Yin Loon Lee @YLLee_CellBio
Cell biologist from 🇸🇬 @astar_research, co-founder at Nuevocor, postdoc @LabBurke, PhD @StearnsLab. Nuclear mechanotransduction, #microtubules, #RareDisease. a-star.edu.sg/asrl Singapore Joined March 2019-
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Yin Loon Lee retweeted
#Preprint alert! Check out @ConfinementLab’s new research on the role of #mechanical #memory in potentiating confined migration: biorxiv.org/content/10.110…
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Yin Loon Lee retweeted
Day 1, done and dusted! But the party is just getting started with The Hawker Center Mentorship Night at three of Singapore’s most iconic hawker centers – ABC Brickworks, Lau Pa Sat and Newton Food Center. See you there! #MBIMPG2025
Yin Loon Lee retweeted
My lab @MBIsg and @NUSMedicine is recruiting a fully-funded postdoc to start in Jan 2026! Interested in cell and tissue mechanics, transcriptional regulation of tissue health, or AI/ML for disease mechanobiology? Come join us in Singapore! mechano-medicine-lab.com/positions
Yin Loon Lee retweeted
What allows lamins A and C to confer much stronger mechanical stability to the nuclei than lamin B? We show that even though all lamins can protect the nucleus from small cell intrinsic forces, only lamin A/C protect the nucleus from large deformations: biorxiv.org/content/10.110……
Yin Loon Lee retweeted
Interested in a #postdoc on cardiac #mechanobiology? Our lab has a fully funded position via our recently awarded @HFSP grant to study the biophysical processes that build insect hearts🪲🪰🫀 Come join us @MBIsg for some cool evo-devo-mechanobio work! 👇 mbi.nus.edu.sg/jobs/seeking-p…
I am looking to hire a postdoctoral fellow to work on a collaborative project at the Mechanobiology Institute with the inimitable Sasha Bershadsky, focusing on interactions between the nucleus and the cell-ECM junctions in directed cell migration. mbi.nus.edu.sg/jobs/seeking-p…
Yin Loon Lee retweeted
Check out our lab's latest review by @MFarisHazwan @MBIsg @BME_NUS in Current Opinion in Cell Biology @sciencedirect 🔗sciencedirect.com/science/articl… We teamed up w/Brian Aguado @ucsdbe to highlight region- & sex-specificity of #ECM signaling in the aging heart!🫀 Hope you enjoy!
Yin Loon Lee retweeted
Interested in a #postdoc on nuclear #mechanobiology? We have a fully funded position in the @ConfinementLab designed to help you meet your career goals while researching the rapidly growing field of cellular #confinement. Please get in touch for more info!
Yin Loon Lee retweeted
Our heartfelt condolences to Linda and all affected by this devastating news. Prof Michael Sheetz was an inspirational Founding Director of MBI and we would not be here today without his foresight and leadership. We hope to continue his legacy in mechanobiology for years to come.
Our heartfelt condolences to Linda and all affected by this devastating news. Prof Michael Sheetz was an inspirational Founding Director of MBI and we would not be here today without his foresight and leadership. We hope to continue his legacy in mechanobiology for years to come.
Yin Loon Lee retweeted
The @ConfinementLab's latest paper is out in @PNASNews! Fantastic work by @LY_Sci to build a tool to rapidly and accurately measure nuclear volume and surface area in #confinement. Thread below: pnas.org/doi/10.1073/pn…
Yin Loon Lee retweeted
Ok looks like we’re reaching critical mass on the other place! I won’t delete this account but I’ll stop actively posting - see you over there 💙
Yin Loon Lee retweeted
👇SAVE the date 👇As the chair of the upcoming European meeting on Intermediate Filaments, I am happy to announce its launching. RT & more details to come. Thx organizing team with @BonneGisele @etiennemannevil A.Bertrand O.Agbulut #cytoskeleton @ConnectingIFs
Yin Loon Lee retweeted
This may be obvious to some but I'm now convinced: fierce competition for grants and papers is leading to low societal ROI (return on investment). Why, when competition should mean only the best-formulated and executed work is accepted for funding and high-profile publication?
Yin Loon Lee retweeted
We’re thrilled to see our artistic rendition of the keratin intermediate filament cytoskeleton highlighted on the cover of @Dev_Cell along with our paper! cell.com/developmental-…
Yin Loon Lee retweeted
Shifts in keratin isoform expression activate motility signals during wound healing cell.com/developmental-…
Yin Loon Lee retweeted
🚨 Super psyched this story is finally out! Herculean effort and 3rd chef d’oeuvre in @NatCellBio by @patriziaromani in just 5y, where we describe #mitochondrial #mechanotransduction. nature.com/articles/s4155… Megathread with bonuses ⬇︎⬇︎⬇︎
Yin Loon Lee retweeted
Congrats to Ambros and Ruvkun! Read the original papers, which appeared together in 1993: pubmed.ncbi.nlm.nih.gov/8252621/ pubmed.ncbi.nlm.nih.gov/8252622/ Back then, the finding that small RNAs - not protein - produced at one locus could control protein expression from another was big news!
Yin Loon Lee retweeted
Happy to share (time-limited) free access to our latest work @Dev_Cell by Fabian Zimmermann @LudersLab @IRBBarcelona and @sernarina @CNIOStopCancer @LlorcaLab: authors.elsevier.com/a/1jpyq_Yv6zvB… By reconstitution and #cryoEM we show how the #microtubule nucleator #gTuRC gets activated 🧵👇
Yin Loon Lee retweeted
Congrats to my friend and colleague Guosong Hong for his stunning and original discovery, published today in Science, on clearing tissues *in living animals* with a common food dye! The dye is tartrazine, used in Doritos! science.org/doi/10.1126/sc…
Yin Loon Lee retweeted
The founder and former CEO of Vertex Pharmaceuticals, Joshua Boger, was once asked: "What does it take to be a good leader in a pharmaceutical company?" Boger said, "Pharmaceutical discovery and development is the most complicated activity that humans do. Going to Mars is easy,…
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