Kevin Corbett @_KevinCorbett

Biochemist and structural biologist @UCSanDiego. Fan of @UCSDBMS and @UCSDChemBiochem. Also find me @[email protected] corbettlab.org San Diego, CA Joined January 2018

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Jonathan Pruneda @jnpruneda

a year ago

Had a blast working with @FelixRandow on this commentary for the #ubiquitin-like anti-phage defense systems described recently by @Jens_Hoer, @SorekLab, @_KevinCorbett, and teams. Give it a read! Ubiquitylation: Sword and shield in the bacterial arsenal authors.elsevier.com/c/1joCL3vVUPRm…

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Gene Yeo’s Lab at UC San Diego @yeo_lab

a year ago

Excited to share our work in collaboration with @_KevinCorbett on detecting protein-RNA interactions with RNA-base editing in situ in fixed cells and primary tissues. Congratulations @Lisa_Liang13 and Tao in our lab! Thank you @czi for the support! nature.com/articles/s4146…

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UCSD BioSciences @ucsdbiosciences

a year ago

New in @Nature: Researchers Reveal the Molecular Mechanism Behind Virus Sensing and Infection Neutralization in Bacteria bit.ly/4dSeZWj 🧵

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Amar Deep @iamamardeeep

a year ago

Out today in @Nature! I am thrilled to share our work on the PARIS immune system in its final published form. Huge thanks to my mentor, Kevin Corbett @_KevinCorbett, and my teammates. See the thread below in comment section for a quick summary! nature.com/articles/s4158…

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Jens Hör @Jens_Hoer

a year ago

Thrilled to share the final version of my postdoc project, out today in @Nature! We investigated the Bil system – a ubiquitin-like antiphage defense system – and discovered a new defense mechanism! More info in the thread below 👇 nature.com/articles/s4158…

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Jens Hör @Jens_Hoer

a year ago

If you're interested in learning even more about the Bil system, check out this amazing structural study by Lydia and Qiaozhen from @_KevinCorbett's lab, which was also published in @Nature today! nature.com/articles/s4158…

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Eray Enustun, Ph.D. @EnustunEray

2 years ago

My second “first author” paper is published by Nucleic Acids Research! We show how one of the proteins I found from the proteomics screen (Enustun et al., Nat Struct Mol Biol, 2023) is important for mRNA transfer from the phage nucleus and for their translation.

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The EMBO Journal @embojournal

2 years ago

Association of the chromatin-binding domain of the yeast HORMA-domain protein Hop1 with bent nucleosomal DNA boosts meiotic recombination initiation in specific regions of the genome Andreas Hochwagen, @_KevinCorbett and coworkers embopress.org/doi/full/10.10…

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Artem Isaev @Artem_Isaev_

2 years ago

Why do phages encode tRNAs? It aids in defeating tRNA-targeting immune systems. We provide structure and mechanism for the PARIS defense and show how it cleaves host tRNA upon trigger sensing. Stikingly, the non-cleavable tRNA of T5 supports the infection. biorxiv.org/content/10.110…

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Wiedenheft Lab @WiedenheftLab

2 years ago

Ringing in the new year with a pre-print on the PARIS defense system! This work defines how viral proteins activate PARIS-mediated tRNA cleavage and how viral tRNAs rescue infection. tinyurl.com/5x7epzxd. Also check out complementary work from the Corbett lab!