Peter Sims @psimslab
Associate Professor of Systems Biology | Columbia University columbia.edu/~pas2182 Joined May 2020-
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Excited to share our CITE-seq atlas of the aging human immune system across tissues. Great collaboration with @DonnaFarber3, @YosefLab, @teichlab, Jo Jones @Cambridge_Uni and partnership with @cziscience! nature.com/articles/s4159…
In a new study, @ColumbiaPS researchers discovered that mRNA COVID-19 vaccines prompt the immune system to store memory T and B cells—key for long-term immunity—in tissues like the lungs, spleen, and bone marrow. columbiamed.link/4eO8rI6
Another awesome collaboration with @DonnaFarber3! Among many other experiments, we profiled antigen-responsive T cells across the body for COVID vaccine and flu with CITE-seq. Will be interesting to see if these findings generalize to other viruses and vaccines!
Another awesome collaboration with @DonnaFarber3! Among many other experiments, we profiled antigen-responsive T cells across the body for COVID vaccine and flu with CITE-seq. Will be interesting to see if these findings generalize to other viruses and vaccines!
🧵1/9 Excited to share our latest research on human microglia! We explored microglial heterogeneity through single-cell RNA sequencing of 215,680 live human microglia from 74 donors across neurological diseases. #NeuroImmunology #Microglia @NatureNeuro nature.com/articles/s4159…
Single-cell RNA sequencing to profile 215,680 *living* human #microglia across neurological diseases and CNS regions identifies disease-enriched subsets and tool compounds recapitulating microglial states @TuddenhamJohn @HaageVc @MarikoTaga nature.com/articles/s4159…
Congratulations to Drs. @SaraZaccara and @dianyang1117. Well deserved!
Congratulations to Drs. @SaraZaccara and @dianyang1117. Well deserved!
Thank you to everyone who attended the Annual DSB Retreat. We hope that you had a wonderful, science-filled time. Congratulations to the Best Poster Winners.
And so it begins. This is required reading for all brain tumor docs. Vorasidenib: a new hope or a false promise for patients with low-grade glioma? | Nature Reviews Clinical Oncology nature.com/articles/s4157…
Very happy to see my main project from residency @ColumbiaNeuro finally out! Cool story on mitochondrial #metabolic vulnerabilities and #ferroptosis linked to #GBM cell states. So grateful for the support from Jeffrey Bruce @PCanoll @psimslab @bstockwell @kitaj_angio and others
Very happy to see my main project from residency @ColumbiaNeuro finally out! Cool story on mitochondrial #metabolic vulnerabilities and #ferroptosis linked to #GBM cell states. So grateful for the support from Jeffrey Bruce @PCanoll @psimslab @bstockwell @kitaj_angio and others
A cell state-specific metabolic vulnerability to GPX4-dependent ferroptosis in glioblastoma @psimslab @PCanoll @Columbia et al find quiescent astrocyte-like glioma cells show abnormal energy metabolism, sensitizing them to ferroptosis-inducing drugs embopress.org/doi/full/10.10…
Our collaborators @psimslab @raphg + @KenStuart18 create a "normalization" method for antibody-derived tags and integration across data sets. (Preprint) @researchsquare researchsquare.com/article/rs-457…
ICYMI: check out our lab's latest publication in Cell, where we discovered that FGFBP1 is a novel marker of stemness in the intestinal epithelium cell.com/cell/abstract/…
Fantastic work and great to see additional strong evidence of predominant 5-ALA metabolism by myeloid cells in GBM.
Congrats on preprint study from some of our collaborators. Shows strategy to cut batch effects + integrate single-cell protein measures across CITE-seq datasets. Authors include @yezhengSTAT @raphg @psimslab @biorxivpreprint #FOCIS24 biorxiv.org/content/10.110…
Congrats on preprint study from some of our collaborators. Shows strategy to cut batch effects + integrate single-cell protein measures across CITE-seq datasets. Authors include @yezhengSTAT @raphg @psimslab @biorxivpreprint #FOCIS24 biorxiv.org/content/10.110…
A few decades later, training is finally complete. A great feeling to celebrate the end of fellowship with such an amazing group of future oncologists. Honored to receive the Waun Ki Hong Award for Achievement in Basic Science Research. Thanks to all my mentors, friends and…
Well done @yezhengSTAT! This is a significant advancement for an often under-studied data type. Great to see a method specifically designed for CITE-seq data. Thanks to @cziscience and @hipcProject for their support. #CITEseq #DataScience #immunology
Well done @yezhengSTAT! This is a significant advancement for an often under-studied data type. Great to see a method specifically designed for CITE-seq data. Thanks to @cziscience and @hipcProject for their support. #CITEseq #DataScience #immunology
🚀 Exciting news! Check out our latest non-parametric strategy to eliminate batch effects and integrate single-cell protein measurements across CITE-seq datasets! Dive into the ✨ADTnorm✨ method details here: biorxiv.org/content/10.110… #CITEseq #Bioinformatics #Singlecell
We wrote a paper! γδ T cells do different things, in different tissues, at different times of your life @DonnaFarber3. Check it out. Thanks to all who helped get this together @Bruskolab @tconnors22 @psimslab @YosefLab @ImmunoEditor @SciImmunology
We wrote a paper! γδ T cells do different things, in different tissues, at different times of your life @DonnaFarber3. Check it out. Thanks to all who helped get this together @Bruskolab @tconnors22 @psimslab @YosefLab @ImmunoEditor @SciImmunology
Our study on human γδ T cells in mucosal and lymphoid tissues revealed increased frequencies, distinct functions, subsets, and site-specific compartmentalization in children compared to adults. with @JoshGray12 . Thanks to collaborators @Bruskolab @tconnors22 @psimslab @YosefLab
Our study on human γδ T cells in mucosal and lymphoid tissues revealed increased frequencies, distinct functions, subsets, and site-specific compartmentalization in children compared to adults. with @JoshGray12 . Thanks to collaborators @Bruskolab @tconnors22 @psimslab @YosefLab
Arjun Raj @arjunrajlab
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Sinibaldo R. Romero A... @mdphdintraining
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632 Followers 3K Following Interior Designer & Coffee Roaster House Flipper Traveler & Art Enthusiast Living life surrounded by beauty. Views are Mine https://t.co/5WnyQOVcjH https://t.co/RwFS8Yrkej
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NIH Funding @NIHFunding
55K Followers 34 Following Official account on NIH grants and funding information: funding opportunities, policy news, & more. https://t.co/mt3gbuKOjg Engagement ≠ endorsement
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Roham Parsa (rohampar... @rohamparsa
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WCM Englander Institu... @WCMEnglanderIPM
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