Dow Lab @dow_lab
Cancer genetics & biology lab, building and applying new genetic technologies in search of better treatment options for cancer patients dowlab.org Manhattan, NY Joined March 2018-
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Dow Lab retweeted
Preprint from @dow_lab @WeillCornell using CRISPR base editing screens: Genetic mechanisms of resistance to targeted KRAS inhibition biorxiv.org/content/10.110… MAPK reactivation remains the predominant mechanism of resistance to KRASinh. Also identifies a hotspot mutation in CiC.
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Dow Lab retweeted
Excited to share the preprint of my postdoc work @dow_lab and @MSKCancerCenter! Joint work with co–first author @kevanchu Link: doi.org/10.1101/2025.0…
Haven't been on here since the first Tuesday in Nov, but... ...today I was promoted to Professor with tenure at @WeillCornell and wanted to post one last time to thank everyone that has helped our lab over the past 10 years! Science and guitar posts continue @dowlab.bsky.social
Alright, America… Let’s see if we can (finally) elect a more than qualified female candidate over an abundantly unqualified male. I’m looking at you, PA & WI. Vote!!
Ok, so unpopular opinion, I guess… I don’t think news entities should ever endorse political candidates. They can and SHOULD report objectively on all the terrifying stuff coming from DJT. I’d much rather honest reporting than ‘both-sidesing’ and editorial opinions. Inform us!
Dow Lab retweeted
6 years of work + Over 2 years in review + 1 extremely talented graduate student @LeonaNease + Amazing collaborators = One extremely cool new mechanism that regulates metastasis through modification of the selenocysteine tRNA! nature.com/articles/s4301…
In no other field do you hire someone for their immense expertise in a very niche field and immediately ask them to change what they do… science is weird.
In no other field do you hire someone for their immense expertise in a very niche field and immediately ask them to change what they do… science is weird.
Dow Lab retweeted
Distinct clinical outcomes & biological features of specific KRAS mutants in human pancreatic cancer @Cancer_Cell doi.org/10.1016/j.ccel… 👉KRASG12R enriched in early stage w/ reduced nodal disease + distant recurrence 👉improved OS 🧐 Supports KRAS mutational testing in #PDAC…
Dow Lab retweeted
@dow_lab we're looking forward to your presentation at #AMC25 in the Dominican Republic🇩🇴 next February! Please RT to let your followers know Talk Submission closes next week! ✅Register & Submit: bit.ly/3BbtGoY
10 years old today... the lab is double digits!! Happy birthday to us!
Dow Lab retweeted
Online Now: Distinct clinical outcomes and biological features of specific KRAS mutants in human pancreatic cancer dlvr.it/TCXth0
I see many delicious cocktails in my future… #oldfashionedtime
Sure have enjoyed the last two weeks of hope-scrolling more than the past years of doom-scrolling! Can we keep this train on the tracks, please!! 🙏🏻
Dominican Republic in the “F-off” stage of winter, cool mouse models, some state-of-the-art gene editing… what more could you want?! Come hang on the beach!
Dominican Republic in the “F-off” stage of winter, cool mouse models, some state-of-the-art gene editing… what more could you want?! Come hang on the beach!
Dow Lab retweeted
📆Save the Date📆 Chairs @KevinHaigisLab & @SageJulien are back to bring us the second instalment of our Animal Models of Cancer conference. #AMC25 will take place from 26 Feb - 01 March 2025 in the Dominican Republic!✅Registration now open: bit.ly/3zK9wBP
8 months later, but now get to celebrate a safer (single digit) score on the A1! 🍾
8 months later, but now get to celebrate a safer (single digit) score on the A1! 🍾
This seems obvious now, but… For those using #mageck for heavily bottlenecked (positive selection) screens -> do your own read normalization, then turn off normalization when you run the package. Median normalization was wreaking havoc on our data
This seems obvious now, but… For those using #mageck for heavily bottlenecked (positive selection) screens -> do your own read normalization, then turn off normalization when you run the package. Median normalization was wreaking havoc on our data
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