Jack Nicoludis @_jackn_
structural biology, computational biophysics, genomics, ML/AI |🏳️🌈 (my own posts and opinions) scholar.google.com/citations?user… San Francisco, CA Joined April 2015-
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KnotFold enables AlphaFold2 to correct mispredicted connectivity patterns in disulfide-rich peptides by mutating conserved cysteine residues in multiple sequence alignments to simulate protein coevolution. Read the paper: go.aps.org/4f9zmOL #MLSB @workshopmlsb
@BetterValencia Also noting that the person biking fell into the travel lane where, if there was a car/truck driving there, they would have been run over and potentially killed. Sandwiching people between two lanes of driving cars/trucks is a dangerous idea, and this bikeway should be replaced.
The Valencia center bikeway is causing head-on collisions between people, resulting in serious injuries. Mayor Breed and SFMTA should replace the center bikeway with curbside protected bike lanes or pedestrianization immediately. Please take action now: BetterValencia.com
I’ll be at @workshopmlsb at #neurips2023 this Friday and have a PhD internship position in my group this coming summer. Say hi if you are interested! roche.wd3.myworkdayjobs.com/ROG-A2O-GENE/j…
Can I simultaneously hate the Valencia center bike lane while also doubting that the removal of parking spaces on Valencia caused 80% loss of a business on Valencia? Let’s make Valencia one way with a protected bike lane and lots of parking spaces and loading zones!
Can I simultaneously hate the Valencia center bike lane while also doubting that the removal of parking spaces on Valencia caused 80% loss of a business on Valencia? Let’s make Valencia one way with a protected bike lane and lots of parking spaces and loading zones!
Thanks @SFMTA_Muni. Your design is working as intended.
Ok, so who is going to train OpenMissense to get them to change their (deep)minds about this?
Ok, so who is going to train OpenMissense to get them to change their (deep)minds about this?
What happens to the Valencia Street center cycle track when a vehicle obstructs the driving lane? Exactly what you expect. This wouldn’t happen with curbside protected bike lanes (@BetterValencia), which are better for safety, business, and climate. Please end the “experiment.”
SFMTA insists that people on bikes “share the road” with cars on Valencia while SFMTA installs its unprotected center cycle track that’s supposedly “closed.” I followed SFMTA’s guidance; look and see what it got me. The center cycle track is flawed; the rollout is almost worse.
This begs the question: what the heck was going on in this studio in the first place?? it’s been seemingly in a state of construction forever
This begs the question: what the heck was going on in this studio in the first place?? it’s been seemingly in a state of construction forever
The center bike lane on Valencia is already a disaster. The dividers between the bike lane and the car lane are a major hazard to bikers and cars have absolutely no issue going over them and into the bike lane if a car is blocking the car lane - I’ve seen it happen already
SFMTA is proposing a center bikeway for Valencia Street, sandwiching people on bikes between two lanes of driving cars. Valencia should have parking-protected bike lanes along the curb. Support the vision at actionnetwork.org/letters/valenc… or send an email using tinyurl.com/ValenciaBikeLa…
Why is San Francisco afraid of this?
Why is San Francisco afraid of this?
I’m looking for a summer intern in 2023 for the Computational Structural Biology group at Genentech! Join me in applying AI/ML and other methods to the drug discovery pipeline. We’re open to late stage undergraduates and graduate students. roche.wd3.myworkdayjobs.com/ROG-A2O-GENE/j…
The Computational Structural Biology group @genentech is hiring! Come join us as we build tools to gain deeper insight into protein structure to enable drug discovery. Reach out if you have questions! roche.wd3.myworkdayjobs.com/ROG-A2O-GENE/j…
Happy to share my new paper (arxiv.org/abs/2210.04893) with @cwcoley that introduces a new equivariant shape-conditioned generative model, SQUID, for generating chemically diverse 3D molecules in poses that fit a target shape. (1/9)
Super excited to share a big part of my postdoc work in the @AdamArkinLab where I developed a new functional genomic platform to study gene functions in gut bacteria! See thread for a brief summary. 1/n #functionalgenomics #microbiome #DNAbarcoding biorxiv.org/content/10.110…
Today I start at @genentech as a Senior Scientist in Computational Structural Biology Bioinformatics where I’ll be applying ML/AI methods to protein structure/function and contribute to drug discovery efforts! Im so grateful to all those who helped me during my search! 💙

Sergey Ovchinnikov @sokrypton
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Vega Shah @dr_alphalyrae
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UAW Local 5810 @UAW5810
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Northwestern Universi... @NorthwesternGW
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Rachel_JSA @Rachel_JSA
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David Barondeau @DavidBarondeau
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Ellie @CGulpan39751
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Ananya Mondal, Ph.D. @ananyaAPS
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Helen @duk88DjwcAjPfa
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340 Followers 595 Following PhD Candidate @CMUPittCompBio, advised by @david_koes. Interested in deep learning for molecular structures and accelerating drug discovery.
Tesherrough @tesherroug40081
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Biophysics from Cambr... @Biophysics_CUP
386 Followers 534 Following Two sister journals of biological function, structure and mechanism. QRB publishes in-depth reviews and QRB Discovery publishes original research.
bella @bella1227181
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Cong Fu @Cong_Fu_
519 Followers 1K Following CS Ph.D. Student at @TAMU Deep Learning, Graph Neural Networks, AI for Science. Previously at @UMich @DMAIglobal | Intern @FujitsuAmerica @Uber @NVIDIA
S R Vignesh @SRV25_IN
19 Followers 476 Following Research Scholar (Computational Biology) , IIT-Guwahati
Shisaez @Shisaez164070
122 Followers 7K Following
Helix BioStructures @HLXBIO
438 Followers 1K Following Helix Biostructures is a structural biology CRO providing structure-based drug design services to early-stage through Fortune 500 drug discovery companies.
Bio Balance, Inc. @bio1balance
813 Followers 2K Following The philosophy of Bio Balance is that accurate descriptions of drug-receptor interactions will lead to the development of better drugs. #biotech #pharmacology
Midhun K Madhu @midhunkres
214 Followers 817 Following Ph.D. in Science #GPCR #MDSimulation #ComputationalBiology 🇮🇳
Leigh @Leigh7784374438
7 Followers 311 Following
Patrick Lindley @launchpat
809 Followers 2K Following Science advocate. Flight, bicycle, space, and transportation enthusiast. Critical/skeptical free thinker. Nature and bird lover. Amateur astronomer. Atheist.
Pedro O. Pinheiro @pedroopinheiro
254 Followers 1K Following
Amir Gholami @AmirhoGholami
65 Followers 214 Following Protein Design/Engineering × Computational Biology × Biophysics. Fan of cool ideas
Kevin K. Yang 楊凱�... @KevinKaichuang
21K Followers 6K Following Principal Researcher in BioML @MSFTResearch (@MSRNE). He/him/他. 🇹🇼
Sergey Ovchinnikov @sokrypton
16K Followers 4K Following Scientist, Assistant Professor @MITBiology, #FirstGen, ProteinBERTologist, 🇺🇦 No Human is illegal. Moving to: https://t.co/sow6IRD3jj
Andrew White 🐦�... @andrewwhite01
27K Followers 2K Following Head of Sci/cofounder @FutureHouseSF. Prof of chem eng @UofR (on sabbatical). Automating science with AI and robots in biology. Corvid enthusiast
Frances Arnold @francesarnold
70K Followers 768 Following Innovation by evolution, Linus Pauling Professor at Caltech, Nobel Prize in Chemistry (I am an engineer of the biological world)
Michael Eisen @mbeisen
73K Followers 13K Following I science & try to make science open. Tweets do not represent my employer's views, but are always correct. My conflicts of interest https://t.co/77P0LDdz6j.
Vega Shah @dr_alphalyrae
19K Followers 4K Following AI for Life Sciences & Healthcare @NVIDIA | trained as a scientist from @JGI, @UW, @UCBerkeley | building global community @TechBi0 | views are all mine
UAW 4811 @uaw_4811
18K Followers 778 Following Locals UAW 2865 & UAW 5810 are now UAW 4811, the union of 48,000 academic workers at UC. | https://t.co/KwLRhNgof3
Chemjobber @Chemjobber
45K Followers 5K Following 1. A blog 2. Towards a quantitative understanding of the quality of the chemistry job market | #chemjobs: permanent industry/academia, #chempostdoc: postdocs
Marie Heffern @marieheffern
1K Followers 423 Following Associate Professor at UC Davis; lover of learning, risk-taking, and adventures; #profmom of two.
Local 33–UNITE HERE... @33unitehere
3K Followers 877 Following The union of graduate teachers & researchers at Yale! Part of the @unitehere family. #YaleRespectOurUnions #YaleRespectNewHaven
Sri Kosuri @srikosuri
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Jonathan Eisen @phylogenomics
63K Followers 14K Following Professor @UCDavis studying #phylogenomics & function of microbes & #microbiomes. Other: #BirdPhotography #RedSox #Type1. Past: @harvard @stanford @JohnsHopkins
GENU-UAW @nugradunion
2K Followers 1K Following A union for research and teaching assistants at Northeastern University!
Stuart Schreiber @SchreiberStuart
12K Followers 374 Following Truth-seeking scientist; equal parts Cajun, Mississippian, Irish, Hungarian.
Harmit S. Malik @HarmitMalik
44K Followers 7K Following Study genetic conflicts professionally. Try to avoid conflicts in personal life (with mixed results). @HutchBasicSci @fredhutch @HHMINEWS He/him
bryan dickinson @chembioBryan
6K Followers 1K Following chemical/synthetic biologist, Luddite trying find better ways to make molecules that do important stuff, dad, @uchicago professor of chemistry
Anne Carpenter, PhD @DrAnneCarpenter
22K Followers 2K Following Discovery in images. Enthralled by science. 5 kids. She. SAB Recursion, Quiver. Founder SyzOnc. opinions my own. https://t.co/CQCHnSAc9M
MCB_Harvard @MCB_Harvard
3K Followers 344 Following Department of Molecular and Cellular Biology at Harvard University
John Cumbers @johncumbers
17K Followers 2K Following Join @SynBioBeta - May 5-8, 2025 in San Jose: https://t.co/pL2XIEZH0R and read my weekly newsletter: https://t.co/MQhYwiU1Ls
GrowSF @GrowSF
24K Followers 120 Following GrowSF is the #1 voter guide in San Francisco, trusted by hundreds of thousands of San Franciscans. You deserve a city that works.
Andy @Shenanigans_ATL
426 Followers 101 Following
Steven Bacio 🚀 @sbuss
9K Followers 1K Following Co-founder @GrowSF, building a better San Francisco. Formerly Steven Buss, now Steven Bacio
Bilal Mahmood 馬百�... @bilalmahmood
7K Followers 1K Following Supervisor of San Francisco. District 5.
Jeffrey Kwong 鄺恩�... @MrKwong
164 Followers 145 Following K12 Educator, President @HarveyMilkClub, Parishioner @mhrsf, SF native, graduate @LowellHighSF @Harvard @HGSE @UCSD 광현용 🐾⛷️💪🏼🚴🏼💃🏻🎼🪚🔌🛼🏳️🌈
Mack, yes, That Mack @that_mc
6K Followers 1K Following This Place was called Twitter, these were my Tweets.
ASAP Discovery @asap_discovery
398 Followers 27 Following The AI-driven Structure-enabled Antiviral Platform uses open science to develop accessible antivirals to prevent pandemics and seed global antiviral discovery.
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638 Followers 406 Following @StanfordMed MD-PhD Program | Caltech '21 @caltechmten
Ava Amini @avapamini
8K Followers 403 Following principal researcher @MSFTResearch | AI for biomedicine | instructor @MITDeepLearning | alumna @MIT @Harvard
Kieran Didi @DidiKieran
874 Followers 1K Following Research scientist @nvidia and PhD Student in ML at @UniofOxford with @mmbronstein | Learned a lot @Cambridge_CL @emblebi @TBioinf @KnowlesLabCamb @BioMed_X
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231 Followers 152 Following @UCBerkeley and @UCSF Bioengineering PhD Candidate @KortemmeLab | @NSF GRFP Fellow | Cat Mom
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285 Followers 3 Following Inductive Bio accelerates compound optimization with state-of-the-art ADMET AI models and generative chemistry. https://t.co/L9IB7tkEd9
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bettersoma @bettersoma
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Prof. Nikolai Slavov @slavov_n
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Helix BioStructures @HLXBIO
438 Followers 1K Following Helix Biostructures is a structural biology CRO providing structure-based drug design services to early-stage through Fortune 500 drug discovery companies.
Matt Brezina 🌳 �... @brezina
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Kyle Grochmal @KCGrock
2K Followers 661 Following Living in San Francisco has made me a better person - just trying to give back to this city. I only tweet about bicycles and transportation.
Michael Retchin @MichaelRetchin
10K Followers 999 Following Building scientific intelligence. past: founding team @cellaritybio, ML researcher @Cornell, investor @pillar_vc, advisor @nucleateHQ
jj smith @war24182236
39K Followers 2K Following ⚠️⚠️parental advisory before you enter my Page you may see things you don’t like and you don’t agree with but this is what I see on a daily basis ⚠️⚠️⚠️
Joe Sangirardi 🌤�... @JoeSangirardi
2K Followers 2K Following elected member, @sfdemocrats / housing 🏠 transit 🚇 climate change 🌎 fighting for queer liberation @eqca 🌈 serving @alicelgbtqdems 🌾🇺🇸🌾
World Bollard Associa... @WorldBollard
198K Followers 22 Following The official Twitter account of the World Bollard Association™️. MERCH STORE - https://t.co/lGlBqCjY49
Patrick Lindley @launchpat
809 Followers 2K Following Science advocate. Flight, bicycle, space, and transportation enthusiast. Critical/skeptical free thinker. Nature and bird lover. Amateur astronomer. Atheist.
sara shortt @Shorttyshorttt
1K Followers 1K Following Queer AF. 25+years SF. Coffee achiever. Bike commuter. AZ Jew. Tweets are my own opinion & no one else’s.
Valencia Bike Lane @ValenciaBike
26 Followers 83 Following Hi, I’m a bike lane. I’m crowded, dangerous, and constantly blocked! I want a beautiful makeover 💅🏽
Streetsblog SF @StreetsblogSF
59K Followers 2K Following Covering livable streets and sustainable transportation in San Francisco and the Bay Area
Mission Local @MLNow
43K Followers 1K Following Independent, nonprofit news for San Francisco. Send tips and story ideas to [email protected]
SF Bicycle Coalition @sfbike
29K Followers 2K Following -No longer active. Find us on IG and Bluesky.- Promoting transportation justice through bicycle advocacy and by reducing the barriers to biking. 🚲 🚌 🚸
Pedro O. Pinheiro @pedroopinheiro
254 Followers 1K Following
Tess van Stekelenburg @velvetatom
5K Followers 1K Following 🚀ing up the future | partner @Lux_Capital. prev comp neuroscience research @oxford + bio @ucl.
Bruno Correia @befcorreia
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Trevor Chandler 陳�... @Trevor4SF
3K Followers 1K Following Proud San Franciscan @sfdemocrats, husband, and dog dad. Xs are my own.
Luke Bornheimer (Stre... @LukeBornheimer
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Kevin Roose @kevinroose
168K Followers 3K Following NYT tech columnist, Hard Fork co-host, high-perplexity language model. Writing a book about AGI.
Francisco Gimenez @fjeg1987
719 Followers 444 Following Investor at 8VC. Supporter of people who make things.
Alister Burt @AlisterBurt
2K Followers 1K Following ❄️🔬 cryo-EM @genentech views my own - love imaging and open source (especially 🐍) complexity is the enemy prev. @MRC_LMB @napari_imaging @IBS_Grenoble
Zoë Schiffer @ZoeSchiffer
93K Followers 1K Following Director of Business & Industry at WIRED. Author of Extremely Hardcore: Inside Elon Musk’s Twitter. Signal zoeschiffer.87
Ishan Deshpande @IshanDeshpande
238 Followers 111 Following Structural biologist & biochemist fascinated by membrane proteins. Principal Scientist at @genentech.
Zach Klein @zachklein
38K Followers 617 Following Just doing stuff. Check out the lush garden I grew in the middle of a major city: https://t.co/eRq9qeiLh3
Isomorphic Labs @IsomorphicLabs
29K Followers 75 Following We are reimagining the entire drug discovery process from first principles with an AI-first approach. Learn more: https://t.co/eC7rjmB3EZ
Kevin Cannon @multikev
4K Followers 3K Following Not active here any more. You can find me on other sites these days.