Alec Cook @AlecCookPhysics
Physics PhD specializing in single-molecule biophysics. Studying the hybridization and strand displacement in DNA and RNA. Looking for work! PhD GA Tech BS UGA Joined October 2016-
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Using #CryoEM to find the structure of D-loops, formed when strands of DNA are exchanged during homologous recombination. elifesciences.org/articles/10840…
Theoretical models for tension-dependent DNA looping time, Wout Laeremans #Biophysics go.aps.org/41vuwYd
A major part of my PhD is out! 🎉 In this preprint, we introduce single-molecule flow cytometry (smFC), pushing detection sensitivity 10–80× beyond conventional flow cytometry. 1/n 👉biorxiv.org/content/10.110…
🚨Preprint alert🚨 We show experimentally that DNA minicircles adopt a favorite “inside-out” orientation depending on their sequence. Big thanks to Tony Lemos (@lemotony) for leading the work! biorxiv.org/content/10.110…
Engineered enzymes open up so many creative lab techniques. A group out of Sweden created an intentionally error-prone "sloppymerase" that introduces mismatches downstream of single-stranded breaks. SSBs can be located & quantified with high throughput! doi.org/10.1038/s41467…
Molecular evolution is just endlessly fascinating to me. A cool new @CellCellPress paper shows that the eukaryotic mismatch repair machinery has to compete with DNA-binding transcription factor proteins, increasing the mutation rate at TF binding sites. cell.com/cell/abstract/…
Here's a really cool new preprint out of @TheCrick. @LastEgoret al. used DNA fluctuations in an optical trap to estimate DNA intramolecular friction. Bending friction dominates at sub-kbp length scales, deviating from an ideal elastic rod. biorxiv.org/content/10.110…
Interesting paper out of Analytical Chemistry! Click chemistry (azide + DBCO) can be used to greatly accelerate toehold-mediated strand displacement in the presence of short toeholds or mismatches—essentially making the toehold-binding step irreversible. doi.org/10.1021/acs.an…
Please join us for another Lunch & Learn seminar tomorrow! This week, we have our first two speakers from the Sederberg Lab: Benyuan Liu and Eslam Abdelaleem. Lunch will be served at 12:00, followed by the talks at 12:30!
Please join us this Thursday (weather permitting!) for a talk from Indy Badvaram, our first PoLS speaker from the Banerjee Lab!
Today! See you all there at noon!
Today! See you all there at noon!
A new semester of Lunch & Learn seminars begins this Thursday! This week, we have a series of four speakers: Madison Hales, Chris Zuo, Prathyusha K.R., and Leo Wood. As always, lunch will be served in Howey N201 at noon Thursday, with talks starting at 12:30!
It's Thursday, and that means it's time for another Lunch & Learn seminar! This week's speaker is Emma Bingham from the Yunker Lab. Please join us in Howey N201 for lunch at 12:00, followed by a talk at 12:30!
Please join us today for another PoLS Lunch & Learn Seminar! This week's speaker is Tianyu Wang from the Goldman Lab. Lunch will be served in Howey N201 at 12:00, followed by a talk at 12:30. We hope to see you there!
Hello again, PoLS folks! Please join us for another Lunch & Learn seminar, this time hosted by @Mothyash from @SimonSponberg's Agile Systems Lab! Lunch will be served at 12:00 in Howey N201, followed by a talk from Yash at 12:30.
Trouble with too much hair? In our new paper, just out in @acsnano , we investigate what we call the "hairygami" effect: the entropy-induced bending of flexible DNA origami sheet at nanoscale when you functionalize it e.g. with ssDNA overhangs or attached proteins: 🧵1/5 ⬇️:
Today! Please join us for another Lunch & Learn seminar in Howey N201. Lunch will be served at noon, followed by a talk at 12:30 from Jianfeng Lin of the Goldman Lab discussing the effects of local and coupled body elasticity in overdamped undulatory locomotion.
This week's PoLS speaker will be Jianfeng Lin from the Goldman Lab. Please join us Thursday at 12:30 for another great talk!
Please join us today for another PoLS Lunch and Learn! Lunch will be served at noon in Howey N201, with a talk to follow at 12:30. This week's speaker is @ethanswold from the @BhamlaLab, who will tell us all about supra-resonant oscillations in insects.
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