Ziyuan Zhao @zhaoziyuan2000
PhD at @harvard. Studying cell organization in TB and cancer at @harvard_lab. Unconventional AI4bio. Boston, MA Joined May 2020-
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In two weeks, the 2025 Nobel Prizes will be announced. Based on looking at other pre-Nobel “predictor” prizes, I think that these 36 scientists are the most likely candidates:
Can we understand biology from "infinite" amounts of perturbation data ? - Only if we measure the relevant molecules. Perturbations and data scale 𝐜𝐚𝐧𝐧𝐨𝐭 compensate for missing the relevant molecules. 🧵
How do you use a virtual cell to do something actually useful? (2/3) In this second case study, we explore how our research at @NOETIK_ai suggests better inclusion criteria for a real-world, 2024 cancer clinical trial. Link below! As we mentioned in our last essay, the…
Rubisco is (arguably) the most abundant protein on Earth. (LPP surely comes close, right?) It’s an enzyme that fixes CO₂ into sugars during photosynthesis. Unfortunately, as most people learn in school, Rubisco is inefficient. Sometimes it confuses O₂ for CO₂ and wastes…
UniFORM: Towards Universal Immunofluorescence Normalization for Multiplex Tissue Imaging biorxiv.org/content/10.110…
Cancer is an evolutionary disease, but does knowing a cancer’s evolutionary past help predict its future? Out today in @Nature, we learnt the evolution of 2000 lymphoid cancers and found it was highly correlated with clinical outcomes! (1/7, link below)
High costs motivate efforts to predict spatial transcriptomics from H&E images w/ deep learning. In our recent preprint, we show that noise, sparsity & resolution in ST data impact performance, highlighting the importance of training data quality: biorxiv.org/content/10.110… 🧵1/n
In my line of work we call it lab meeting
People who are good at programming will use AI to take the jobs of those who are mediocre at it. So you should study CS iff you're going to be good at it.
Extract of gpt-5-thinking system prompt As always, there may be errors, but I have gotten the same thing twice with different prompting This is a different prompt than that used for gpt-5-main and more difficult to extract (you need thinking on) 1. Intro and sycophancy
In 1994, I went for my first sabbatical, at Max Planck Institute for Metals Research, in Stuttgart, Germany. My host, Manfred Rühle, let me alone. In the Institute Library, I discovered Gibbs’s paper on phases in a pure substance. What a revelation! docs.google.com/document/d/1iE…
Increasing evidence that innate immune pattern recognition receptors do not sense productive infections. DeRisi lab finds that RSV does not induce IFNs in productively infected cells. Only bystander/non-productively infected cells produce IFNs. journals.asm.org/doi/10.1128/mb…
When it comes to deep learning for protein engineering, there is strength in simplicity. In a Preview piece @CellCellPress, we highlight work from @CaixiaGaoLab on using fixed-backbone sequence design to engineer genome editors with improved function. 📄 authors.elsevier.com/a/1leKGL7PXuFlF
I'm now in my 10th year of teaching genetics to 1st year @harvardmed students in the classroom. Each year, I learn as much from them as they (hopefully) learn from me. Some things I've learned / appreciated: 🧵 [1/8]
I'm (slowly) writing the book I've been thinking about for the last 3+ years. Nothing official yet, but I'm hoping to write a deeply mechanistic and interactive, Bartosz Ciechanowski-style book about how a single E. coli cell works. It will cover DNA, transcription, signaling,…
🚨New paper 🚨 Can protein language models help us fight viral outbreaks? Not yet. Here’s why 🧵👇 1/12
Two recent papers used deep learning to either create, or discover, new antibiotics. I'll first look at the paper that made new antibiotics from scratch (and then maybe write another post about the discovery paper.) The crazy thing about this paper, in particular, is that they…
I built an iphone app: CTCAE 6 GO: a fast, clean reference for CTCAE v6/v5 toxicity grading based on recent NCI updates App is free; PRO= unlimited sharing, case saving, full search. 3 mo PRO free code in comments. Trainees, DM me for free PRO Grateful for feedback 🙏
Have you ever noticed that people dressed better in the past? Even in the summer, when it was scorching hot? Why is this? 🧵
1/ Our new preprint: Noise-driven morphogenesis independent of transcriptional regulatory programs. #DevBio #Morphogenesis #PatternFormation #GeneRegulation Details below…
Young Hwan Chang @QBI_Lab_OHSU
387 Followers 668 Following Quantitative BioImaging Lab, BME and CompBio, @OHSUKnight • Previously Postdoc EECS @UCBerkeley | PhD from ME @UCBerkeley | BS/MS from AE @kaistpr
Jiaqi Lu @jiaqilu2002
32 Followers 184 Following PhD student at Harvard | functional genomics + AIVC
Tanjina Kader 🎗️ @TanjinaKader
520 Followers 848 Following Post-doctoral Fellow, Laboratory of Systems Pharmacology (Santagata/Sorger Lab), Harvard Medical School | Previously Peter MacCallum Cancer Centre 🇦🇺
misha @ermakov_mikhail
142 Followers 744 Following PhD student @medunigraz / cancer research enthusiast Prev: visiting @harvard_lab
Young Hwan Chang @QBI_Lab_OHSU
387 Followers 668 Following Quantitative BioImaging Lab, BME and CompBio, @OHSUKnight • Previously Postdoc EECS @UCBerkeley | PhD from ME @UCBerkeley | BS/MS from AE @kaistpr
Jonathan Kagan @jkagan1
8K Followers 84 Following Scientist at Boston Children's Hospital, Professor of Pediatrics at Harvard Medical School, Husband, Father.
Jiaqi Lu @jiaqilu2002
32 Followers 184 Following PhD student at Harvard | functional genomics + AIVC
derek guy @dieworkwear
1.4M Followers 956 Following Menswear writer. Editor at @putthison. Bylines at The New York Times, The Financial Times, Politico, Esquire, and Mr. Porter
Silvi Rouskin @silvirouskin
9K Followers 664 Following Asst. Prof. at Harvard Medical School. #RNA biology#viruses #AI # https://t.co/Ihy7mZhjL5 @harvardmicro ; opinions are my own. https://t.co/9lMkSHvpn9
Hattie Chung @hattaca
2K Followers 1K Following assistant prof @Yale @YaleMed | aging, tissue homeostasis, predictive biology | @hattaca.bsky.social
Gabriele Berton @gabriberton
7K Followers 1K Following Postdoc @Amazon working on VLM - ex @CarnegieMellon @PoliTOnews @IITalk
Rohit Singh @rohitsingh8080
2K Followers 626 Following Computational biologist. Faculty @DukeU. Co-founder https://t.co/NPPgsZa9sa. Prev @MIT_CSAIL. Did quant investing for a while, before returning to research.
Patrick Schwab @schwabpa
7K Followers 2K Following ML for Drug Discovery and Health. Posts are personal opinions.
Ruslan Medzhitov @RMedzhitov
11K Followers 713 Following
Tanjina Kader 🎗️ @TanjinaKader
520 Followers 848 Following Post-doctoral Fellow, Laboratory of Systems Pharmacology (Santagata/Sorger Lab), Harvard Medical School | Previously Peter MacCallum Cancer Centre 🇦🇺
misha @ermakov_mikhail
142 Followers 744 Following PhD student @medunigraz / cancer research enthusiast Prev: visiting @harvard_lab
Eric and Wendy Schmid... @Schmidt_Center
819 Followers 147 Following We seek to understand the programs of life by creating a strong community at the interface of ML and biology. Join our mailing list: https://t.co/35Avp7DRvS
Alpenglow Biosciences @alpenglowbio
390 Followers 733 Following Accelerating drug development with AI-enabled 3D spatial biology
Arjun Raj @arjunrajlab
28K Followers 2K Following Just another LLM. Tweets do not necessarily reflect the views of people in my lab or even my own views last week. https://t.co/fZAnUCqd12
Peter Koo @pkoo562
2K Followers 849 Following Associate Professor @CSHL, advancing deep learning for genomics
Dr. Jean Fan @JEFworks
8K Followers 393 Following Associate prof @JHUBME. Doing #singlecell #spatialtranscriptomics #compbio #dataviz. Founder @cuSTEMized. Editor @PLOSCompBiol. Alum @HarvardDBMI @blairmagnet.
Sasha Gusev @SashaGusevPosts
20K Followers 3K Following Statistical geneticist | Associate Prof at @DanaFarber / @harvardmed / @DFCIPopSci | Blogging at https://t.co/4D7UObBNdd
Manolis Kellis @manoliskellis
29K Followers 4K Following Dissecting disease mechanism. Single-cell, Epigenomics, Regulatory Genomics, Disease Genetics, Brain, Cancer, Metabolism. @MIT Prof, @MIT_CSAIL, @BroadInstitute
Keyon Vafa @keyonV
5K Followers 826 Following Postdoctoral fellow at @Harvard_Data | Former computer science PhD with @Blei_Lab at @Columbia University | Researching AI + world models
Tim Stearns @StearnsLab
16K Followers 1K Following Professor and Dean at The Rockefeller University. Cell biologist. Believer in the power of science education.
Sri Kosuri @srikosuri
18K Followers 3K Following Cofounder & CEO, @octantbio ; BoD @Ginkgo ; Previously Associate Professor, @uclachem
Anshul Kundaje (anshu... @anshulkundaje
27K Followers 3K Following Federally funded academic research is the innovation engine of the US economy. Reform is welcome. Destruction will have long term consequences.
Mariam Aboian @MariamAboian
4K Followers 2K Following #Scientist #Neuroradiologist #NucMed #Dreamer: Inspired by #science & friends, goal=make the world more #welcoming & open doors to students from all walks
Jakob Nikolas Kather @jnkath
5K Followers 3K Following Professor of Medicine and Computer Science | Clinical AI at @medizin_TUD @tudresden_de @katherlab | Medical Oncology at @NCT_UCC_DD & @NCT_HD 💻🧬🇪🇺🌍
Jame Abraham, MD, FAC... @jamecancerdoc
12K Followers 2K Following Prof & Enterprise Chair Dept. of Heme & Oncology @ClevelandClinic @NRGonc Deputy Editor @ASCOPost & @JCOOP_ASCO Tweets mine. No act of #Kindness is ever wasted!
Anirban Sen Gupta @JishnuSenGupta
4K Followers 2K Following Wallace R. Persons Professor @CWRUBME. Bio-Inspired Engineering for Advanced Therapeutics, @Sen_Gupta_Lab, FAIMBE, FBSE, NAI Senior Member, Co-Founder @HaimaThr
Justin Lathia, PhD �... @JustinLathia
7K Followers 2K Following Lab studying cancer from a stem cell and cell-cell interaction perspective, #cancerstemcells, #glioblastoma, #GBM. Tweets are my own. @DrexelUniv @NIHOxCam alum
Vivek Subbiah, MD @VivekSubbiah
39K Followers 2K Following Chief, Early-Phase Drug Development|@SarahCannonDocs #Oncologist, #Phase1trials, #PrecisionMedicine. Tweets=My own.
Anirban Maitra @Aiims1742
31K Followers 3K Following Pancreatic cancer researcher, GI pathologist, husband, dad. Striving to improve the lives of patients with cancer. 🇺🇸 🇮🇳
RSNA @RSNA
71K Followers 2K Following The Radiological Society of North America is a nonprofit professional membership society committed to excellence in patient care through education & research.
Daniel E Spratt @DrSpratticus
11K Followers 519 Following The comments & viewpoints are my own and are not endorsed or necessarily representative of UH CMC, CWRU, NCCN, FDA, NCI, or NRG. They are my personal opinion.
Pranav Rajpurkar @pranavrajpurkar
26K Followers 807 Following Co-Founder a2z Radiology AI https://t.co/mdi996SFZy | Assistant Professor Harvard Lab: https://t.co/Z6tBGoluEG
Anant Madabhushi @anantm
4K Followers 1K Following Artificial Intelligence, Cancer imaging, Digital pathology, #radiomics, #pathomics, precision medicine. Tweets are mine.
Martin Weigert (mawei... @martweig
2K Followers 589 Following machine learning, image analysis, microscopy; Prof Comp Sci @tudresden_de & @Sca_DS.AI; Former EPFL, CSBD, MPI-CBG
Sam Gershman @gershbrain
17K Followers 60 Following Professor, Department of Psychology and Center for Brain Science, Harvard University
John Carroll @JohnCendpts
71K Followers 107 Following 47 yrs before the mast. Invented FierceBiotech, founded Endpoints News w/ 243,000 subs. Devoting time to the big showdown with Merkel cell carcinoma . We'll see
AdlungLab Systems Imm... @AdlungLab
779 Followers 226 Following May contain fat... "Still not lovin' disease" (https://t.co/E5HEwNuPR8) | "Come, give science a hug" (https://t.co/NKvoFbIN9y) | Tweets by π @lorenzadlung
Judith Agudo @JudithAgudo1
2K Followers 664 Following Immune evasion of stem cells and cancer stem cells. Mother of 3 boys. Tweets are my own.
Xu Zhou (周旭) @XuZhouLab
2K Followers 746 Following AP @BostonChildrens @harvardmed AM @broadinstitute inflammation, tissue biology, quant.&systems immunology #1stGen #ImmigrantScientists @xuzhoulab.bsky.social
Sven Dorkenwald @sdorkenw
2K Followers 171 Following Shanahan Fellow @ Allen Institute and University of Washington. Researcher @ Google Research
Diego del Alamo @DdelAlamo
5K Followers 499 Following Computational protein engineering & synthetic biochemistry Opinions my own https://t.co/m0Z0LCfSCt
Michael Oberst @MichaelOberst
2K Followers 987 Following Assistant Professor of CS at @JohnsHopkins, Part-time Visiting Scientist @AbridgeHQ. Previously: Postdoc at @CarnegieMellon. PhD from @MIT_CSAIL.
Jim Fan @DrJimFan
327K Followers 3K Following NVIDIA Director of Robotics & Distinguished Scientist. Co-Lead of GEAR lab. Solving Physical AGI, one motor at a time. Stanford Ph.D. OpenAI's 1st intern.
Monica Agrawal @MonicaNAgrawal
3K Followers 359 Following Asst prof at @DukeU. Co-founder at @LayerHealth. ML and NLP for healthcare. PhD @mit_csail, BS/MS @stanford. She/her.
Xiaole Shirley Liu @XShirleyLiu
10K Followers 68 Following Computational biologist specializing in data sciences of transcriptional and epigenetic gene regulation, CRISPR screens, and cancer Immunology
Tomasz Kosciolek @Tomasz_Lab
386 Followers 201 Following Structural and Functional Genomics group at @SanoScience in Kraków, PolandTrends for United States
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