Stetson @stetson_thacker
Human genetics. Precision Oncology. Books. Anything that piques my curiosity. Opinions are my own. stetson.substack.com Cleveland, Ohio Joined July 2009-
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🇮🇹 The ROME trial marks a milestone for Italy’s precision oncology platform: 6 years of dedication, 40 centers, 1,794 patients sequenced. A national effort to bring genomics to the heart of cancer care. @myESMO @IEOufficiale @LaStatale
C, Map showing when and along which routes domesticated barley spread from its centre of origin in the Fertile Crescent. The grey shading indicates barley archaeological sites dating back about 7,000 years; the red shading indicates barley archaeological sites dating back about…
We know about 1000s of rare genetic neurodevelopmental disorders affecting millions of kids who present with ASD or ASD-like features. The “vast conspiracy” is lurking in our genomes — and can be taken down with personalized medicines if we only scaled tech that exists today
We know about 1000s of rare genetic neurodevelopmental disorders affecting millions of kids who present with ASD or ASD-like features. The “vast conspiracy” is lurking in our genomes — and can be taken down with personalized medicines if we only scaled tech that exists today
GPN-Star achieves unprecedented SNP heritability enrichments across over 100 human complex traits. Moreover, we devise a simple approach to incorporate tissue-specificity into the model prediction and show that it further improves heritability enrichment. (5/n)
In a study of ~2.5M children, there was a small association between in utero Tylenol use and subsequent autism. But the association disappears entirely when you introduce sibling controls, implying it’s spurious.
In a study of ~2.5M children, there was a small association between in utero Tylenol use and subsequent autism. But the association disappears entirely when you introduce sibling controls, implying it’s spurious. https://t.co/OTZimYfuso
We are excited to share GPN-Star, a cost-effective, biologically grounded genomic language modeling framework that achieves state-of-the-art performance across a wide range of variant effect prediction tasks relevant to human genetics. biorxiv.org/content/10.110… (1/n)
80% of AYAs (15–39y) have actionable biomarkers vs 59% adults Distinct biology ↓ exposure-driven muts, ↑ germline & molecular pathways CRC ↑ dMMR/MSI ≤39% <25y vs ~5% adults Breast ↑ BRCA1/2 (≤15%), TP53 & HRD (↑), 72% <35y high risk genomic vs 40% adults @OncoAlert 1/3
🚨 50 years of progress in NSCLC, beautifully captured in this JTO review! jto.org/article/S1556-… From the pre-cisplatin era to molecular profiling, targeted therapies, ICI, and advances in screening & supportive care. Half a century of lessons, half a century of survival —…
"majority of faculty under age 35 say they are in favor of shutting down speakers with whom they disagree..What terrifies the censors and cancellers..not that a dangerous idea might be thought, or even expressed, but that it might become common knowledge" a.co/d/26BFJNy
Our recent commentary on two very interesting preprints using long-read whole genome sequencing to uncover novel variants in ASD from @sebatlab and evan eichler labs. thetransmitter.org/spectrum/long-…
🚨 Our latest paper just came out in Science, where we report a simple, historical pattern: From 1980 to 2020, Republican lawmakers consistently funded science at a higher level than their Democratic counterparts. four years in the making. Led by @zfurnas thread 1/n
Tumor Lysis Syndrome @NEJM 2025 Incidence 5-70%, highest in acute leukemias & lymphomas. Now increasingly associated with targeted therapies & ICIs, even in solid tumors. ICIs >150 cases, 44% mortality Stratify risk, prophylaxis & act fast nejm.org/doi/full/10.10… @OncoAlert
Excited to share our preprint on PGI portability across ancestries—now on bioRxiv. With co-authors @AysuOkbay, @patrickaturley, @AlexTISYoung, @Dan_J_Benjamin. Preprint: doi.org/10.1101/2025.0… Thread below for details.
WGS analysis of ~2,700 Indians (largest to date) cell.com/cell/fulltext/… @CellCellPress - Most variation traced back to a single out-of-Africa event 50,000 years ago, with subsequent gene flow from Neanderthals & Denosivans. - All had a 4th degree relative or closer within the…
We’re excited to share our latest publication in @CellGenomics: “Streamlining Large-Scale Genomic Data Management: Insights from the UK Biobank Whole-Genome Sequencing Data”. Sincerely thanks to @drarwood, @muzizimumu1, @XihongLin, Yuxin Yuan, Gareth Hawkes, Robin Beaumont,…
We’re excited to share our latest publication in @CellGenomics: “Streamlining Large-Scale Genomic Data Management: Insights from the UK Biobank Whole-Genome Sequencing Data”. Sincerely thanks to @drarwood, @muzizimumu1, @XihongLin, Yuxin Yuan, Gareth Hawkes, Robin Beaumont,… https://t.co/KzJKGCBsAz
Here is our new preprint (medrxiv.org/cgi/content/sh…). We report heritability estimates for multiple traits using a within-family design in 500,000 sibling pairs of diverse ancestries! Fantastic collaboration with @23andMeResearch! Thanks to their participants and research team.
Impressive work from @LoicYengo estimating heritability with a huge sample of 23andMe siblings. They get height h2=0.71 (S.E. 0.02) for height (0.86 after assortative mating correction), 0.49 (SE 0.03) for BMI, and substantial h2 for smoking (0.34) and alcohol use (0.18).
Impressive work from @LoicYengo estimating heritability with a huge sample of 23andMe siblings. They get height h2=0.71 (S.E. 0.02) for height (0.86 after assortative mating correction), 0.49 (SE 0.03) for BMI, and substantial h2 for smoking (0.34) and alcohol use (0.18). https://t.co/cwdQTXXnXm
Aspirin is a wonder-drug It helps treat stroke and heart attack, kills pain and reduces fever, and can help prevent pre-eclampsia And (new evidence) low dose aspirin halves colorectal cancer recurrence after surgery in the ~40% of patients that carry PI3K mutations
The largest study on late life virginity, based on > 400k individuals, out now in @PNASNews Open access link: pnas.org/doi/10.1073/pn… Shoutout to shared first author @laurawesseldijk ❤️ Thread below 👇🏽

Justin Lathia, PhD �... @JustinLathia
7K Followers 2K Following Lab studying cancer from a stem cell and cell-cell interaction perspective, #cancerstemcells, #glioblastoma, #GBM. Tweets are my own. @DrexelUniv @NIHOxCam alum
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Veera Rajagopal @doctorveera
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Medical.watch @MedicalwatchFTW
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makingcolorblue @makingcolorblue
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100 Followers 2K Following minh bot tìm ban top fun nha ai choi hf kb zalo minh nha 0964379556
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Tina Han @tingfordha
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پونه محمودی... @PwnhM39023
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Angus Burns @anguscburns
373 Followers 368 Following Circadian rhythms | sleep | genetics | light ☄️— Research Fellow at Harvard Medical School & Broad Institute, Lane and Saxena labs
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66 Followers 550 Following Neuroscience Undergrad @uofmaryland | Visiting Student @neuraustralia | Exploring neurogenetics, psychiatry & biotech
Christopher John Lee @JunHongLi56447
100 Followers 1K Following I am a researcher engaged in psychometrics, Multi-omics, and Psychiatric Genetics. My hobby is studying the effects of accumulated mutation load. anti-ccp
tp53 (ashish) @inventcures
192 Followers 2K Following Boilermaker who loves walks, music and chai. Engineer who will invent a new cancer drug in his lifetime(wannabe oncologist !)
Curious Rum @Curious_Rum
186 Followers 510 Following
Nick the chopper 🏴... @ChopperThe3555
37 Followers 282 Following The content is the form 🏴🇬🇧 22
Simon Burns @SimonBurns_
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Griffin Pivateau @pivateau
130 Followers 1K Following Puterbaugh Professor of Legal Studies and Business Ethics at @SpearsBusiness. I get paid to think and write and teach. In that order.
Justin 🇨🇦 @JustinBellav
109 Followers 220 Following Statistical genetics grad student @UdeMontreal | OpenMTL events helper (link below) | Builder at heart
Jessica Dobrinsky @jldobrinsky
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fein @fein26052
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Ossian Longoria @OssianLongoria
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Edaoutau @Edaoutau276800
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Justin Lathia, PhD �... @JustinLathia
7K Followers 2K Following Lab studying cancer from a stem cell and cell-cell interaction perspective, #cancerstemcells, #glioblastoma, #GBM. Tweets are my own. @DrexelUniv @NIHOxCam alum
Case Comp Cancer Ctr @caseccc
3K Followers 1K Following Case CCC brings together @cwru, @UHhospitals, and @ClevelandClinic to unlock new possibilities in cancer research and transform the landscape of cancer care.
Nacho Mata @nachogenePD
2K Followers 1K Following neurogeneticist interested in understanding the genetic component of Parkinson’s disease (PD) and related disorders . Fighting for diversity in genetic studies
Nima Sharifi @NimaSharifiMD
4K Followers 964 Following Prostate Cancer Medical Oncologist & Scientific Director, Desai Sethi Urology Institute, Sylvester Cancer Center, University of Miami Miller School of Medicine
Veera Rajagopal @doctorveera
19K Followers 4K Following 🇮🇳 MBBS, MD, 🇩🇰 PhD | 🧬 Scientist @ 🇺🇸 Regeneron | Translating genetic insights into life-saving medicines | thoughts @ https://t.co/dTItNQy2BX
Razib Khan 🧬 ✍�... @razibkhan
82K Followers 4K Following Website: https://t.co/VmfV0t0M9a Founder: @genrait_inc Advise: @Get_Haiku @drydotai @AtheistsLiberty
Timothy Chan @GeneCollector
5K Followers 700 Following Chair, Global Center for Immunotherapy, Cleveland Clinic Health System, @ClevelandClinic; Professor of Medicine; fan of tennis, coral reefs, Legos; views my own
Philippe Lemoine @phl43
62K Followers 2K Following Technically a philosopher, still has a PhD to finish. I write about stuff. Directeur de la recherche à @Hexagone_org. "At least he's pretty smart." (@bechhof)
Cody Moser @LTF_01
8K Followers 983 Following Assistant Professor @TheSchoolofCI | PhD @UCMCogSci | Podcasting w/ @horizonsreview: collective intelligence, systems collapse, complex systems, networks, etc.
Eric Fauman (he/him) @Eric_Fauman
6K Followers 244 Following GWAS whisperer 'Nothing in biology makes sense except in the light of evolution' DMs open Executive Director, Integrative Biology @Pfizer
Robin Hanson @robinhanson
113K Followers 726 Following Let’s skip witty banter & talk deep Qs. Books: https://t.co/hpZgEm55Ma https://t.co/iFs9C3IuOM Chief Scientist @_futarchy Advisor @MetaDAOProject @butterygg
Aaron Sibarium @aaronsibarium
86K Followers 4K Following Reporter @FreeBeacon. DMs open. "On a jihad, publishing scoops that have left blood on the floor at Harvard, Columbia, Stanford, Duke"—Jill Abramson.
Emil Kirkegaard @KirkegaardEmil
45K Followers 959 Following #psychology #genomics #hbd #rstats #statistics #transhumanism #dataviz #openscience #psychometrics @OpenPsychJour
Vivek Subbiah, MD @VivekSubbiah
39K Followers 2K Following Chief, Early-Phase Drug Development|@SarahCannonDocs #Oncologist, #Phase1trials, #PrecisionMedicine. Tweets=My own.
Dennis Lal @LalDennis
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Cancer Genomics Conso... @CG_Consortium
2K Followers 3K Following The CGC represents clinical cytogeneticists, molecular geneticists, and molecular pathologists to promote best practices & education in clinical cancer genomics
Chris Stringer @ChrisStringer65
30K Followers 241 Following Tweets my own; likes/retweets do not necessarily signify agreement with content.
David Schmitt @PsychoSchmitt
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Charles Murray @charlesmurray
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48 Followers 28 Following Computational population genetics. Fulbright scholar @mpi_eva_leipzig. @stanford CS alum.
Dover Publications @doverpubs
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270 Followers 139 Following PhD in Biomedical Informatics @ Harvard Medical School (2024-) 🧬 Interested in statistical genetics
David Gokhman @David_Gokhman
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21K Followers 185 Following Chief Quant, Dir Analytics @_MathAcademy_ I do our algo-heavy infra: AI expert system, knowledge graph… ✍️serious upskilling 🔊"Sky-zack" 🪫wish I cd reply more
Na Cai @caina89
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Jacob Kimmel @jacobkimmel
8K Followers 3K Following Co-founder & President @NewLimit | Prev: PI @Calico, PhD @UCSF | Interested in aging, machine learning, genomics, the technology production function
The Institute for Fam... @FamStudies
11K Followers 989 Following Research on marriage, family life, and the welfare of children. Follow our writers: https://t.co/uufBc2lvKc ("Of Note" not an endorsement.)
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13K Followers 1K Following Geographer. Prof at Temple University. Author of 2 books. Elephants. Maps. Archaeofuturist Transportation.
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109 Followers 220 Following Statistical genetics grad student @UdeMontreal | OpenMTL events helper (link below) | Builder at heart
Matthew B. Jané @MatthewBJane
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Prof Richard Buggs @RJABuggs
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PALLADIUM Magazine @palladiummag
34K Followers 98 Following Exploring the future of governance and society since 2018. Become a member below to receive our latest print edition and invitations to our events ⬇️
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Epiphaneia @unes33501870
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Christopher John Lee @JunHongLi56447
100 Followers 1K Following I am a researcher engaged in psychometrics, Multi-omics, and Psychiatric Genetics. My hobby is studying the effects of accumulated mutation load. anti-ccp
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steve usdin @steveusdin1
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Hans Fredrik Sunde @hfsunde
732 Followers 670 Following Postdoc at @theCEFH, interested in assortative mating, behavioural genetics, and methodological issues. Not active here, find me on the other place!
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3K Followers 71 Following [email protected]:~$ whoami tech enby (agi/asi pronouns) (math ⊗ physic ⊗ comput).ist
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Richard Reinsch @Reinsch84
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Kristin Tsuo @KristinTsuo
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Commentary Recommends @CommentaryRec
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Jack Kosmicki @jakphd
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Yakup Ergün @dr_yakupergun
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Nikhil Milind @TheNikhilMilind
253 Followers 294 Following Genomics | Statistical Modeling | Complex Traits Doctoral Student at @StanfordBiosci
Anil Ori @anilpsori
491 Followers 1K Following Scientist | Population & medical genomics, health equity, and academia | Here for dialogue, community, and the subtweets ☕️ | Be someone's 🌺 whenever you can
Lili Anolik @LiliAnolik
5K Followers 1K Following Contributing Editor @vanityfair // Didion & Babitz OUT NOW!👇
Works in Progress @WorksInProgMag
20K Followers 27 Following Works in Progress is a magazine of new and underrated ideas to improve the world. Subscribe to our new print edition now. We are proud to be part of @Stripe.
Othram Inc. @OthramTech
7K Followers 35 Following Join our mission to revolutionize how forensic cases are solved, justice is served, and families are mended.
Raffaele Colombo @raffcolo
2K Followers 789 Following ADCs, targeted therapies, chemistry, biotech, pharma. Associate Director @ Zymeworks
Parker Rogers @parker_rog
790 Followers 335 Following Assistant Professor @KelleySchool @IndianaUniv studying innovation and health policy. Previously postdoc @nberpubs | @UCSDEcon PhD
Trevor Cousins @trevorcousins_
650 Followers 498 Following Computational Biologist interested in using algorithms to learn about human genetics.