IntAct at EBI @intact_project
The Molecular Interactions Database at the EMBL-EBI. Open Source Framework for Molecular Interactions. Also follow➡️@complexportal. ebi.ac.uk/intact Cambridge, UK Joined May 2009-
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🧠 Today is #WorldAlzheimersDay. 📚 Visit the Complex Portal and learn more about gamma-secretase complexes, key to precise cleavage of amyloid precursor protein (APP), who's dysfunction is linked to disease progression (tinyurl.com/37exu532). #AlzheimersSociety
Continuing our Member Funder Focus series examining the contributions to biodata sustainability made by the organisations that comprise our Board of Funders. This week @AASciences - the African Academy of Sciences. Click here to read more bit.ly/4py7pqn #globalbiodata…
🧠World Alzheimer’s Day💜 IntAct highlights Tau-F 🧵 & amyloid beta 🧩 PPINs from human brain tissue. The Tau-F network shows mutations P301L/S 🧪 disrupting key pathways linked to Alzheimer’s. 🔗 Network: tinyurl.com/ynjwhy7y Paper: doi.org/10.3390/ijms24… #AlzheimersSociety
💜🧠 World Alzheimer’s Day 🧠💜 IntAct highlights Tau-F 🧵 & amyloid beta 🧩 PPINs from human brain tissue. The Tau-F network shows mutations P301L/S 🧪 disrupting key pathways linked to Alzheimer’s. 🔗 Network: rb.gy/nyuxgd 📚 Paper: doi.org/10.3390/ijms24…
IntAct release 251 is out! 1,726,205 binary interactions from 23,716 manually curated publications ebi.ac.uk/intact/about#s… (in sync with UniProt release 2025_03)
🧠 Alzheimer’s research meets precision medicine 📊 IMEx data from IntAct & Complex Portal 🧬 How AD mutations disrupt brain protein networks 🔍 Variant pathways, APP, miRNA 🚀 Toward targeted therapies 🔗 doi.org/10.1002/pmic.7… #KalpanaPannerselvam #IntAct #AlzheimersSociety
🧬 New in IntAct: Curated dataset from Pichlmair lab reveals VZV–host interactions in SK-N-BE2 cells. NPHP4 identified as a restriction factor; S862N variant alters interactome. Congrats V. Girault et al! 🔍 Explore: ebi.ac.uk/intact/search?… #IntAct #HostPathogen #@a_pichlmair
In our next release (2025_04) we will deploy a new Reference Proteome selection pipeline with the aim of improving the representation of species biodiversity in UniProtKB. Read our blog post to find out how this might affect your research: insideuniprot.blogspot.com/2025/06/captur…
🧠 Ever wonder how your tongue detects umami or sweetness? 🧂 Umami is sensed by a GPCR made of TAS1R1 + TAS1R3; sweet by TAS1R2 + TAS1R3. 🍜 Both trigger gustducin proteins, sending signals to your brain (and beyond). 🔬 Learn more: Complex Portal: tinyurl.com/ymd4ews9
Complex Portal release 251 is out! 5,190 manually curated biological complexes. ebi.ac.uk/complexportal/… (in sync with UniProt release 2025_03)
Excited to share the global proximity interactome in the Human Macroautophagy Pathway! (See: tinyurl.com/bdfaeztn) Study uncovers novel role of OSBPL family lipid transport proteins as new players in autophagy.See IntAct: tinyurl.com/34ksav36 #Macroautophagy #BrumellLab
Excited to share the global proximity interactome in the Human Macroautophagy Pathway!(PMID: 34524948). Study uncovers novel putative connections including the OSBPL family lipid transporters, new players in autophagy.See IntAct: tinyurl.com/34ksav36 #Macroautophagy#BrumellLab
Want to learn more about macromolecular complexes? Register for our webinar on 𝗝𝘂𝗹𝘆 𝟵𝘁𝗵, 𝟮𝟬𝟮𝟱! Discover more about our latest updates including the Complex Navigator & the integration of ML-predicted complexes (huMap3.0 & MuSIC). ➡️ Register:tinyurl.com/bdy6wttv
UniProt is a world-leading, freely accessible data resource that provides protein sequence and functional information to scientists worldwide. So what is the value of UniProt for the global scientific community? #FAIRdata #Bioinformatics
UniProt is a world-leading, freely accessible data resource that provides protein sequence and functional information to scientists worldwide. So what is the value of UniProt for the global scientific community? #FAIRdata #Bioinformatics
IntAct's dataset of the month features 75 cancer-associated missense variants in retinoblastoma tumor suppressor protein (PMID:39938803). Visit IntAct & explore detailed expert-curation of variants, binding domains and biophysical parameters (tinyurl.com/4rsx8754). #Cancer
Now published in @MolSystBiol embopress.org/doi/full/10.10…
May is skin cancer awareness month! We're highlighting Telomerase holoenzyme complex (CPX-265) featuring TERT(UniProt:O14746). See the complex in tinyurl.com/mt7u4wbs & visit UniProt for all melanoma-associated proteins tinyurl.com/mryjvyu7 #MelanomaAwareness, #SunSafety🧴
It is Skin Cancer awareness month! Explore manually curated interactomes of proteins associated with familial melanoma in IntAct. Access the network in IntAct (tinyurl.com/26tc7xtm). #IntAct_EBI, #ComplexPortal, #UniProt, #MelanomaAwareness, #SunSafety, 😎📷🧴
Thrilled to announce that the protein–protein interactions of 396 SLC transporters, from the RESOLUTE project, is now integrated into IntAct! Congratulations to #Superti-FurgaLab, #FabianFrommelt Explore the interactome at ebi.ac.uk/intact/search?…
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EMBL-EBI Training @EBItraining
17K Followers 577 Following Offering #bioinformatics training on-site at @emblebi, online, and at institutes around the world. 🏷️ Tag us in content: #EBItraining 📧 [email protected]
Protein Data Bank @PDBeurope
22K Followers 800 Following PDBe is a founding member of the wwPDB. The PDBe team is also responsible for the PDBe-KB, AlphaFold DB and 3D Beacons resources.
UniProt @uniprot
11K Followers 567 Following UniProt is the central hub for the collection of functional information on proteins, with accurate, consistent and rich annotation.
EMBL-EBI @emblebi
73K Followers 573 Following EMBL-EBI provides open biological data resources and tools, and performs basic research in computational biology. https://t.co/wA8UjwM0hd
Ensembl @ensembl
29K Followers 244 Following The Ensembl project seeks to enable genomic science by providing high quality, integrated annotation.
Nature Biotechnology @NatureBiotech
319K Followers 2K Following Publishing the best of biotech science and business. Find us on Bluesky, Facebook & Instagram. Part of @SpringerNature and @NaturePortfolio.
EMBL Events @EMBLEvents
28K Followers 1K Following 🧬 Join our world-class courses, conferences, and workshops at the forefront of molecular life science. 👩🏻🔬🔬 🦋 https://t.co/irPhwa0pCs
GlobalBiodata @globalbiodata
807 Followers 289 Following The Global Biodata Coalition convenes the world’s life science research funders to address the challenge of sustainable funding for biodata resources globally.
Ewan Birney @ewanbirney
48K Followers 2K Following Deputy Director General of EMBL, Director of EMBL-EBI. I have an insatiable love of biology. @[email protected]. I also work with ONT, Dovetail + GeL.
ELIXIR Europe @ELIXIREurope
10K Followers 1K Following Research infrastructure bringing together Europe's #bioinformatics resources. Store, analyse, share, & reuse data
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2.6M Followers 3K Following Research, News, and Commentary from Nature, the international science journal For daily science news, get Nature Briefing: https://t.co/wGmQlQ8a4D
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5K Followers 560 Following Account of the Saez-Rodriguez lab at Heidelberg University Lab members tweet about our news, activities & publications Also at: https://t.co/YFqkPcH6dY
EMBL @embl
67K Followers 920 Following The European Molecular Biology Laboratory drives visionary basic research and technology development in the life sciences. 🦋 https://t.co/r840DbdMXO
Gene Ontology @go@gen... @news4go
3K Followers 223 Following The Gene Ontology project provides a controlled vocabulary to describe gene and gene product attributes in any organism. Not active on Twitter, check 🦋 & 🐘
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