Muhammad Hanifi @_muhammadhanifi

MD/DPhil student @RDMOxford @UniofOxford. Tweets about medicine and bioengineering. Opinions are my own. 🇮🇩 🇬🇧 Oxford, England Joined July 2017

Tweets

176
Followers

132
Following

191
Likes

362

David R. Liu @davidrliu

3 years ago

Today we report in @ScienceMagazine a one-time base editing treatment for Spinal Muscular Atrophy (SMA), the leading genetic cause of infant mortality worldwide, affecting ~1 in 10,000 births. science.org/doi/10.1126/sc… PDF: drive.google.com/file/d/1H1k8AA… 1/17

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Muhammad Hanifi @_muhammadhanifi

3 years ago

A clever strategy to build a synthetic 'organelle' in prokaryotes to run a custom biological pathways. Also it started as an iGEM project! They really show you how far iGEM projects can go.

Haotian Guo @HaotianGuo_qb

3 years ago

A clever strategy to build a synthetic 'organelle' in prokaryotes to run a custom biological pathways. Also it started as an iGEM project! They really show you how far iGEM projects can go.

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Eric Smith @ESmithMDPhD

3 years ago

Our report of first-in-human GPRC5D-targeted CAR T cells for MM is out in NEJM! The trial was led by Sham Mailankody and could not be done without the amazing clinical, correlative science, stats, & cell manufacturing teams. Happy to share our bench>bedside journey 1/10

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Cedric Blanpain @CedricBlanpain

3 years ago

Fantastic study from ⁦@lab_marine⁩ on the cellular hierarchy that governs melanoma growth and metastasis demonstrated by lineage tracing. Congratulations to all the authors and very honored to be part of this beautiful study. nature.com/articles/s4158…

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Dr Lisa Nivison-Smith @LNivisonSmith

3 years ago

Are you 'Excited to share my new paper!' Harsh truth: Most people don't care 5 tips on how to tweet about your new paper to get real engagement @OpenAcademics @PhD_Genie @PhDVoice @AcademicChatter

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Dr Lisa Nivison-Smith @LNivisonSmith

3 years ago

Enjoyed this🧵? Please RT the first tweet. And follow me @LNivisonSmith if you are interested in - macular degeneration research - #WomeninSTEM - #scicomm - musings from a mother trying to survive #academia

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Omar Abudayyeh @omarabudayyeh

3 years ago

CRISPR can cut DNA and RNA, but did you ever wonder other activities might exist? Today in @biorxivpreprint, we show that the Type III-E Cas7-11 system programmably activates a nearby protease as part of microbial defense. + @jgooten @hnisimasu 🧵👇🏼biorxiv.org/content/10.110… 1/9

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David R. Liu @davidrliu

3 years ago

Today we share in @NatureProtocols detailed strategy and experimental procedures for designing and executing prime editing (and twinPE) experiments in mammalian cells. Congrats Jordan, @AlexanderASousa, Peyton, and @PeterJ_Chen for this thorough analysis. drive.google.com/file/d/12oIqq5…

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Oxford Science Enterprises @OxfordSciEnt

3 years ago

Delighted to announce that our portfolio company @Miro_Bio is to be acquired by @GileadSciences for approximately $405 million. Read our full press release to learn more ⬇ bit.ly/3zzzJ2i

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Ohad Hammer @ohadhammer

3 years ago

RNA therapeutics landscape (private and public). From Cowen's recent RNA review.

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Sek Kathiresan MD @skathire

3 years ago

How did idea for @VerveTx come about? 👇 (L) April 2016, our response to @American_Heart One Brave Idea grant competition looking for coronary heart disease cure (R) Our proposed timeline from then, dose first patient in ~5y And (despite not getting award), right on time 😊

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Andreas Puschnik @andreaspuschnik

3 years ago

Preprint alert 🚨: #AAV vectors are one of the leading platforms for gene delivery for the treatment of human genetic diseases. Despite some clinical successes, AAV-based gene therapy still faces several challenges. biorxiv.org/content/10.110…

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Rosenblatt Lab @RosenblattLab

3 years ago

The cost of living crisis in the UK has severely impacted post-graduate researchers. This is an open letter to the UKRI petitioning for the support of an increase to their stipend. Please support and share! docs.google.com/document/d/17n…

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Eric Topol @EricTopol

3 years ago

Genome editing for potential definitive treatment or curies for many genetic conditions is moving forward at high velocity. A new @CellCellPress review is a masterful state-of-the-science for delivery cell.com/cell/fulltext/… @davidrliu @samagyabanskota @liugroup @broadinstitute

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Junhong Choi @_Choi_Junhong

3 years ago

The peer-reviewed version of DNA Ticker Tape (now “DNA Typewriter”) is out today! During revision, we have expanded our lineage recording demonstration by integrating DNA Tape recording with single-cell RNA-seq (1/8) nature.com/articles/s4158…

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Gene Yeo’s Lab at UC San Diego @yeo_lab

3 years ago

Myotonic dystrophy type 1 (DM1) is the most common form of muscular dystrophy but the molecular basis for neurocognitive defects in DM1 patients is unknown. Excited to share our cover work where we generated 3D cortical organoids from DM1 patients. science.org/doi/10.1126/sc…

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Muhammad Hanifi @_muhammadhanifi

3 years ago

It's been a huge privilege to do my DPhil alongside fantastic labmates, collaborators, and mentors at @MRC_WIMM and @OxPaediatrics. Pushing the last mile for the paper and can't wait to bring this tech from bench to bedside. @TSS_Lab @rinaldi_ca @RDMOxford

Tatjana Sauka-Spengler @saukaspengler

3 years ago

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Eric Topol @EricTopol

3 years ago

'A complete remission in every single patient is “unheard-of”' Combining genomics diagnosis of mismatch repair deficient + PD-1 immunotherapy led to complete remission of 18 consecutive patients w/ advanced colorectal cancer nejm.org/doi/full/10.10… nytimes.com/2022/06/05/hea… #ASCO22