IT'S OUT:Our paper on elective nodal irradiation mitigates local and systemic immunity generated by combination radiation + immunotherapy in head and neck tumors. Link: nam02.safelinks.protection.outlook.com/?url=https%3A%…
Happy to share our external validation work on radiation DV constraints of the thyroid gland for #HNC out in the #greenjournal ☢️
While keeping VS60 above 10cc should limit 5-year primary hypothyroidism risk to <15%, ALARA remains the golden rule.🏅
#radonc#savethethyroid
Phase III trial of whole neck RT vs upper neck RT in uninvolved neck in #NPC. New SOC.
Excellent oncologic outcomes. Less hypothyroidism, late dysphagia and late soft tissue toxicity.
NB. Same in patients unfit for chemotherapy❓
thelancet.com/journals/lanon…
Prof Bourhis presenting REACH GORTEC trial at #ESMO21
Avelumab fails to improve outcomes for locally advanced head and neck cancer pts combined w/ cetuximab/radiotherapy.
possible PFS signal in unfit pts
Unfortunately IO is still disappointing in HNC patients…
#hncsm#radonc
Last update of the MACH-NC individual patient data meta-analysis of chemo for locally advanced HN Cancers is out here: bit.ly/31f2d0L
Massive collaborative effort, with lots of details (75p supplementary appendix for those interested...).
#radonc#hncsm
THREAD below
HN002 out in JCO @sueyom
Random ph II, 306 pts p16+ T1-T2 N1-N2b or T3
N0-N2b OPSCC <10 PY. IMRT 60 Gy +/- Cis
Weekly Cis at 2y
⬇️LR failures (3.3 vs 9.5%)
↔️OS & DC
⬆️ acute G3/4 tox
↔️ late G3/4 tox & MDADI
60Gy+Cis selected for ph III
Full text at bit.ly/3t6BjEQ
Out now in @JNCI_Now (academic.oup.com/jnci/advance-a…)! @sloan_kettering H&N team’s work on Precision Radiotherapy for HPV+ HNSCC: **30Gy** for definitive treatment! Spear-headed by @imrtlee & Eric Sherman, & and an all-star translational cast (JRF, SNP, TC, & more). #radonc#hncsm (1/N)
Do we overtreat nasopharyngeal cancer in the era of IMRT? This review explores de-intensification approaches with 1) systemic tx 2) radiation tx 3) EBVDNA-directed tx 4) imaging biomarkers and 5) immunotherapy. #hncsm@AnnaLeeMDMPH@jameschowch@imrtleeja.ma/2WIBreR
Wonderful time Zoom-speaking in #CUHKMedicine ENT Conference on immunotherapy for #OSCC. Also enjoyed very much the keynote lecture by @AriRosenbergMD on novel organ-preservation approaches - surprised to see our similar choices of preclinical and clinical data!
Delighted to share on behalf of the #HKNPCSG our study on second malignancy after #IMRT for #NPC in a decade-long territory-wide cohort.
Excess cancer risk exists in most irradiated head and neck organs. Watch these out esp in longterm #survivors!
authors.elsevier.com/a/1boSY4tFDI9o…
Given the recent negative results in locally advanced HNC with avelumab and pembrolizumab, this paper demonstrates the potential deleterious effect of large volume lymph node irradiation. Do we need to radiate the entire neck?
cell.com/cancer-cell/fu…
Interesting data at #ESMO2020 -- suggesting RT+Anti-PD1 concurrently may not be straight forward. JAVELIN HNSCC negative for CRT+/-Avelumab; Small GORTEC study showing no improvement in outcomes with Pembro vs. Cetux (low bar!).Concurrent the wrong direction? Or too early yet?
Congrats to @YG_TAO presenting GORTEC 2015-01
133 locally advanced HNC cisplatin unfit pts randomized to #radiotherapy with #cetuximab or #pembrolizumab
Less tox with pembro-RT but no diff in locoreg control, PFS or OS
Awaiting for larger trials...
#ESMO20#hncsm#radonc
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4K Followers 306 FollowingThe American Head and Neck Society is the single largest organization in North America for the advancement of research and education in head and neck oncology.