Shi Yan @mryanshi
biochemist, glycobiologist, biotech enthusiast, interested in infectious diseases and cancer #glycotime orcid.org/0000-0003-4949… Vienna, Austria Joined January 2016-
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Shi Yan retweeted
Excited to share the first paper from my lab in @Nature ! We repurposed the widely used research tool, proximity labeling, to demonstrate its therapeutic potential in antigen amplification for immunotherapy using mouse tumor models and patient samples. nature.com/articles/s4158…
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Shi Yan retweeted
The key molecules in immune responses are glycoproteins. Why isn't glycosylation studied more intensively? It should be. It's a challenging research area, but a good one for ambitious & audacious scientists.
Shi Yan retweeted
🦠 The RVC, working with the University of Veterinary Medicine & the University of Natural Resources and Life Sciences, have developed the first laboratory-made vaccine to protect livestock against the Barber’s Pole worm parasite ➡️ Read more at: rvc.uk.com/livestock-para…
Shi Yan retweeted
Did you know amphibians and fish have viruses that are very similar to human influenza B viruses? We didn't know either, but Eddie Holmes found them and we had a closer look at their HAs and NAs. with @gabagagan @WardLab1 @RobertPdeVries1 @dishabhavsar science.org/doi/10.1126/sc…
Glycocalyx dysregulation impairs blood–brain barrier in ageing and disease | Nature #glycotime #ageing nature.com/articles/s4158…
Shi Yan retweeted
My PhD work is out in @NatureComms !✨For the first time, we show that bacteria can glycosylate full-length monoclonal antibodies. A proof of concept and a key step toward making antibody therapies accessible to all.. nature.com/articles/s4146… #biotech #glycotime #SyntheticBiology
Shi Yan retweeted
New from our lab: @k_mikolajczyk @katszymczak et al. show which expression system is better for glycosylated proteins: Trichoplusia ni insect cells (High Five) or human embryonic cells (Expi293F). Location of the 6xHis-tag also evaluated. tinyurl.com/2xkmxtet #glycotime
Shi Yan retweeted
涙の糖プロテオームの詳細な解析により、ラクリチンの多様な糖鎖付加とスプライソフォームが明らかに #glycotime In-depth analysis of the tear fluid glycoproteome reveals diverse lacritin glycosylation and spliceoforms - Journal of Biological Chemistry jbc.org/article/S0021-…
Shi Yan retweeted
I'm excited to share our paper detailing a new sensitive and accessible LC-MS method for analysis of GAGs and non-reducing end biomarkers for lysosomal storage disorders! This was a great collaboration with the Azadi and Boons groups @CCRCUGA! #glycotime pubs.acs.org/doi/10.1021/ac…
Shi Yan retweeted
Why does RNA undergo glycosylation? Excited to have our new paper out. We in collab w/ Ryan Flynn show N-glycans on glycoRNAs hide self-RNA from endosomal TLRs promoting ‘silent’ clearance of dead cells. nature.com/articles/s4158… @uconnhealth @UConnResearch
Many thanks for sharing our new #glycotime paper! A great team effort built on years of research on worm glycosylation, initiated in the Wilson lab @IainWil92988866. Proud to contribute by exploring its application in novel vaccine development. 💉🐏🐑🪱
Many thanks for sharing our new #glycotime paper! A great team effort built on years of research on worm glycosylation, initiated in the Wilson lab @IainWil92988866. Proud to contribute by exploring its application in novel vaccine development. 💉🐏🐑🪱
Shi Yan retweeted
👇Structure of the Lipopolysaccharide from Paenalcaligenes hominis: A Chemical Perspective on Immune Recognition | JACS Au #Paenalcaligenes #glycotime #Aging #Microbiota #Aging #GutBrainAxis #bacteria #immunity @FerranNieto14 @di_flaviana @MolinaroTony pubs.acs.org/doi/10.1021/ja…
Shi Yan retweeted
Cryo-EM of fertilisation complex Pfs230-Pfs48/45 from malaria parasites! 💕 🦟 Transgenic parasites without Pfs230 D13D14 do not transmit 🦙 💉Nanobodies + mRNA induced antibodies reduce transmission New in @ScienceMagazine science.org/doi/10.1126/sc… #ScienceResearch #Malaria
Shi Yan retweeted
New review paper from the influenza group @UtrechtVirology together with Mengying Liu and Erik de Vries on virion motility of sialoglycan-cleaving respiratory viruses through mucus and on cells in NPJ viruses @NaturePortfolio doi.org/10.1038/s44298…
Shi Yan retweeted
And now published! #glycotime "Sialic Acid-Containing Glycolipids Extend the Receptor Repertoire of Enterovirus-D68" fantastic collaboration with @LisaBauerVirus @DebbyvanRiel @TheBoonsGroup enjoy 👍pubs.acs.org/doi/10.1021/ac…
Shi Yan retweeted
🚨 Glyconeer® Workshop 2025 📍 Potsdam | 📅 July 2–4 We’re bringing together global #Glyconeer users, @MpiciPotsdam scientists & glycan enthusiasts for 3 days of insights, updates & exchange! Join the conversation on the future of automated glycan assembly! 💬✨ #glycotime
Shi Yan retweeted
New #JITC review: Tumor glyco-immunology, glyco-immune checkpoints and immunotherapy bit.ly/4lEMeQP
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