Anthony Stack, DO @TonyCStack
Hematologist/Oncologist | Lymphoma, BMT and Cellular Therapy | Fox Chase Cancer Center foxchase.org/anthony-stack Philadelphia, PA Joined November 2017-
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1/ New @BloodAdvances treasure trove of 🇩🇪 🇺🇸 data about bridging before CAR-T in #MMsm. Bigger is not better when it comes to bridging using chemotherapy... Worse post-CAR-T efficacy (unsurprising: tumor biology as confounder) but also clearly worse cytopenias & infections!
How I treat acute lymphoblastic leukemia in the era of immunotherapy while revisiting the myth of second remission ow.ly/VNYF50WBFRq #HowITreat #lymphoidneoplasia #transplantation
1/ As @End_myeloma has said so eloquently: "The only place where BCMA must come before GPRC5D is the dictionary." Talquetamab bridging before BCMA CAR-T in myeloma - short, very effective, and rapidly becoming my preferred approach for patients with aggressive #MMsm biology!
1/ As @End_myeloma has said so eloquently: "The only place where BCMA must come before GPRC5D is the dictionary." Talquetamab bridging before BCMA CAR-T in myeloma - short, very effective, and rapidly becoming my preferred approach for patients with aggressive #MMsm biology! https://t.co/0XvfhqNRDd
🧵 How I treat platelet transfusion refractoriness 🩸 Blood 2025 review by Nahirniak et al. 1️⃣ Definition: PR = inadequate post-transfusion platelet increment (PI ≤ 5–10×10⁹/L) on 2 occasions. 📊 CCI = (PI × BSA) / platelet dose. 2️⃣ Causes: 🔹 Immune (HLA antibodies – class I…
Early methionine availability attenuates T cell exhaustion @NatImmunol nature.com/articles/s4159…
Gemtuzumab ozogamicin in first-line treatment of CBF-AML: insights from a retrospective multi-center analysis @LeukemiaJnl nature.com/articles/s4137…
Finally. We have European regulatory approval for high risk smoldering myeloma! Await FDA decision. AQUILA trial. @NEJM Darzalex (Daratumumab)
Just out! Current Risk stratification of all Plasma Cell Disorders. MGUS, SMM, Myeloma, Amyloidosis. We paid Open Access fees so you can download and read freely! Lots of Tables. Bookmark. @ZanwarSaurabh @myelomaMD @LeukemiaJnl Link: nature.com/articles/s4137…
Reducing Pyrrhic Victories in Allogeneic Stem Cell Transplantation Posttransplantation cyclophosphamide significantly reduced graft-versus-host disease and improved survival in patients undergoing transplantation from a matched related donor. jwat.ch/3GIpaSk @NEJM
🧬 𝗝𝗼𝗶𝗻 𝘂𝘀 𝗳𝗼𝗿 𝘁𝗵𝗲 𝗻𝗲𝘅𝘁 @TheIACH 𝗣𝗼𝘀𝘁-𝗔𝗦𝗖𝗢/𝗘𝗛𝗔 𝟮𝟬𝟮𝟱 𝘄𝗲𝗯𝗶𝗻𝗮𝗿: 𝗦𝘂𝗺𝗺𝗮𝗿𝗶𝘇𝗶𝗻𝗴 𝗠𝗗𝗦 𝗮𝗻𝗱 𝗔𝗠𝗟 𝗱𝗮𝘁𝗮 𝗳𝗿𝗼𝗺 𝗘𝗛𝗔 𝗮𝗻𝗱 𝗔𝗦𝗖𝗢 🗣️ 𝘗𝘳𝘦𝘴𝘦𝘯𝘵𝘦𝘥 𝘣𝘺 𝘈𝘮𝘦𝘳 𝘡𝘦𝘪𝘥𝘢𝘯 🗓️ 𝘛𝘩𝘶𝘳𝘴𝘥𝘢𝘺, 𝘑𝘶𝘭𝘺 24, 2025 🕕…
Bispecific antibodies in diffuse large B-cell lymphoma: a new review. haematologica.org/article/view/1…
Glofitamab Combined With Pola-R-CHP or R-CHOP as First Therapy in Younger Patients With High-Risk Large B-Cell Lymphoma: Results From the COALITION Study brnw.ch/21wTQuW Authored by @AdrianMinson, @mike_dickinson1, et al. #lymsm
Fascinating! In vivo CAR T cell generation to treat cancer and autoimmune disease | Science science.org/doi/10.1126/sc…
Your research can inform, inspire, and ignite progress in #hematology! The abstract submission portal for the 67th ASH Annual Meeting and Exposition is OPEN. Share your advancements in science, translational research, or care disparities. Submit today: ow.ly/6WaQ50WisKY
One day. Zero travel. All the insights. Get the latest #bloodcancer updates from world-renowned experts without leaving your desk! Join us for Breakthroughs in Blood Cancers, chaired by @DrHKantarjian. 📅Nov 20 💻Zoom 🆓for SOHO Members Register👉sohoonline.org/SBBC #hemonc
Use of machine learning techniques to predict poor survival after hematopoietic cell transplantation for myelofibrosis ashpublications.org/blood/article-…
📢Final BELLINI results at 45.6 months follow-up show no overall survival benefit of venetoclax in the general relapsed or refractory multiple myeloma population. Post-hoc analyses suggest benefits are limited to biomarker-positive subgroups. 👇 shorturl.at/bwOYn
2025 and people still debating EPOCH in DHL.
2025 and people still debating EPOCH in DHL.
No more REMS for FDA-approved CAR-T products! Also, labeling updated for only 2 weeks in proximity to CAR center and 2 weeks no driving. #lymsm #tcellrx #mmsm fda.gov/vaccines-blood…
Today’s EHA #ThinkingThursday focuses on B-cell lymphoma classification by cell of origin. Can you fill in A, B and C? Share your answers in the comments below or swipe for the answer. Interested in #lymphoma? Check out our #lymphoma program on #EHACampus ehaedu.org/EHA-Lymphoma-P……
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