Tanmoy Sanyal @hiddenvariable2
Protein design @Amgen. Previously, @novonordisk, @salilab_ucsf, @UCSBCHE, @IITKgp. tanmoy7989.github.io San Francisco Bay Area, CA Joined June 2016-
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Retraining PLMs with newly deposited sequences doesn't guarantee better performance. Authors trained PLMs on each copy of UniRef100 from 2011 to 2024; the largest performance boost (2021->2022) coincided with the removal of unusually large number of invalid sequences from UniRef
Retraining PLMs with newly deposited sequences doesn't guarantee better performance. Authors trained PLMs on each copy of UniRef100 from 2011 to 2024; the largest performance boost (2021->2022) coincided with the removal of unusually large number of invalid sequences from UniRef https://t.co/eEb6u0uX66
Let me tell you a story. It'll end up at the current tech-bio and protein design scene. But the story starts about 25 years earlier. Did you know that, commercially, the human genome project precipitated the end and not the start of a genomics boom? 1/
1/5 Today, I’m sharing 7yrs of work. I believe we discovered a comprehensive mapping from protein structure to glycan structure, a genetic encoding for specific glycans, and a new paradigm in extracellular biology. biorxiv.org/content/10.110… #Glycotime
Editors rant: how many more GNN or message-passing architectures do we *really* need to score/predict protein-ligand interactions? A new one appears every day!!! 🤯#compchem
Working on ML for Drug Discovery I have been frustrated with the size and/or quality of publicly available datasets to train and benchmark models with, so when my co-founder and I started our company we swore we would open-source some data as quickly as possible.
arxiv.org/abs/2401.17894 We wrote a review on recent developments in integrative modeling and frontiers in the field for a Springer Mol Bio Handbook. Comments are appreciated! Deep work by co-first authors @s_arvindekar @KartikMajila
The sad reality is that most people don't have what it takes to work in tech: Up at 4am. Post a pic of my new Eight Sleep in the group chat for sweet, sweet engagement. Hit the gym. Crush 8 jumping jacks. 35 minute cold plunge. Rip a My First Million episode at 2x speed.…
𝐈𝐧𝐝𝐢𝐚𝐧 𝐑𝐞𝐬𝐞𝐚𝐫𝐜𝐡 𝐂𝐫𝐢𝐬𝐢𝐬 - 𝐍𝐨𝐭 𝐣𝐮𝐬𝐭 𝐚 𝐒𝐦𝐨𝐤𝐢𝐧𝐠 𝐆𝐮𝐧 𝐛𝐮𝐭 𝐚 𝐃𝐮𝐦𝐩𝐬𝐭𝐞𝐫 𝐅𝐢𝐫𝐞 If you had any doubts about Indian Research being in a deep crisis, this graph should definitively lay them to rest. (1/N) 🧵 #IndiaResearchCrisis
Chandrayaan-3 Mission: 'India🇮🇳, I reached my destination and you too!' : Chandrayaan-3 Chandrayaan-3 has successfully soft-landed on the moon 🌖!. Congratulations, India🇮🇳! #Chandrayaan_3 #Ch3
In 2008 October, I was back from college for a weekend visit to my parents, when the Chandrayaan-1 mission happened. 15 years later life comes full circle: my parents are visiting me on their vacation when Chandrayaan-3 soft-lands an unmanned rover on the moon!
Excited to have nearly the entire integrative structural modeling community in one place: tremendous effort by @shruthiLab! Also, I am teaching a brief workshop on writing Python-based custom restraints within the Integrative Modeling Platform (IMP), please attend if interested.
Excited to have nearly the entire integrative structural modeling community in one place: tremendous effort by @shruthiLab! Also, I am teaching a brief workshop on writing Python-based custom restraints within the Integrative Modeling Platform (IMP), please attend if interested.
I wonder what does it feel like to be a normie and work in a field where you don’t have to upskill every couple of hours.
Register by this week for conference on Macromolecular assemblies @IISERPune and workshop on integrative modeling with @salilab_ucsf bit.ly/462MmlN
1/8 Excited to introduce CombFold - an algorithm for predicting large multi-protein complexes using the combinatorial and hierarchical assembly of #AlphaFold models. @DinaSchneidman biorxiv.org/content/10.110…
Some perspective for scientists who may be asked to review computational methods: Computational methods are indeed innovated by taking existing mathematical and algorithmic atoms and putting them together in a novel way. Second, small changes in the steps can have a large…
Really excited to present new work by @ritagonmar: we visualized the entire PubMed library, 21 million biomedical and life science papers, and learned a lot about -- THE LANDSCAPE OF BIOMEDICAL RESEARCH biorxiv.org/content/10.110… Joint work with @CellTypist and @benmschmidt. 1/n
We wrapped up the first LLM hackathon for applications in materials and chemistry last week. The results to me were astounding. We are at the point now where some tasks that took years can now be completed in days. Here is a list of the fantastic submissions!
I'm serious. STEM without the Arts, Social Sciences, and Humanities will produce more "innovative" tech bros who giddily reinvent rent, roommates, taxes, and now...roller skates. With complete, straight-faced, sincerity. This is a problem. And I have a list (So, thread 🧵)
I'm serious. STEM without the Arts, Social Sciences, and Humanities will produce more "innovative" tech bros who giddily reinvent rent, roommates, taxes, and now...roller skates. With complete, straight-faced, sincerity. This is a problem. And I have a list (So, thread 🧵)
It’s time to peel back the curtains of the struggles of a #NewPI trying to find her way. I was invited to interview for an award that was a great match for my research. Here is me cheesing before the interview… Little did I know how quickly would change... [long] 🧵

Andrew White 🐦�... @andrewwhite01
27K Followers 2K Following Head of Sci/cofounder @FutureHouseSF. Prof of chem eng @UofR (on sabbatical). Automating science with AI and robots in biology. Corvid enthusiast
Sergey Ovchinnikov @sokrypton
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Jim Pfaendtner @JimPfaendtner
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Neelanjana Sengupta @NeelanjanaSeng1
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Sam Power @sp_monte_carlo
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Avner Schlessinger @SchlessingerLab
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Paul Robustelli @PaulRobustelli
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John Chodera (he/him) @jchodera
9K Followers 7K Following Changing drug discovery one ratio of partition functions at a time. Heading up antiviral discovery for pandemics: https://t.co/uN4XpX1mjt https://t.co/YAg9PBYuBl
Suman Chakrabarty @SumanPhysChem
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Greg Bowman @drGregBowman
9K Followers 1K Following Imperfect Christ-follower desperately searching for truth, especially through science. Prof @Penn. Director @foldingathome. Legally blind. Father
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debarghya mitra @debarghyamitr19
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LAMMPS tutorials @lammpstutorials
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Grey @peeseauc58665
23 Followers 2K Following Be brave enough to choose the life you want to live and stick to it. This is a great life.
Greg Dignon @Dignon_Lab
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PhDs of India @PhDsofIndia
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John Karanicolas (he/... @JohnKaranicolas
733 Followers 519 Following Advancing scientific knowledge to benefit human health. Head of computational drug discovery at AbbVie.
Dr Neha S Gandhi 🇮... @dr_nehagandhi
652 Followers 1K Following Researcher, team leader chasing biomolecules using computational techniques 👩💻
Vega Shah @dr_alphalyrae
19K Followers 4K Following AI for Life Sciences & Healthcare @NVIDIA | trained as a scientist from @JGI, @UW, @UCBerkeley | building global community @TechBi0 | views are all mine
Maxim Ziatdinov @MaximZiatdinov
2K Followers 2K Following I use artificial intelligence to boldly go where no human has gone before in experimental sciences. Opinions are my own, but please don’t hold them against me.
Sebastian @SassSeabass
696 Followers 692 Following computational peptide design at @novonordisk | PhD in the @Keating_Lab at @mit | undergrad at @umncbs | bsky @ bassafras. views are my own
Parichitran A @parichitran
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Cory Simon @CoryMSimon
3K Followers 2K Following ChemE prof @ Oregon State University | Bayesian optimization, inverse problems, algos for mobile robots | dog-walking, bike-riding, Starcraft, wine | views mine
P212121 @moleculesrus
157 Followers 403 Following
Rohit Satija @rohitium
191 Followers 1K Following Scientist, Engineer, Entrepreneur; prev Genentech, UC Berkeley, UT Austin, IIT Delhi; views my own
Guoqiang Yi @GuoqiangYi
85 Followers 3K Following
André Cavalcante @AndreNabla
222 Followers 879 Following Professor @ Dept. of Electrical Engineering, Universidade Federal do Maranhão, Brasil. Working on ML.
Kushal K Dey @kanishkadey
811 Followers 520 Following Assistant Member/Professor, Computational and Systems Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center
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14K Followers 3K Following Neuroscientist, Psychiatrist, Physicist. he/him @drbreaky.bsky.social
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93 Followers 236 Following
Mouktik Raha @MouktikR
34 Followers 128 Following Quantum Research Scientist @AWS Center for #Quantum Networking | Previously, postdoc @UChicago, PhD @Princeton | @IITKgp alum
Balogun Toheeb @Balogun__Toheeb
101 Followers 577 Following Bioinformatics || Computational Biology || Molecular Pharmacology and Therapeutics
Catherine A. Moulder @CMoulder4
129 Followers 764 Following I'm back. Aspiring academic looking to teach the joy of chemistry to the interested and make it interesting to the disinterested. I like to share the good.
Sourav Pal @SouravP32813910
6K Followers 4K Following Professor Ashoka University Former Director IISER Kolkata Former Director CSIR NCL Pune Former Professor IIT Bombay
Davide Michieletto @Dmichiel1
2K Followers 2K Following @RoyalSociety University Research Fellow @EdinburghUni @PhysAstroEd. @ERC_Research StG on Topologically Active #DNA Materials. Always learning 🧬
Abhirup Patra, Ph.D. @TrickyPlasmon
404 Followers 1K Following Materials Science Researcher @Shell Ph.D. in Physics @TempleUniv Previously @tulane @Penn | AI for materials and molecules
Kira Mills @ki_rmills
240 Followers 285 Following she/they | Science Marketing | UTD '23 PhD in #compchem | TAMUC '18 McNair scholar | #QueerInSTEM
Razeen🪰 @RazeenShake
393 Followers 1K Following Quantitative Developmental Biology | ChemE Ph.D. student @TAMU @reeveslab | Alum @ICTMumbai1933 | 🏳️🌈
@semihakbali.bsky.soc... @semihakbali
384 Followers 1K Following
Andrew White 🐦�... @andrewwhite01
27K Followers 2K Following Head of Sci/cofounder @FutureHouseSF. Prof of chem eng @UofR (on sabbatical). Automating science with AI and robots in biology. Corvid enthusiast
Kresten Lindorff-Lars... @LindorffLarsen
15K Followers 2K Following Protein and coffee lover, father of two, professor of biophysics and sudo scientist at the #LinderstrømLang Centre for Protein Science 🇩🇰
Kevin K. Yang 楊凱�... @KevinKaichuang
21K Followers 6K Following Principal Researcher in BioML @MSFTResearch (@MSRNE). He/him/他. 🇹🇼
Sergey Ovchinnikov @sokrypton
16K Followers 4K Following Scientist, Assistant Professor @MITBiology, #FirstGen, ProteinBERTologist, 🇺🇦 No Human is illegal. Moving to: https://t.co/sow6IRD3jj
Samrat Mukhopadhyay @SamratLabMohali
21K Followers 2K Following Professor @IISERMohali Editor @BiophysJ Studying biological condensates associated with cell physiology and disease Attended @IIScBangalore @ScrippsResearch
Anand Srivastava @mbuanand
3K Followers 513 Following Anand Srivastava, Associate Professor, Molecular Biophysics Unit, Indian Institute of Science (IISc)-Bangalore
Oded Rechavi @OdedRechavi
144K Followers 1K Following Epigenetic Inheritance, Neuroscience & anything biology-related TED: https://t.co/rcOm9TSTf5 Huberman Lab Podcast: https://t.co/xZTNlx9nbi
Jim Pfaendtner @JimPfaendtner
7K Followers 3K Following Dean of Engineering, Faculty, Mental health advocate, @JPhysChem senior editor, PS5 enthusiast, fantasy/sci-fi.
Lior Pachter @lpachter
47K Followers 2K Following Bren Professor of Computational Biology @caltech. Blog at https://t.co/FFQzhEsmhi. Tweets represent my views, not my employer's. #methodsmatter
Arindam Ghosh @ArindamPhysics
35K Followers 928 Following Physicist, researcher and teacher...at Indian Institute of Science. Views are my own. RTs are not necessarily endorsement.
Markus Deserno @MarkusDeserno
9K Followers 222 Following Theoretical and computational biophysicist @CarnegieMellon. Loves lipid membranes. (he/him) 🇩🇪🇺🇸
Neelanjana Sengupta @NeelanjanaSeng1
2K Followers 856 Following Biophysicist (the paper-pen-in silico type); Teacher; Mom
Frank Noe @FrankNoeBerlin
12K Followers 548 Following Scientist, #MachineLearning and #AI for the Sciences (esp. Physics/Chemistry). Scuba Diver and Traveler.
Avner Schlessinger @SchlessingerLab
3K Followers 3K Following Computational biologist. Professor. Co-Director of Disease Mechanisms and Therapeutics Training Area @IcahnMountSinai. Opinions are mine. #DrugDesign #AI
eLife - the journal @eLife
172K Followers 709 Following The funder-researcher collaboration and open-access journal for research in the life and biomedical sciences | @eLifeCommunity
Olexandr Isayev 🇺�... @olexandr
10K Followers 4K Following #CompChem Prof @CMU_Chem. Connecting chemical sciences with AI & #MachineLearning. #tarheels fan. Care:#design, #photography #Ukraine #cats🐈 Rants are mine
Paul Robustelli @PaulRobustelli
3K Followers 1K Following Assistant Professor at Dartmouth College Computational Biophysics / Disordered Proteins / Molecular Recognition
Ariane Nunes Alves @anunesalves
5K Followers 3K Following Computational Biochemist | Junior Group Leader @UniSysCat @TUBerlin | Associate Editor @jcim_jctc | 🇧🇷 #CompChem (ligand binding kinetics, crowding)
Sebastian Raschka @rasbt
358K Followers 1K Following ML/AI researcher & former stats professor turned LLM research engineer. Author of "Build a Large Language Model From Scratch" (https://t.co/O8LAAMRzzW).
Jen Heemstra @jenheemstra
93K Followers 13K Following Professor and Chair of @WashUChem, proud member of @HeemstraLab. I'm a researcher, but I'm a #MentorFirst. Author of Labwork to Leadership.
Sriram Krishnan @sriramk
303K Followers 1K Following White House Senior Policy Advisor for AI. pro wrestling fan. official: @skrishnan47
U.S. Consulate Kolkat... @USAndKolkata
66K Followers 791 Following Official Twitter account of the U.S. Consulate Kolkata. Terms of use: https://t.co/dlGCmbBhRO
Jeff Bezos @JeffBezos
6.9M Followers 485 Following Amazon. Blue Origin. Washington Post. Bezos Earth Fund. Bezos Academy.
Satya Bikash @SatyaBikash1
22 Followers 524 Following
debarghya mitra @debarghyamitr19
83 Followers 349 Following Research Scholar @iitbombay @ANmrlab Scaling Protein Motions through NMR and MD
Yogi Adityanath Offic... @myogioffice
11.5M Followers 13 Following Twitter account of https://t.co/wyDBIIaREe – Shri Yogi Adityanath Ji personal website & office
Yogi Adityanath @myogiadityanath
32.5M Followers 59 Following मुख्यमंत्री (उत्तर प्रदेश); गोरक्षपीठाधीश्वर, श्री गोरक्षपीठ; सदस्य, विधान सभा, उत्तर प्रदेश; पूर्व सांसद (लोकसभा-लगातार 5 बार) गोरखपुर, उत्तर प्रदेश
Rahul Gandhi @RahulGandhi
28.3M Followers 372 Following Leader of Opposition, Lok Sabha | Member of the Indian National Congress | Member of Parliament, Raebareli
Amit Shah @AmitShah
37.1M Followers 316 Following Union Home Minister, Minister of Cooperation and MP, Gandhinagar Lok Sabha. https://t.co/jEf4rOW2AD
Tulsi Gabbard 🌺 @TulsiGabbard
3.8M Followers 1K Following Director of National Intelligence. Former Presidential candidate & Congresswoman. Soldier. NYT bestselling author. (Views do not reflect position of USG/DoD)
Vivek Ramaswamy @VivekGRamaswamy
3.6M Followers 299 Following Father. Husband. Entrepreneur. Candidate for Governor of Ohio.
Stephen Miller @StephenM
1.6M Followers 355 Following @WhiteHouse Deputy Chief of Staff for Policy and Homeland Security Advisor | 45 & 47
Fremont Police Depart... @FremontPD
53K Followers 1K Following Fremont (CA) PD. Call 510-790-6800 x3 for services/report crime/tips. Emergency call 911. We do not monitor social 24/7 #SMpolicy https://t.co/vFrxB1BtTm
Sarath Chandar @apsarathchandar
6K Followers 608 Following Associate Professor @polymtl and @Mila_Quebec; Canada CIFAR AI Chair; Machine Learning Researcher. Pro-bono office hours: https://t.co/tK69DKRf9N?amp=1
NIMI VASHI (bio/acc t... @nimivashi15
4K Followers 6K Following Co-Founder & CEO @ Stealth Biotech. Scientist. Alum: @mskcancercenter @icgeb,Shipit @fdotinc. Mentor @IGEM, @tks. Cancer expert @bbcworld. Bio/Acc.
Chandrachur Ghose @chandrachurg
23K Followers 1K Following Author of '1947-57, India: The Birth of a Republic', 'Bose: The Untold Story of an Inconvenient Nationalist', ‘Conundrum: Subhas Bose’s Life After Death’.
Dibyendu Nandi @ydnad0
9K Followers 4K Following physicist & night blind astronomer; creator https://t.co/oo7SocydeN; space weather; sehnsucht; what is essential is invisible to the eye ☀️🌏🌒🌠B^2
Raj Dabre @prajdabre
16K Followers 1K Following Senior Research Scientist - @google, Adjunct Faculty - @iitmadras, @iitbombay, Ex: @NICT_Publicity Use of my tweets without permission ➡️ legal action
Pranam Chatterjee @pranamanam
4K Followers 339 Following Generating biologics to program biology! 💻🧫 Assistant Professor at @Penn | Co-Founder @GametoGen and @UbiquiTxINC | Formerly @MIT '16 '18 '20 and @harvardmed
Tanmoy Roychowdhury �... @TanmoyRoychow13
238 Followers 434 Following Genomics & Precision Health @TSB_Ashoka, @KCDH_A . Previously - @YaleGenetics, @umichmedicine, @MayoClinicCIM, @JNU_official_50
Open Letter @openletteryt
85K Followers 524 Following video creator | social commentary | 1M+ community 🇮🇳
Rohit Singh @rohitsingh8080
2K Followers 626 Following Computational biologist. Faculty @DukeU. Co-founder https://t.co/NPPgsZa9sa. Prev @MIT_CSAIL. Did quant investing for a while, before returning to research.
Nathan C. Frey @nc_frey
4K Followers 1K Following CTO & Co-Founder, Coefficient Bio | Ex-@PrescientDesign • @Genentech | Advisor @atomscale & @guidelabsai | @MIT, @Penn PhD, @BerkeleyLab
AI4Bharat @ai4bharat
9K Followers 128 Following The focus of AI4Bhārat, an initiative of IIT-Madras, is on building open-source language AI for Indian languages, including datasets, models, and applications.
Kevin M Jablonka @kmjablonka
2K Followers 3K Following Trying to teach computers about materials @jablonkagroup @UniJena & @HZBde. You can use https://t.co/HXvlhpq56i to provide feedback.
Anuj Dhar @anujdhar
104K Followers 2K Following Fighting for the truth about Netaji Subhas Chandra Bose for 2 decades. For those who want to support me, my UPI ID is: anuj.dhar@axl
Janani Durairaj (Jay) @janani_hex
539 Followers 178 Following Computational biologist. Likes protein structures. @biozentrum with @TorstenSchwede. Now mainly on Bluesky: https://t.co/2DNCLAwSxU
Krish Ashok @krishashok
94K Followers 713 Following Techie (https://t.co/dULL1kpela), Author of Masala Lab (https://t.co/MdeRPLmgVz…), Musician (https://t.co/9sVjqvRpa4)
Steven Brown @AttyStevenBrown
10K Followers 337 Following Houston-based immigration attorney focusing on business and investor immigration. Opinions are my own. Not legal advice.
Deep Origin @DeepOriginBio
255 Followers 130 Following It shouldn't take 10 years to deliver one drug. Time to un#uck life sciences and put the scientist first. Let's untangle the complexity of life.
Robert Webber @bobwebberlawyer
1K Followers 371 Following US immigration attorney (https://t.co/uH5jJVZe4X)
Patrick Hsu @pdhsu
47K Followers 3K Following @ArcInstitute co-founder, @BerkeleyBioE professor, @ThriveCapital investor | 🇨🇦 prev @harvard @broadinstitute, Fast Grants
Jay Bradner, M.D. @jaybradner
23K Followers 906 Following Physician-scientist making medicines with friends, memories with family. EVP R&D at Amgen
Stories of Aryavarta @Aryavarta_story
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Vicharak @Vicharak_In
9K Followers 5 Following We make computers that you can use to build robots, drones, intelligent machines, IoT solutions, or simply for fun and experimentation
Rohit Sharma 🇺🇸... @DcWalaDesi
31K Followers 1K Following
Anil Gupta @anil_am22
4K Followers 209 Following AI Apps for Immigration & Finance. AI Visa Photo: https://t.co/y0XR0q0p1M
Ravi Tandon @ravi_tandon
1K Followers 526 Following Building DecoverAI | Software Engineer | Princeton Grad | Author | Builder | Dreamer
Saurabh Netravalkar @Saurabh_Netra
18K Followers 52 Following Official X(Twitter) Account of Saurabh Netravalkar: Principal Member of Technical Staff at Oracle, Professional Cricketer at USA Cricket
Vinod Khosla @vkhosla
687K Followers 604 Following entrepreneurship zealot, grounded technology possibilist, believer in the power of ideas, passionate about sustainability & impact
Ratul Chowdhury @mrprotein24
244 Followers 114 Following Tailoring #proteins w/ and w/o #ML: #healthcare → #separations → #biocatalysis // ⇢ Assistant Professor ▨ Chemical & Biol. Engg ▨ Iowa State -views my own-
Saurabh @imsk_saurabh
22 Followers 32 Following