quite negative... But it is hard to review for @ReviewCommons since you don't know the expectations of the journal... reviewers keep on asking for "more", as if they were editors, instead if evaluating data acquisition and the strength of conclusions.
@arjunrajlab As I've said before, a big reason is academia's obsession with Impact Factor and PubMed. These stifle innovation, but without them there's very little chance of getting buy-in x.com/cshperspective… 1/n
@arjunrajlab @JunhyongKim @mvicaracal @rita_strack that’s fair. part of the problem is a systemic inertia. i’ve always said that Impact Factor & PubMed are the two biggest obstacles. When a publisher tries anything that doesn't have the former or can’t be accommodated by the latter, very hard to get academics on board 1/2
So honored to be included. So grateful to all of my colleagues and trainees, past and present.
Congratulations to Kristen Verhey! Kristen has been inducted as a 2023 AAAS Fellow for her distinguished contributions to the fields of cell biology and biophysics in understanding microtubules and motors, and development of the tubulin code. #accolades #cellbiology #biophysics
Read more about this research in our ‘First person’ interview with Vidur Sabharwal: journals.biologists.com/jcs/article/13…
Vidur Sabharwal @vidur_sa1, Sandhya Koushika @WormlockHolmes @TIFRScience and colleagues find that FBXB-65 regulates anterograde transport of the kinesin-3 motor UNC-104 through a PTM in a region next to the cargo binding PH domain. journals.biologists.com/jcs/article/13…
@neuronsparker @DalalSci No way!
@Spo11Rulz @DalalSci That is so cool! His lab leader shared eventual Nobel prize money with his students and that put my father/aunt/uncle through college :)
@DalalSci my grandfather was a sophomore when Thomas Hunt Morgan took him into his lab (Fly Room @ Columbia) and as a sophomore he computed the worlds 1st genetic map! sturtevant.com/sturtevant/ahs…