Scientek @_Scientek

Passionate about nucleic acid biotechnology. Operated by CSO of Scientek scientek.io Denmark Joined November 2011

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Scientek @_Scientek

2 hours ago

Cas9 has a built‑in “thermostat” for CRISPR memory. 🧬 When CRISPR guide RNAs are scarce (e.g., in new or reduced arrays), RNA-free Cas9 boosts spacer acquisition to rebuild immune memory. As guides accumulate, Cas9 availability decreases, slowing acquisition to prevent…

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Scientek @_Scientek

13 hours ago

In Basel for the Festival of Biologics! Ears still haven’t popped.

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Scientek @_Scientek

a day ago

Aptamers for bone health are gaining traction. 🦴🧬 A new review highlights how small DNA/RNA aptamers target bone pathways (PTH, BMPs, Wnt/β-catenin) to enhance regeneration, combat osteosarcoma, and slow osteoarthritis, avoiding off-target effects common in drugs. They’re…

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Scientek @_Scientek

2 days ago

Virus-inspired aptamers, engineered for precision. 🧬🦠 EPFL scientists developed multimeric DNA aptamers (MEDUSA) matching the 3-slot geometry of viral spike proteins, enhancing binding strength 10–1000x and reducing off-target effects—ideal for precise diagnostics and targeted…

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Chaitanya K. Joshi @chaitjo

3 days ago

Why does this stuff work? Can we just throw out 3D geometric inductive biases for 1000x less data efficient pure Transformers? Wrote my intuitions on when this works/doesn’t work: chaitjo.substack.com/p/transformers…

Andrew White 🐦‍⬛ @andrewwhite01

4 days ago

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Scientek @_Scientek

3 days ago

Alzheimer’s: promising RNA approach. 🧠🧬 Scientists used tiny circular RNA “aptamers” to calm brain inflammation in Alzheimer’s mice, reducing sticky amyloid plaques and improving memory tests. They delivered the therapy with a harmless virus either into the hippocampus or…

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Scientek @_Scientek

4 days ago

CRISPR delivery improves threefold. 🧬📦 Northwestern scientists developed DNA-wrapped lipid nanoparticles (LNP-SNAs) that deliver the full CRISPR toolkit—Cas9, guide RNA, and repair template—into cells with up to three times the efficiency of standard LNPs, reducing toxicity…

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Scientek @_Scientek

5 days ago

Open-source AI for protein design, simplified. 🤖🧬 EPFL’s BindCraft revolutionizes binder discovery, using AlphaFold2-guided design to create a few high-quality binders for targets like AAVs, CRISPR-Cas9, and allergens, achieving high success rates and rapid, one-shot results.…

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Scientek @_Scientek

6 days ago

New “3D genome organizer” tied to fertility and cancer. 🧬 Kyoto University researchers uncovered a STAG3‑cohesin complex that shapes DNA architecture in sperm‑forming stem cells; without STAG3, these cells fail to mature properly in mice, causing fertility problems. The team…

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Scientek @_Scientek

a week ago

Giant hidden DNA in our mouths. 🧬🦷 Researchers discovered large extrachromosomal DNA elements—"Inocles"—in oral bacteria, likely in 74% of people. These ~350 kb loops carry stress-response and DNA-repair genes, aiding microbial adaptation in the mouth and potentially linked to…

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Scientek @_Scientek

a week ago

Reading comic books has taught the importance of funding science. The most epic villians were researchers that were denied funding.#marvelcomics #dccomics

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Scientek @_Scientek

2 weeks ago

Smarter Food Safety with AI-Powered Electrochemical Sensors Researchers are leveraging machine learning and deep learning with electrochemical sensors to rapidly and accurately detect pathogens like E. coli, Salmonella, and Staph in real-world samples. AI enhances the design…

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Scientek @_Scientek

2 weeks ago

One of those days when your students know more than you…

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Scientek @_Scientek

2 weeks ago

Aptamers in Action: Rethinking Antivirals for Dengue 🧬🦟 Researchers are exploring aptamers to block dengue by targeting viral components like the capsid, envelope domain III, and methyltransferase, potentially halting replication. Cheaper, less immunogenic, and more consistent…

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Scientek @_Scientek

2 weeks ago

Aptamers for cancer gene therapy: precise delivery, fewer side effects. 🧬🎯 Scientists are using aptamers, tiny DNA/RNA “chemical antibodies”, to guide gene therapies straight to tumors, aiming to boost effectiveness while sparing healthy cells. The field looks promising in the…

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Scientek @_Scientek

2 weeks ago

We're exhibiting at Festival of Biologics Basel 2025! Don’t miss your chance to connect & learn about aptamers and our panels. Tell us your target! #festivalofbiologics i.snoball.it/p/3Vhyr/t/8

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Scientek @_Scientek

2 weeks ago

MAEA emerges as a DNA repair linchpin. 🧬🧩 A CRISPR-Cas9 screen flags MAEA, part of the CTLH E3 ligase complex, as crucial for maintaining genome stability under stress. When MAEA is lost, RAD51 doesn’t load properly onto DNA damage sites, weakening homologous recombination and…

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Scientek @_Scientek

2 weeks ago

A Structure-Guided Bifunctional Aptamer Mitigates Pseudomonas aeruginosa Virulence and Biofilms by Disrupting las and rhl Quorum Sensing Systems | Analytical Chemistry… aptamer-targeted intervention strategy on quorum sensing. Super interesting! pubs.acs.org/doi/10.1021/ac…