The Colombo Lab @lab_colombo
Giorgio Colombo's Computational Chemistry and Biology Lab; Always Room for Improvement; University of Pavia, Italy. @lab-colombo.bsky.social tinyurl.com/3y2vbn4y The University of Pavia Joined April 2020-
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The Colombo Lab retweeted
In memory of Len Neckers, whose pioneering work on #HSP90 and #PTMs laid the foundation for how we think about chaperone regulation. Our latest @TrendsBiochem review builds on this legacy to explore the formation and function of #epichaperomes. doi.org/10.1016/j.tibs…
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The Colombo Lab retweeted
Online now! Design of multi-target peptide modulators for protein chaperone networks dlvr.it/TMgycc
🚀New adventures in #DrugDiscovery: We designed multitarget leads that hit Hsp70, Hsp90 & Cdc37 at once—disrupting chaperone networks that fuel tumor growth. Collaboration with @MedMol, @GestwickiLab Labs #CancerResearch #CompChem @AirC @Structure_CP shorturl.at/gGk7m
The Colombo Lab retweeted
Impact of Genetic Variants Associated with Neurodevelopmental Disorders on the WAVE Regulatory Complex pubs.acs.org/doi/10.1021/ac… @DeRubeisLab @lab_colombo #JCIM Vol65 Issue14 #Letter
The Colombo Lab retweeted
#descriptoroftheday #moleculardescriptors #qsar #cheminformatics #alvatips Intrinsic state pseudoconnectivity indices have been described in "Modeling with Molecular Pseudoconnectivity Descriptors. A Useful..." doi.org/10.1021/jp0011… Check #alvaDesc at: alvascience.com/alvadesc/
The Colombo Lab retweeted
It takes two to tango! Here our latest two works exploring the roles of TRAP1 in tumor biology ! @arasola @dsb_unipd @LaviniaFerrone @FilomeniL @lab_colombo
The Colombo Lab retweeted
Exciting to share our latest work now out on RedoxBiology! A stimulating journey with @arasola @FilomeniL @lab_colombo @LaviniaFerrone @dsb_unipd Disulfide-mediated tetramerization of TRAP1 fosters its antioxidant an... sciencedirect.com/science/articl…
The Colombo Lab retweeted
Inhibition of sperm-egg interaction through a synthetic water soluble analogue of seminolipid. Towards the development of a non-hormonal contraceptive? Check it out! @LaStatale @LPanza61249 @lauramorelli5 #glycotime #glycochemistry #glycolipids mdpi.com/3281030
The Colombo Lab retweeted
💡Featured by @MSKLibrary: Phosphorylation-driven epichaperome assembly is a regulator of cellular adaptability and proliferation Our recent publication in @NatureComms - check it out! #Phosphorylation #Epichaperome #HSP90 #PrecisionMedicine dx.doi.org/10.1038/s41467…
See our latest paper in @NatureComms, by @LucaTorielli @FedericaGuarra Stefano Serapian @GestwickiLab. We show how pathogenic mutations disrupt dynamics, rewire allosteric routes and impair function in chaperone Hsp60. #CompChem #MolecularBiology nature.com/articles/s4146…
The Colombo Lab retweeted
How do stressors remodel #brain function before symptoms emerge? &network-centric intervention strategies as a promising avenue for disease-modifying #therapy in AD #Alzheimers #epichaperomes #neuroscience #SystemsBiology #networkbiology #drugdiscovery researchsquare.com/article/rs-593…
Read our latest research with @arasola on how mutations on the mitochondrial protein TRAP1 impact its function and cancer related activities, published with @SpringerNature on Cell Death and Disease in rdcu.be/edidL
Happy to share our latest work "Large-scale energy decomposition for the analysis of protein stability". We use simple simulations to predict the impact of mutations on stability of more than 250 mutants in different folds. doi.org/10.1016/j.cstr… #CompChem #CompBiol #AI #Biotech
The Colombo Lab retweeted
A friendship from childhood goes a long way - sometimes even to a paper in JACS😎I was fortunate to take part in this fantastic work of @TomSolomek and his team, combining their passion for strained compounds and photocages @UZH_Chemistry @HimsUva @snsf_ch
A friendship from childhood goes a long way - sometimes even to a paper in JACS😎I was fortunate to take part in this fantastic work of @TomSolomek and his team, combining their passion for strained compounds and photocages @UZH_Chemistry @HimsUva @snsf_ch
The Colombo Lab retweeted
My postdoc, Iris Guo, and I will offer an online course in February/March 2025, applied machine learning in chemistry. I will have five spots for students outside TU Berlin. Students from underrepresented groups will have priority. More info: anunesalves.owlstown.net/courses/3547-a… #compchem
The Colombo Lab retweeted
To be or not to be an oxidase? 🧪 Dive into our latest exploration of this classic enzymatic conundrum, now published in @ACSCatalysis: 10.1021/acscatal.4c05944. Grateful for the fantastic collaboration with @lab_colombo, @dirktischler, and @fraaije1!
The Colombo Lab retweeted
Re-upping this ad for a #postdocposition in our lab 🧠 🧬🔬 RT appreciated 🙏
Re-upping this ad for a #postdocposition in our lab 🧠 🧬🔬 RT appreciated 🙏
The Colombo Lab retweeted
This is what happens when you let computer scientists design molecules 🤯 Oral presentation @NeurIPSConf #NeurIPS2024
The Colombo Lab retweeted
Special Issue #ProteinNetworks by @lab_colombo Dr. Fuxreiter @UniPadova Dr. Emili @CNSB_OHSU Dr. Kastritis @3Dstructure @DinaSchneidman @cxarramirez @RichardDoveston Dr. Vlassakis @Rice_BIOE Dr. Nyarko @OregonState @CerdaLab Dr. Komives @UCSanDiego @ionpetr @chiosislabmskcc et al
The Colombo Lab retweeted
Design and Test of Molecules that Interfere with the Recognition Mechanisms between the SARS-CoV-2 Spike Protein and Its Host Cell Receptors pubs.acs.org/doi/10.1021/ac… @Francesca3995 @Ionica_Masgras @cla_laq @lab_colombo @arasola @eli_moroni @UniPadova #JCIM Vol64 Issue21 #compchem
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