Guo Lab (Sheffield) @lab_guo
The Guo Lab aims to understand the basic cell stress mechanisms associated with protein post-translational modifications in Health and Disease sheffield.ac.uk/bms/research/g… Sheffield, England Joined June 2019-
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For fun: 'Mature SUMO' youtube.com/watch?v=GuOERA…
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"PINK1 SUMOylation regulates basal mitophagy" biorxiv.org/content/10.110…
To meet, learn and discuss: an exciting meeting for sure 😊 protein-degradation.org/symposium/
meetings.embo.org/event/25-sumoy… EMBO Workshop SUMOylation: From discovery to translation 22 – 25 September 2025 | La Grande Motte, France I am sure this will be a good one😊.
Happy to be part of the team 🥰 " ... C.G. first identified MFF as a SUMO substrate. . All authors contributed to editing the manuscript." Another set of evidence highlighting SUMO's regulatory function in mitochondrial fission science.org/doi/10.1126/sc…
SENP3 knockout mice exhibit embryonic lethality at day 8.5, characterised by a neural tube defect and abnormal cardiac asymmetry (left-sided). sciencedirect.com/science/articl…
MiDs - MFF - DRP1 actions in mitochondrial fission nature.com/articles/s4155…
"Overall, base editor screening of PTM sites provides a powerful platform to dissect PTM function within signaling pathways." nature.com/articles/s4159…
Collaboration between the mitochondria and the nuclei in protein making cell.com/molecular-cell…
Chronic but not acute nicotine treatment ameliorates acute inflammation‐induced working memory impairment by increasing CRTC1 and HCN2 in adult male mice - Wang - 2024 - CNS Neuroscience & Therapeutics - Wiley Online Library onlinelibrary.wiley.com/doi/10.1111/cn…
SENP3 again⁉️ 🧐 "In Alzheimer’s disease (AD), the BLA base model 654 identified seven AD-associated genes (DTX1, C3orf37, MEX3C, INPP1, USP32, YPEL2, SENP3)" biorxiv.org/content/10.110…
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