Mike Weedon @mnweedon
Professor in Bioinformatics and Human Genetics working with @diabetesgenes and @T2Diabetesgenes at #ExeterDiabetes University of Exeter, UK Joined December 2013-
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Excellent first annual meeting of the Wellcome PARADIGM team, paradigmgenomics.org. We shared some exciting science and had fun along the River Exe! @ensembl @deciphergenomic @tisimpson @HelenVFirth @PsyEpigenetics @jmarshlab @drjamesware @ExeterMed
Nice end to the week - another paper out! Lovely work from @rnbeaumont1 looking at clustering of predicted loss-of-function variants in @uk_biobank; explains incomplete penetrance in some dev disorder genes. genomemedicine.biomedcentral.com/articles/10.11…
I absolutely love examples of human genetics informing drug adverse effects. A fascinating new example I learned today, thanks to @wllmsb for pointing to me. Many would be familiar with the immune checkpoint inhibitors used in the treatment of many cancers…
I absolutely love examples of human genetics informing drug adverse effects. A fascinating new example I learned today, thanks to @wllmsb for pointing to me. Many would be familiar with the immune checkpoint inhibitors used in the treatment of many cancers…
In UK Biobank, individuals who had high polygenic score for educational attainment but performed poorly in fluid intelligence test and/or had poor education ('deviators') were more likely to carry neurodevelopmental disorder-related rare variants. Great demonstration of liability…
Thanks for a splendid meeting in Exeter👏🏻😃 #sggdexeter2024 Next time 2026 in Bergen😀 #sggdbergen2026
Fabulous few days at #SGGDExeter2024, with some inspiring science, people and views! Enjoyed talking about DDD and learning about diabetes genetics. Thanks @mnweedon @flanagan_se for a great meeting.
Honoured, although the cat couldn’t care less, to have been awarded a prize for one of the top talks at #SGGD2024 A great meeting with some spectacular science
Thank you to the #SGGDExeter2024 organizing team for this great meeting!
Congratulations to @ailsamaccalman1 for winning the prize for one of the highly commended oral presentations at #SGGDExeter2024! What a ⭐️ @PsyEpigenetics @nickdlowens
Award winner and highly commended winners of the short talks!! #SGGDExeter2924 @Sarah_Finer @KsMoneeza Miriam Samuel takes away the top prize!
It was an inspirational and extremely important part of the conference, thank you so much @tomstaniford #SGGDExeter2024 (great jokes too!)
It was an inspirational and extremely important part of the conference, thank you so much @tomstaniford #SGGDExeter2024 (great jokes too!)
Great view, great science, great meeting! #SGGDExeter2024
Great #SGGDExeter2024 , charming Exeter!
@TomLaver is flying the flag for #congenitalhyperinsulinism #SGGDExeter2024. Great to see him showcase the team’s work on low level mosaic variants in CHI. A study made possible through generous @MDBRide4Rare grant funding @congenitalhi
Additive effect of carrying multiple rare variants in monogenic DDG2P genes and common variant polygenic score for educational attainment in @uk_biobank. Lovely work from former PhD student Becca Kingdom with @mnweedon @ExeterMed @NatureGenet doi.org/10.1038/s41588…
It’s day 2 of the #SGGDExeter2024 meeting. @DrElisaDeFranco kicks off today’s sessions with a fantastic talk describing recent genetic discoveries in Neonatal Diabetes.
All set up and ready to welcome over 190 delegates to Exeter. Looking forward to three days of talks and discussions on the genetics of diabetes (and hyperinsulinism!). The sun has even made an appearance for us. #SGGDExeter2024
Come and join us in wonderful Devon. Lots of fantastic translational research opportunities with the @ExeterMed and @ExeterBRC genomics teams including @carolinefwright, @mnweedon, @PsyEpigenetics, @AnnaM1966, @ExeterGenomes @JoeLeslie95 and many others! Don't miss the deadline!
Come and join us in wonderful Devon. Lots of fantastic translational research opportunities with the @ExeterMed and @ExeterBRC genomics teams including @carolinefwright, @mnweedon, @PsyEpigenetics, @AnnaM1966, @ExeterGenomes @JoeLeslie95 and many others! Don't miss the deadline!
Would you believe me if I told you that a single variant in a non-coding RNA explains ~0.5% of all undiagnosed individuals with neurodevelopmental disorders (NDD) in @GenomicsEngland ??? I didn’t initially either, but here is the story of RNU4-2 🧵1/9
Would you believe me if I told you that a single variant in a non-coding RNA explains ~0.5% of all undiagnosed individuals with neurodevelopmental disorders (NDD) in @GenomicsEngland ??? I didn’t initially either, but here is the story of RNU4-2 🧵1/9
Happy to share that my paper on smoking during pregnacy on placental weight has been published 🎉 Many thanks to everyone who was involved in this work! @rmfreathy, @jack_bowdenjack, @KrasiTsaneva, @mvaudel, @stejo_bergen, @BoJacobsson, @PalRNjolstad …pregnancychildbirth.biomedcentral.com/articles/10.11…
Cecilia Lindgren @ceclindgren
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4K Followers 762 Following Prof of Pediatrics & Genetics 🧬 - Translational Genomics of Diabetes Lab #diabetes, #genetics #islets #womeninStem #teamscienceJonathan Mill @PsyEpigenetics
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21 Followers 53 FollowingKatie Partridge @Partridge2019
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592 Followers 3K Following Head of Strategic Relationships Science Operations Wellcome Sanger InstituteSpencer Moore @SponceyM
193 Followers 952 Following Interested in statistics, genetics and meta-science. Former: @IBG_CUBoulderNice end to the week - another paper out! Lovely work from @rnbeaumont1 looking at clustering of predicted loss-of-function variants in @uk_biobank; explains incomplete penetrance in some dev disorder genes. genomemedicine.biomedcentral.com/articles/10.11…
In UK Biobank, individuals who had high polygenic score for educational attainment but performed poorly in fluid intelligence test and/or had poor education ('deviators') were more likely to carry neurodevelopmental disorder-related rare variants. Great demonstration of liability…
Now added Feel free to give it a go!
We take glm from ~11-12 hours for 20 million variants to 1.5 minutes using a single machine. Should be useful for computation in virtual machine environments
For those #SGGDExeter2024 attendees who stayed the weekend Devon weather complied! Spring is (finally!!) springing!!
Whilst in Exeter, dropped by to see the lab besties 17 years later - not much has changed… #SGGDExeter2024
Thanks for a splendid meeting in Exeter👏🏻😃 #sggdexeter2024 Next time 2026 in Bergen😀 #sggdbergen2026
Fabulous few days at #SGGDExeter2024, with some inspiring science, people and views! Enjoyed talking about DDD and learning about diabetes genetics. Thanks @mnweedon @flanagan_se for a great meeting.
Had an awesome time at #SGGDExeter2024 this week. Thanks, @mnweedon, @flanagan_se, @athattersley, and team for organizing a great meeting! Greatly enjoyed seeing so many great people and learning with all of the fantastic talks!
Honoured, although the cat couldn’t care less, to have been awarded a prize for one of the top talks at #SGGD2024 A great meeting with some spectacular science
Thank you to the #SGGDExeter2024 organizing team for this great meeting!
Really pleased to have been able to present our work on the genetic aetiology underlying the Diabetes-Blood Pressure relationship at the wonderful SGGD conference in beautiful Exeter! I had a great time, lots of inspiring talks. Big thanks to the organisers! #SGGDExeter2024
Congratulations to @ailsamaccalman1 for winning the prize for one of the highly commended oral presentations at #SGGDExeter2024! What a ⭐️ @PsyEpigenetics @nickdlowens
Award winner and highly commended winners of the short talks!! #SGGDExeter2924 @Sarah_Finer @KsMoneeza Miriam Samuel takes away the top prize!
It was an inspirational and extremely important part of the conference, thank you so much @tomstaniford #SGGDExeter2024 (great jokes too!)
Had the honour of speaking at the Study Group on Genetics in Diabetes conference dinner this evening, for @athattersley @MaggieShepher13 @RAOram and other luminaries. They very kindly got me this snazzy cycling jersey
Great view, great science, great meeting! #SGGDExeter2024
Great #SGGDExeter2024 , charming Exeter!
Pre-dinner drinks at the SGGDExeter2024 meeting. Gorgeous views over the rolling Devon countryside
@TomLaver is flying the flag for #congenitalhyperinsulinism #SGGDExeter2024. Great to see him showcase the team’s work on low level mosaic variants in CHI. A study made possible through generous @MDBRide4Rare grant funding @congenitalhi
Happy to share my work on the glycaemic and non-glycaemic determinants of HbA1c during and outside pregnancy at #SGGDExeter2024 @ExeTeamBW
Additive effect of carrying multiple rare variants in monogenic DDG2P genes and common variant polygenic score for educational attainment in @uk_biobank. Lovely work from former PhD student Becca Kingdom with @mnweedon @ExeterMed @NatureGenet doi.org/10.1038/s41588…