Creative Biostructure @CreBiostructure
We specialize in offering solutions for academia and biotech/pharmaceutical industries in the fields of structural biology and membrane protein technologies. creative-biostructure.com Ramsey Road, Shirley, NY Joined November 2015-
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From construct design → host selection → Affinity/IEX/SEC → QC (DLS/CD/DSF/MS), great crystals start upstream. Our new guide shares solubility/stability fixes and scale-up tips to deliver crystal-ready protein—fast. 🔗 creative-biostructure.com/resource-optim… #StructuralBiology #DrugDiscovery
This study reveals how human SUMO E1 recruits its E2 partner UBC9 and transfers SUMO1 through large structural changes, uncovering key mechanisms that ensure specificity and fidelity in SUMOylation, an essential protein modification pathway. nature.com/articles/s4159…
SCXRD vs MicroED—what’s best for your crystal? • SCXRD: sub-Å precision, mature X-ray workflows • MicroED: nano/micro-crystals, minimal material, faster results 🔗 creative-biostructure.com/resource-scxrd… #Crystallography #SCXRD #MicroED #StructuralBiology #DrugDiscovery #MaterialsScience
Convergent evolution of proteins has been extensively studied at the levels of amino acid residues and local domain structures. Here, authors unveil a global structural convergence of protein complexes among fusion protein families in nature. nature.com/articles/s4146…
From snapshots to systems thinking: Integrative Structural Biology merges Cryo-EM/ET, X-ray, NMR, MS, SAXS, and MD/AI to deliver more accurate, dynamic models for #DrugDiscovery. Dive into workflows, case studies, and CRO use-cases in our new article. 🔗 creative-biostructure.com/resource-integ…
Comparison between structures of human, mouse and rat P2X7 receptors define ortholog-specific pharmacology and facilitated structure-based drug design of UB-MBX-46, an antagonist that selectively inhibits the human P2X7 receptor with sub-nanomolar potency. nature.com/articles/s4146…
MicroED vs. Cryo-EM SPA: • MicroED → atomic detail from tiny crystals • SPA → near-atomic maps of large complexes Full comparison: creative-biostructure.com/resource-micro… #MicroED #CryoEM #StructuralBiology
Here, the authors solve a series of cryo-electron microscopy structures that show how transfer RNAs (tRNAs) can guide the assembly of the multisubunit poxvirus RNA polymerase, uncovering a role of tRNA as an assembly chaperone. nature.com/articles/s4159…
Cryo-EM SPA turns noisy micrographs into near-atomic models—if your data pipeline delivers. Our new article covers motion correction, CTF, particle picking, 2D/3D classification, ab initio + refinement, heterogeneity, and tools like RELION/Scipion. creative-biostructure.com/resource-cryo-… #CryoEM
CRAF is one of three RAF-family kinases and is mutated in cancer and RASopathies. The authors report structural and mechanistic studies of CRAF/MEK1/14-3-3 complexes that explain distinct features of CRAF regulation. nature.com/articles/s4146…
AI + Cryo-EM = Faster, smarter, more accurate structural biology. 🔬🤖 From particle picking to 3D reconstruction, AI is transforming cryo-EM data analysis—accelerating discoveries in #DrugDiscovery & #MolecularBiology. 🔗 Read more: creative-biostructure.com/resource-artif… #CryoEM #AI
Using cryo-electron microscopy, the interactions of Sestrin2 and CASTOR1 with GATOR2 were resolved, revealing how mTORC1 activation is regulated and how nutrient availability triggers signalling for cellular growth. nature.com/articles/s4158…
From the protein-folding puzzle 🧩 to near-experimental precision 🎯 — AlphaFold has transformed #StructuralBiology. Discover how AlphaFold 1 → 2 → 3 revolutionized protein structure prediction & accelerates #DrugDiscovery. 🔗 Read more: creative-biostructure.com/evolution-of-a… #AlphaFold
CCR9 is chemokine receptor involved in gut inflammation and cancer. Here, the authors use AI-based modeling, protein engineering and pharmacological experiments to reveal the unusual anatomy of CCR9 activation by its endogenous chemokine agonist CCL25. nature.com/articles/s4146…
From snapshots to “molecular movies” 🎥 — Time-resolved #CryoEM captures fleeting molecular states with millisecond precision. See how it’s transforming drug discovery, GPCR research, and viral dynamics. 🔗 Read more: creative-biostructure.com/resource-time-… #MolecularDynamics #DrugDiscovery
The authors resolve high-resolution structures of complex multimeric RNA-only assemblies, redefining our understanding of non-coding RNA architecture and expanding the landscape of naturally evolved RNA nanostructures. nature.com/articles/s4159…
Cryo-EM captures proteins and viruses in atomic detail—no crystallization required. Explore its principles, tools, and transformative impact on structural biology and drug discovery. 👉creative-biostructure.com/cryo-em-techno… #CryoEM #DrugDiscovery #ElectronMicroscopy #CreativeBiostructure
The authors use several structural approaches to analyze the distribution of nucleosomes at the lamin–chromatin interface, test the impact of lamins on nucleosome density and identify a lamin A nucleosome-binding motif. nature.com/articles/s4159…
Cryo-EM reveals high-resolution protein structures—no crystallization needed. From membrane proteins to GPCRs and dynamic complexes, see how Cryo-EM supports modern drug discovery. 👉 creative-biostructure.com/resource-cryo-… #CryoEM #ProteinStructure #DrugDiscovery #CreativeBiostructure
The authors determined the cryo-EM structure of human GTPase-activating protein complex GATOR2 bound to CASTOR1 in the absence of arginine, providing insight into how CASTOR1 binds to GATOR2 to disinhibit GATOR1 when arginine levels are low. nature.com/articles/s4159…
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