Jonathan Chou @jonchou05
San Francisco, CA Joined March 2016-
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Thanks to @UCSFCancer for covering our study which showed that a PPARg agonist rosiglitazone (an old diabetes drug) can modulate NECTIN4 & enhance activity of a new CAR T in #bladdercancer @CChuMD @koshkin85 @DrTFriedlander @SimaPorten @UCSFUrology ucsf.edu/news/2025/09/4…
Research funded in part by BCAN with @jonchou05 in @NatureComms : Modulating the PPARγ pathway upregulates NECTIN4 and enhances chimeric antigen receptor (CAR) T cell therapy in bladder cancer. Click here to read the article: nature.com/articles/s4146…
In @NatureComms: Bladder cancer variants share aggressive features including a CA125+ cell state and targetable TM4SF1 expression. Click here to read the article: nature.com/articles/s4146…
UCSF BCAN community really showed up for our walk this year, babies and 4 legged friends alike, to support our patients with bladder CA and raising $40k for research. No one walks alone 🧡@bcan_chisolm @UCSFCancer @UCSFUrology @SimaPorten @jonchou05 @koshkin85 @SamWashUro
📢Check out this Article NOW ONLINE! @NatureCancer '#Transcription and #DNAreplication collisions lead to large tandem duplications and expose targetable #therapeutic vulnerabilities in #cancer' ✏️By Jonathan Chou, Lixing Yang and colleagues 📎nature.com/articles/s4301…
🔥 Hot off the press: Lixing Yang, PhD, and collaborators at @UCSF have published a ground breaking work in @NatureCancer, demonstrating how unrepaired collision of DNA replication and transcription can drive aggressive cancers. @UChicagoCCB @jonchou05 ow.ly/VkTT50U9bYt
📕 New publication alert: Lixing Yang, PhD and his collaborators at @UCSF published an exciting work demonstrating new approaches to correct the errors generated by the collision of DNA replication and transcription. @jonchou05 @NatureCancer @UChicagoCCB ow.ly/QEtK50UahjS
In prostate cancer, sensitivity to poly ADP-ribose polymerase inhibitors is dependent on the specific type and zygosity of the CDK12 mutation, reports Dr. Jonathan Chou's team at @UCSF. bit.ly/3zBmdzq
Thanks @jonchou05 for visiting @fredhutch fantastic talk & dinner! @HsiehLab @li_haolong @DrOmarMian @JLWrightMD @koshkin85 @GavinHa @DrTFriedlander @BladderCancerUS @Uromigos @JoshMeeks @TiansterZhang @jklee_lab @FaltasLab Great opportunities for collaboration & translation!
Thanks @jonchou05 for visiting @fredhutch fantastic talk & dinner! @HsiehLab @li_haolong @DrOmarMian @JLWrightMD @koshkin85 @GavinHa @DrTFriedlander @BladderCancerUS @Uromigos @JoshMeeks @TiansterZhang @jklee_lab @FaltasLab Great opportunities for collaboration & translation!
Histologic variants in bladder cancer harbor aggressive molecular features including TM4SF1 expression and a CA125+ cell state biorxiv.org/cgi/content/sh… #biorxiv_cancer
We are happy to share our new study published today @JCO_ASCO (👉 ascopubs.org/doi/10.1200/JC…) on the role of NECTIN4 amplifications to predict responses to Enfortumab Vedotin treatment in metastatic urothelial cancer. With a huge contribution of our multinational team we uncovered…
@scserendipity1 @JCO_ASCO @PTarantinoMD @ASCO @urotoday @OncoAlert @imedverse @Markuseckstein3 Thanks @scserendipity1 We and others (aacrjournals.org/clincancerres/…) believe yes: Membranous NECTIN4 expression is correlated to EV response. Further, app. 40% of oUC metastatic samples are lacking membranous NECTIN4 aacrjournals.org/clincancerres/…
Nectin4 amplification predicts response to enfortumab vedotin in metastatic urothelial carcinoma - @PTarantinoMD @niklas_kluemper #BreastCancer #DanaFarberCancerInstitute #GU24 #HER2 #ExperimentalOncology #LungCancer oncodaily.com/32899.html
Great overview on UC pathology @Markuseckstein3 🔥 important to keep these pathways of UC carcinogenesis in mind for ADC targets as well, as NECTIN4 is overexpressed in luminal tumors as nicely demonstrated by @jonchou05 pubmed.ncbi.nlm.nih.gov/34108177/ in @CCR_AACR @urotoday @OncoAlert
Great overview on UC pathology @Markuseckstein3 🔥 important to keep these pathways of UC carcinogenesis in mind for ADC targets as well, as NECTIN4 is overexpressed in luminal tumors as nicely demonstrated by @jonchou05 pubmed.ncbi.nlm.nih.gov/34108177/ in @CCR_AACR @urotoday @OncoAlert
Our latest paper ist out in @Histo_Journal ! We comprehensively studied the membranous protein expression of the two important #ADC targets TROP2 and NECTIN4 (surfaceome 🏄♂️). it is the first paper on protein expression in a large cohort of over 200 muscle-invasive and metastic…
Awesome showing by @UCSFCancer at #BCANTT23 Thank you to @SimaPorten and many of our colleagues @UCSFHospitals including also @friedt02 @Tanjin097 @jonchou05 @xiaolin_zhu @HemoncUcsf @ckcding and our NPs Iva Colon and Krisztina Emodi @BladderCancerUS
Awesome showing by @UCSFCancer at #BCANTT23 Thank you to @SimaPorten and many of our colleagues @UCSFHospitals including also @friedt02 @Tanjin097 @jonchou05 @xiaolin_zhu @HemoncUcsf @ckcding and our NPs Iva Colon and Krisztina Emodi @BladderCancerUS
Team UCSF at the 2023 BCAN Think Tank! Blessed to have such amazing colleagues and friends @CChuMD @koshkin85 @ckcding @SamWashUro @HeikoYangMDPhD #BCANTT23
Excited to see our B7-H3 paper published by STM today! Many thanks for all lab members, collaborators and funding sources! @Wei_Shi90 @BradStCroix @aaparicioMD @MDAndersonNews @PCFnews @CPRITTexas @NIH science.org/doi/10.1126/sc…
Exciting new study out of @UCSFCancer Michael Evans @jonchou05 et al: Theranostic Targeting of CDCP1 in Multiple Subtypes of Bladder Cancer with Lu177 tinyurl.com/4tydrx87
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208 Followers 454 Following NIH/NCI Hem/Onc Fellow starting July 2022| UGSP/iCURE Alum| GU cancers (NIH GU w Andrea Apolo) , cancer epigenetics| Views = my own
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DrTylerStewart @DrTylerStewart
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EllisLab_ @EllisLab_
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Nature Methods @naturemethods
151K Followers 1K Following Nature Methods publishes cutting-edge methods, tools, analyses, resources, reviews, news and commentary, supporting life sciences research. Tweets by editors.
Science Advances @ScienceAdvances
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nature @Nature
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10K Followers 2K Following A Comprehensive Cancer Center designated by @theNCI for 50+ yrs. #NothingWillStopUs #NCIDesignated #UChiCancer50 @UCMOCECHE https://t.co/RDULLZ8a8j
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