Yu-Fei Ao 敖宇飞 @aoyufe
Biocatalysis and organic synthesis; Associate Professor; Institute of Chemistry, Chinese Academy of Sciences Joined April 2013-
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Just published our Perspective review in Chem Catalysis: “Machine learning-assisted protein engineering for improving stereoselectivity.” 🚀🤖🧬 #ChemCatalysis #MachineLearning #ProteinEngineering #Catalysis sciencedirect.com/science/articl…
👉Have you read the #research article Machine learning-guided protein engineering to improve the catalytic activity of transaminases under neutral pH conditions by @aoyufe's team? #biocatalysis #enzyme #machinelearning 🔗doi.org/10.1039/D5QO00…
Research Highlight now online: Predicting enantioselectivity for diverse substrates by @ali_stoddart nature.com/articles/s4416… ($) Highlighting the @NatureComms article by Lin Shen, Xuebo Chen, Yu-Fei Ao and co-workers
Machine learning-assisted amidase-catalytic enantioselectivity prediction and rational design of variants for improving enantioselectivity @UCAS1978 @NatureComms nature.com/articles/s4146… Biocatalysis is an attractive approach for the synthesis of chiral pharmaceuticals and fine…
An Artificial Single Molecular Channel Showing High Chloride Transport Selectivity and pH-Responsive Conductance (Dexian Wang and co-workers) @Annie931118 @UCAS1978 onlinelibrary.wiley.com/doi/10.1002/an…
Our new molecular hourglass, beautiful and effective.
Structure- and Data-Driven Protein Engineering of Transaminases for Improving Activity and Stereoselectivity (Uwe T. Bornscheuer and co-workers) @aoyufe @uni_greifswald #openaccess thanks to #projektDEAL onlinelibrary.wiley.com/doi/10.1002/an…
"Dimensions – Naphthalene-Pillared Benzene Triimide Cage: An Efficient Receptor for Polyhedral Anions and a General Tool for Probing Theoretically-Existing Anion-π Binding Motifs" has published in CCS Chemistry. Congratulation to De-Hui Tuo! chinesechemsoc.org/doi/10.31635/c…
Wooow, the third paper from Na Luo in 2021, Congratulations! a Putting anion‐π interactions at work for catalysis …mistry-europe.onlinelibrary.wiley.com/doi/10.1002/ch…
Thanks and congratulations to Peng-Wei and Prof. Zhou! Wonderful work! Enantioselective Synthesis of Cα-Tetrasubstituted N-Hydroxyl-α-amino Nitriles via Cyanation of Ketonitrones Using Me2(CH2Cl)SiCN pubs.acs.org/doi/10.1021/ac…
Cation-chloride cotransport mediated by an ion pair transporter - now published in Organic & Biomolecular Chemistry. Congratulation to Jun Zhu and Xu-Dong Wang! pubs.rsc.org/en/content/art…
pi-Face Promoted Catalysis in Water: From Electron-deficient Molecular Cages to Single Aromatic Slides (Wang) onlinelibrary.wiley.com/doi/10.1002/as…
Modification of the Enantioselectivity of Biocatalytic meso-Desymmetrization for Synthesis of Both Enantiomers of cis-1,2-Disubstituted Cyclohexane by Amidase Engineering (Ao) onlinelibrary.wiley.com/doi/10.1002/ad…
I am very pleased to share our recently results in @AdvSynthCatal, on the amidase engineering for its enantioselectivity modification. Congratulation to Dr. Hui-Juan Hu! onlinelibrary.wiley.com/share/author/T…
This new journal, Green Synthesis & Catalysis, is dedicated to publishing high-impact research discoveries and results from academic and industrial laboratories on sustainable synthetic technologies for molecule construction and production. Excellent! sciencedirect.com/journal/green-…
This new journal, Green Synthesis & Catalysis, is dedicated to publishing high-impact research discoveries and results from academic and industrial laboratories on sustainable synthetic technologies for molecule construction and production. Excellent! sciencedirect.com/journal/green-…
We are very pleased to learn that the open access version of our article "Enantioselective biocatalytic desymmetrization for synthesis of enantiopure cis-3,4-disubstituted pyrrolidines" is now available online. doi.org/10.1016/j.gres…
Exploiting Anion-pi Interactions for Efficient and Selective Catalysis with Chiral Molecular Cages (Wang) onlinelibrary.wiley.com/doi/10.1002/an…
Rational strategy is powerful for reducing the efforts and cost on protein engineering. Our recent paper in @ACSCatalysis reported the reversal of protein's steroselectivity by screening less than 10 mutants. Just like a sniper, one bullet, one target. pubs.acs.org/doi/full/10.10…

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OrgChemFront @OrgChemFront
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Chem Catalysis @ChemCatalysis
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CCS Chemistry @CCSChemistry
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Nature Synthesis @NatureSynthesis
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