Christian Porras @ChrisAPorras
MD/PhD Candidate 🩺 🧠 @IcahnMountSinai @LabRoussos New York, USA Joined April 2011-
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We are thrilled to share a preprint on human myeloid cells and AD. Collaboration with @panos_roussos @FullardJohn @ChrisAPorras @collin_spencer_ @MilosPjanic @PhilippWeiler7 and many others.
We are thrilled to share a preprint on human myeloid cells and AD. Collaboration with @panos_roussos @FullardJohn @ChrisAPorras @collin_spencer_ @MilosPjanic @PhilippWeiler7 and many others.
Check out dreamlet for single cell DE analysis!
Check out dreamlet for single cell DE analysis!
Puerto Ricans are among the most affected by #asthma in the world but there's little research. Our PRIMERO study is among the largest of its kind for a minority population, and we need your help. Please RT! #PuertoRicanStudy #2019SACNAS 1/3
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@ChrisAPorras @SACNAS Thanks so much for your support friend!!! 🙏🏽 😭
Nice view of our cover in @Nature!
This week in Nature: Mexican genomics – biobanks offer genetic insights into the diverse population of Mexico. Browse the full issue here: nature.com/nature/volumes…
Excited to share this first research output of my PhD! We uncover the intricate roles of microglia in Alzheimer's Disease and aging. We nominate cellular states, upstream regulators, and cell interactions involved in AD pathology for therapeutic targets
Plasticity of Human Microglia and Brain Perivascular Macrophages in Aging and Alzheimer's Disease medrxiv.org/cgi/content/sh… #medRxiv
Please Retweet! ** Dear all, it is an outstanding honor to share that I am on the ballot for the position of Student Board Member for the SACNAS Board of Directors. sacnas.org/board-election… 1/5
First time I get the cover of a magazine and it's in @Nature! Had this idea to illustrate the diversity captured by the MX Biobank across Mexico and brilliant designer @mauguz33 brought it to life inspired by indigenous Huichol art from near my home town. nature.com/nature/volumes…
Overall, our analysis prioritizes the GPNMB subtype as a potential therapeutic target to halt AD progression.
Via heritability analysis, we show the proliferation of the GPNMB subtype in AD is partially driven by higher polygenic risk for AD, and changes are observed even in samples that are neurotypical controls (free of AD pathology and w/o cognitive decline) with high polygenic score.
Via GRN analysis, we identify MITF as the upstream master transcription factor that regulates a significant fraction of genes, which are upregulated in AD. @collin_spencer_
We identify AD-associated microglia (ADAM) that highly expresses GPNMB. ADAM drives transcriptomic aberrations above and beyond the normal aging process.
We establish 13 distinct subtypes under 6 broad functional subclasses of human myeloid cells. Given the size and consistency of our annotation, we believe this taxonomy can serve as a reference atlas for future studies.
We generated the largest single-cell RNA sequencing datasets on human myeloid cells to date. To comprehensively understand the cellular changes in varying pathophysiology, we examined transcriptomes of 832,505 human myeloid cells/nuclei from the PFC of 1,607 unique brain donors.
Via CCI analysis, we show ADAM as the myeloid subtype with the highest number of dysregulated cell-cell interactions that are linked to AD and involve the APOE-SORL1-TREM2 signaling. @ChrisAPorras
We are thrilled to share a preprint on human myeloid cells and AD. Collaboration with @panos_roussos @FullardJohn @ChrisAPorras @collin_spencer_ @MilosPjanic @PhilippWeiler7 and many others.
Plasticity of Human Microglia and Brain Perivascular Macrophages in Aging and Alzheimer's Disease medrxiv.org/cgi/content/sh… #medRxiv
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Our new software dreamlet scales differential expression analysis for single cell data: doi.org/10.1101/2023.0… Checkout the R package: diseaseneurogenomics.github.io/dreamlet
Please check out the preprint of our lab's new single-cell software, Dreamlet, a faster, memory-efficient statistical model for large-scale single-cell differential expression analysis.
Our new software dreamlet scales differential expression analysis for single cell data: doi.org/10.1101/2023.0… Checkout the R package: diseaseneurogenomics.github.io/dreamlet
As the head of the multicultural strategic client segment for Swiss investment bank UBS, Melinda Hightower, MBA’07, is making financial advice more inclusive, one client at a time. ms.spr.ly/60015Pgvt
Medical students who sell their 'mentorship' to premeds for money should be reported for a lapse in professionalism.
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