Agalliu Lab @AgalliuLab
Laboratory of Dritan Agalliu, Ph.D. neuroimmunology / vascular biology / blood-brain barrier biology / neuroscience - account run by lab members columbiaagalliulab.org Columbia University Joined November 2019-
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Agalliu Lab retweeted
We identify a unique brain endothelial cell (BEC) type one interferon (IFN1) signature in human and mouse ischemic stroke tissue. We show that deletion of endothelial IFN1 receptor (Ifnar1) exacerbates post-stroke BBB disruption and expands angiogenic and immature BBB features .
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Agalliu Lab retweeted
Vascular normalization [stabilization of aberrant angiogenesis and restoration of blood-brain barrier (BBB)] is critical for reducing long-term sequelae after ischemic stroke. How immune and developmental signaling pathways coordinate these processes is poorly understood.
Agalliu Lab retweeted
Conversely, IFNβ administration immediately after stroke reduces acute BBB disruption. Activation of IFN1 signaling in mouse BECs in vitro promotes junctional stabilization and reduces VEGF signaling to enhance barrier properties, but suppress angiogenic features.
Agalliu Lab retweeted
am excited to share with everyone a new pre-print of the work of a very talented MSTP student Mary Claire Tuohy entitled “Endothelial Type I Interferon signaling modulates the vascular response to ischemic brain injury”. biorxiv.org/content/10.110…
Agalliu Lab retweeted
I am very happy to report that our manuscript describing the requirement of Rab7a to degrade select BBB junctional proteins during acute BBB breakdown after stroke is accepted at Acta Neuropathologica Communications! The final paper will be available soon biorxiv.org/content/10.110…
Agalliu Lab retweeted
Thank you to everyone who has supported my postdoc Ugur Akcan and his research to elucidate how PANDAS/PANS is triggered in the brain. We still need more help to reach our goal in order to support Ugur for an additional year while NIH funding is terminated. Thank you!! ♥️♥️
Agalliu Lab retweeted
@JasonSynaptic Thank you @JasonSynaptic. Unfortunately we will have to resort everything to keep the young scientist careers alive in the middle of this awful situation.
Agalliu Lab retweeted
As of today @Columbia has not received ANY of the terminated funding and many non-competitive renewal of federal grants. Therefore, last week the university starting laying off postdocs. If you care about PANDAS research please support my postdoc joinus.cuimc.columbia.edu/index.cfm?fuse…
We are extremely grateful to @PANDASPPN for their support of Dr. Ugur Akcan ( @occludens ) to continue his studies on the mechanisms by which RXRA affects immune responses in PANDAS/PANS after he lost his NIH fellowship. Thank you!!!!!
We are extremely grateful to @PANDASPPN for their support of Dr. Ugur Akcan ( @occludens ) to continue his studies on the mechanisms by which RXRA affects immune responses in PANDAS/PANS after he lost his NIH fellowship. Thank you!!!!!
Agalliu Lab retweeted
Finally, someone is reporting on how funding of new NIH grants is effectively frozen due to an administrative block 👇 Grants already submitted cannot be reviewed, and grants already reviewed with excellent scores cannot be funded. This is the opposite of "efficiency".
Finally, someone is reporting on how funding of new NIH grants is effectively frozen due to an administrative block 👇 Grants already submitted cannot be reviewed, and grants already reviewed with excellent scores cannot be funded. This is the opposite of "efficiency".
Agalliu Lab retweeted
Brain pericytes and perivascular fibroblasts are stromal progenitors with dual functions in cerebrovascular regeneration after stroke | Nature Neuroscience nature.com/articles/s4159…
Agalliu Lab retweeted
Extraordinary and chilling news out of Vanderbilt. Expect peer institutions to show higher yields on offers. At Hopkins @CMM_JHU , we will admit, but make fewer offers out of an abundance of caution. vanderbilthustler.com/2025/02/15/gra…
Agalliu Lab retweeted
The path to scientific discoveries is not easy and requires a lot of funding. If you are interested in us continuing our work to unravel the mechanisms by which Group A Strep trigger PANDAS/PANS in the brain please consider DONATING to the @AgalliuLab as a gift at the end of 2024
Lab brunch to celebrate the defenses of Connor + Mary Claire!! 🥳🙌🥳🥂
Congratulations to our favorite future double doctor Mary Claire on a spectacular defense today! You are truly a science star, and we wish you the very best on your return to the clinic!! 💫✨ #onedoctoratedown #onetogo
Congratulations to our very own Connor on his incredible defense!! We are so proud of you and very excited for what the future holds!! 😍😍🥳🥳#drconnorinthehouse
Agalliu Lab retweeted
Congratulations Connor @AgalliuLab on successfully defending your thesis!🎊🍾 All the best Dr. for your journey ahead!✨
Agalliu Lab retweeted
Join us @Roche's Institute of Human Biology (IHB) as a Scientific Group Leader! Lead innovative research in #HumanModelSystems such as #Organoids. We especially seek applications aligned to our commitment to diversity and inclusion. More go.roche.com/11jc8 #TeamIHB #pRED
Go @ConnorMonahan8 !!!!
Agalliu Lab retweeted
Looking forward to Connor’s dissertation defense. The @AgalliuLab will be there for support.
Looking forward to Connor’s dissertation defense. The @AgalliuLab will be there for support.
Dritan Agalliu @DAgalliu
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