Brian Krug @bKrugSci
Postdoc at Columbia University:https://t.co/9e8cHTyADi PhD McGill U:https://t.co/wcZkFYX8XE Cancer & chromatin biology New York Joined April 2021-
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Excited to share our new preprint on the interaction between DNMT3A1 and H2AK119Ub. This work is the fruit of a collaboration between @LuLaboratory, @KJArmache Lab and @epicypher and co led with @Xagbomson biorxiv.org/content/10.110…
Sparse CBX2 nucleates many Polycomb proteins to promote facultative heterochromatinization of Polycomb target genes dlvr.it/T2MGmV
Beyond favoring cPRC1 condensate polycomb bodies, H3.3K27M mutations alter another nuclear compartment; promyelocytic leukemia (PML) bodies, with implications for impaired glioma differentiation in work by the group of Lee Wong: genomebiology.biomedcentral.com/articles/10.11…
It took a while but here it is! Excited to share our latest work led by Xiao Chen and Yinglu Li on the interplay between PRC2 and MLL-MEN1 complex in lymphoid cancers identified through genetic co-dependency mapping. nature.com/articles/s4146…
Here we go: a study led by Yinglu Li, Lizzy Goldberg and Xiao Chen in the lab explores why NSD1 tumors are both DNA hypomethylated and immune cold, and how to target them. authors.elsevier.com/a/1ftBC3vVUPK9…
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364 Followers 628 Following BIG science fan Post-doc: @maxvcg PhD: @LorinczMatthewNucleation and spreading maintain Polycomb domains every cell cycle dlvr.it/T5XDJc
Incredibly proud of my wife @Irene_xzwen's PhD thesis work featured in @Nature! They unveil a breakthru technology that jointly profiles RNA-RNA, DNA-DNA, and RNA-DNA proximity in single cells. The physical layout of these 2 constituents "changes shape" in neurons as we age!
Thrilled to announce our paper in @Nature introducing MUSIC! For the first time, MUSIC enables simultaneous mapping of multiplexed chromatin interactions, RNA-chromatin interactions, RNA-RNA interactions & gene transcription at single-cell resolution. doi.org/10.1038/s41586…
Very excited to see our work on PRC1 and chromatin condensation online @MolecularCell cell.com/molecular-cell… I am grateful to have worked with and learned from Sharon and @theresaoei during this project! Many thanks to Radhika and Bob for their guidance and support throughout!
Please see our collaborative paper with @LuLaboratory and @GCloner @epicypher led by @KristjanGretars and @Xagbomson. Congrats, and a big thank you to everyone involved!
Excited to share our new preprint on the interaction between DNMT3A1 and H2AK119Ub. This work is the fruit of a collaboration between @LuLaboratory, @KJArmache Lab and @epicypher and co led with @Xagbomson biorxiv.org/content/10.110…
Please see tweetorial below for the latest from the lab led by @KristjanGretars. In collaboration with @GCloner @KJArmache @Xagbomson, this work reveals molecular details of DNMT3A targeting to polycomb CGIs and its implication for cancer-associated DNA hypermethylation.
Excited to share our new preprint on the interaction between DNMT3A1 and H2AK119Ub. This work is the fruit of a collaboration between @LuLaboratory, @KJArmache Lab and @epicypher and co led with @Xagbomson biorxiv.org/content/10.110…
Cancer-associated DNA Hypermethylation of Polycomb Targets Requires DNMT3A Dual Recognition of Histone H2AK119 Ubiquitination and the Nucleosome Acidic Patch dlvr.it/T4McsQ
Excited to share our new preprint on the interaction between DNMT3A1 and H2AK119Ub. This work is the fruit of a collaboration between @LuLaboratory, @KJArmache Lab and @epicypher and co led with @Xagbomson biorxiv.org/content/10.110…
Day 1️⃣ of the Tsai Lab @ChildrensLA today! So grateful to be here and stoked to get the science started! 🧫🧬🧠
@JustinLathia @NeuroOnc @AnthonyrSloan @DJ_Silver_PhD We felt the need to talk about CSCs in terms of new concepts, including cell plasticity, and more traditional ones, like the essentiality of robust functional assays. Hope y’all enjoy this read.
I feel like it has been a while since we talked about #CancerStemCells - excited to present a new review with @MarcoGalloLab just out in @NeuroOnc on #GBM CSCs led by @AnthonyrSloan @DJ_Silver_PhD #BTSM academic.oup.com/neuro-oncology…
So excited to finally see this out in its final form!!! nature.com/articles/s4158…
I am truly thrilled to announce that I will start as a tenure track Assistant Professor at Children's Hospital Los Angeles in the Cancer and Blood Disease Institute and Keck School of Medicine in March 2024! 🧠1/
Congratulations to @jestsai who we are all very proud of. Excited to see the discoveries that she and Tsai lab will make for our children with brain tumors.
I am truly thrilled to announce that I will start as a tenure track Assistant Professor at Children's Hospital Los Angeles in the Cancer and Blood Disease Institute and Keck School of Medicine in March 2024! 🧠1/
The paper version of our DNMT3B study is now out in @emboreports 🥳: embopress.org/doi/full/10.10… You can read more on the previous thread but here is a summary of the main updates. This is one for Southern blot fans! 🧵1/9
New pre-print alert 🚨 @franci_tag shows that DNMT3B PWWP mutations cause hypermethylation of H3K9me3 heterochromatin that is facilitated by its N-terminus. You can read more here: biorxiv.org/content/10.110… But here is a quick summary 🧵 1/10
Sparse CBX2 nucleates many Polycomb proteins to promote facultative heterochromatinization of Polycomb target genes dlvr.it/T2MGmV
Metabolic regulation of the hallmarks of stem cell biology dlvr.it/T2BVsm
First day as a postdoc in the @PauliGroup @IMPvienna ! Excited to dive into dormancy research in a new context! 🐟 🐟 Looking forward to the next years in the world’s most livable city 🏔️🎶😎
Excited to share our recent study in @CellCellPress led by @GiuseppeLeuzzi_ on the dual role of the DNA translocase SMARCAL1 in regulating innate immune signaling and the expression of the PD-L1 immune checkpoint factor! authors.elsevier.com/a/1iWe5L7PXqPXc
In 2017, I moved to San Diego to start an MD-PhD, an 8-year program. "8-years!" people would gasp, "Is that program even legal?" To show the passage of time, I got a house plant, thinking I’d take a photo at the start and finish, hoping the succulents would thrive as living…
Check out our last paper focusing on altered DNA repair in H3.3 mutant pediatric high-grade glioma! We identified a specific molecular vulnerability with potential for therapeutic targeting. Thank you to our collaborators. pubmed.ncbi.nlm.nih.gov/38214234/