Gitte Pedersen @DNABARCODE
RNA Platform for Next Generation Cures. By analyzing RNA we can detect disease, monitor health and design next generation cures genomicexpression.com Boston, MA Joined July 2009-
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Director of the NIH is very clear at the 8:04 mark of this clip regarding the likely cause of Long COVID: "We see evidence of persistent live virus in humans in various tissue reservoirs, including surrounding nerves, the brain, the GI tract, to the lung." medpagetoday.com/opinion/faustf…
My annual reflection on how to become unstoppable in #2024 - enjoy fsmisc.s3.ca-central-1.amazonaws.com/2023+AR.pdf youtube.com/watch?v=TzAN6e…
This paper is dense and deserves a break down. Here you go: There are increasing reports suggesting that a COVID-19 infection might either start or speed up neurodegenerative diseases like Alzheimer's disease (AD) and Creutzfeldt-Jakob disease (CJD). These diseases (and…
This paper is dense and deserves a break down. Here you go: There are increasing reports suggesting that a COVID-19 infection might either start or speed up neurodegenerative diseases like Alzheimer's disease (AD) and Creutzfeldt-Jakob disease (CJD). These diseases (and…
They were sentenced for up to 10 years for violating anti-abortion laws. Some say their pregnancy was a result of rape. Rwanda has now liberalized its #abortion laws and pardoned hundreds of the women. npr.org/sections/goats…
I'm in my 27th year of being a doctor and I still have never used Organic Chemistry.
I just can’t - @LibbyMbc you will be missed 💙#BCSM #ThisIsMBC I hope the #KarensOfCancer have MANY sleepless nights. ca.style.yahoo.com/calgary-mom-li…
THIS IS GOING VIRAL SO I WANTED TO SHARE IT HERE TOO: A bit from my past: My first job after getting my PhD was working as a therapist for people from low socioeconomic backgrounds. Almost all of them were diagnosed with depression, GAD, bipolar, or BPD. Most were highly…
“The U.S. is seeing a significant rise in COVID-19 cases & hospitalizations… That marked an 18.8% jump from the week before, and a staggering 86.9% increase over the past month.” cbsnews.com/news/covid-hos…
I get irritated by people who hoard data or think that they can't share things. If I ever have to choose, I always prefer to be too open rather than less open. The risks are relatively small and the upside is huge."
6. Mind the Incentives. "We are quite careful about incentives because it can drive the wrong behaviour. It's easy for people to start gaming whatever they're given as a target, and scientists are brilliant at doing that!
The rewards for R&D come from good quality work, good kills, inventive things, innovative things, demonstrated proof of mechanism, demonstrated proof of concept, diagnostic strategies, launches, and phase III investment decisions.
Failing early is important because it means you haven’t spent too much money and you don't just keep on. Before, we were very good at finding ways of getting to the next hurdle just for the sake of getting the next hurdle, because that’s what we were being measured on..."
3. Reward your Scientists for Killing Hypotheses. "Are your scientists asking killer questions to try, not just to validate, but *invalidate* your hypothesis? We celebrate good kills every day. We are passionate about it!
Right Commercial Why would anyone want to take or prescribe the medicine and why would anyone want to reimburse it?
Right Target • How well do you understand the biology of the target? • How well do you understand the disease pathophysiology, how it connects/relates to path you’re trying to modulate? • What genetic validation do you have in pre-clinical animal models or in human genetics?
Right Patient Find the patient population in which your medicine is most likely to work, because if It doesn't work in that patient population, it's not going to work on a broader patient population.
Right Safety Establish safety as far as possible in humanised systems before initiating clinical trials.
Right Tissue When you have a molecule, whether it’s a monoclonal antibody, a small molecule, or whatever the drug modality, demonstrate first of all in the preclinical models that you can engage the target and understand your PK/PD relationships.
He 5X'ed AstraZeneca's productivity from pre-clinical to phase III completion and transformed the company's R&D strategy, culture and approach to innovation. I spent hours researching Mene Pangalos. 10 key principles from his leadership playbook:
2. The 5R Framework. "Based on the data that we analysed, we found five things that would improve the probability of running a successful programme. The 5Rs may seem pretty obvious, pretty intuitive, yet actually quite difficult to execute on consistently."
C. Michael Gibson MD @CMichaelGibson
436K Followers 374K Following Non-Profit Founder/Leader | ❤️ Doc | Artist Scientist Educator | News Anchor https://t.co/7OIKCgMVAT | RT ≠ endorse | Disclaimer: https://t.co/bwmE2O3U5WBeth Frates MD @BethFratesMD
136K Followers 51K Following Pioneer in #lifestylemedicine, President @ACLifeMed, Author, Speaker, Coach, Received Teaching Accolades @harvardmed + @HarvardExt, Alum @Harvard + @StanfordMedThanks Cancer! @ThanksCancer
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93 Followers 485 Following I’m from Brooklyn New York in USA. but some of my workers are also from.C. Michael Gibson MD @CMichaelGibson
436K Followers 374K Following Non-Profit Founder/Leader | ❤️ Doc | Artist Scientist Educator | News Anchor https://t.co/7OIKCgMVAT | RT ≠ endorse | Disclaimer: https://t.co/bwmE2O3U5WBeth Frates MD @BethFratesMD
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18K Followers 5K Following Incoming Family Medicine Resident Physician @thenosm 🩺 MSc in Health Promotion @westernu 😷 Founder of @C19TestFinders 🧪 Proud Mother & Wife 👨👩👧👦David Christopher �.. @MLS_Dave
53K Followers 18K Following #FreePalestine #DoNoHarm #CancerAwareness #EndTheDuopoly We only have one planet 🌍🐋🐅🦏🦋🌳 🚫 War 🚫 HateBrenner Lab @Brenner_Lab
859 Followers 263 Following Dirk Brenner's research group in Luxembourg @LIH_Luxembourg and @uni_lu. We study #immunology, #immunometabolism in inflammation and cancer.I put all of the letters that my mom wrote me in a big binder. then, I added the cards that she got me. there’s still more to add, since I want to put the thst cards I got her in there too❤️
Director of the NIH is very clear at the 8:04 mark of this clip regarding the likely cause of Long COVID: "We see evidence of persistent live virus in humans in various tissue reservoirs, including surrounding nerves, the brain, the GI tract, to the lung." medpagetoday.com/opinion/faustf…
Did not Match, Did not SOAP, but I Scrambled into a Position in the Internal Medicine Program of Cleveland Clinic Florida! It Takes a Village that believes in you and your dreams! Thank you! If you can dream it, work hard, be consistent, persevere and you will achieve it!
My med student just asked if NK cells are a type of T cell!!! 😭😭💔💔 like a dagger through my heart.
StatCan just dropped a bombshell report on LC. This is the most important figure. It highlights that the risk of long term symptoms is cumulative, it increases with increasing number of infections. By 3+ infections, 38% report long term symptoms — that’s 1 in every 2.6 people. 🤯
Oh my goodness. Look at the words I missed in this thread. Look. This is the neurological damage SARS2 does. I am so sorry. I tried to make a coherent thread. I failed. Protect the children. I am begging you.
This paper is dense and deserves a break down. Here you go: There are increasing reports suggesting that a COVID-19 infection might either start or speed up neurodegenerative diseases like Alzheimer's disease (AD) and Creutzfeldt-Jakob disease (CJD). These diseases (and…
BRAIN and COVID ! "SARS-CoV-2 Spike amyloid fibrils specifically and selectively accelerates amyloid fibril formation of human prion protein and the amyloid β peptide" biorxiv.org/content/10.110…
Well it finally happened. Not to me but to my parents. They both got their Paxlovid prescriptions but their different experiences showed how YMMV depending on your health care provider. First shout out to the good folks at Kaiser Permanente. KP's system worked smoothly and well
June 26, 2009 I was 37 this is my ride, it was the best I could afford. A $3k S10 parked in front of the house that was about to be foreclosed on. No money, wanted to take my kids on a trip but couldn’t afford it. Bought a tent at a yard sale, threw kids sleeping bags in…
They were sentenced for up to 10 years for violating anti-abortion laws. Some say their pregnancy was a result of rape. Rwanda has now liberalized its #abortion laws and pardoned hundreds of the women. npr.org/sections/goats…
I just can’t - @LibbyMbc you will be missed 💙#BCSM #ThisIsMBC I hope the #KarensOfCancer have MANY sleepless nights. ca.style.yahoo.com/calgary-mom-li…
THIS IS GOING VIRAL SO I WANTED TO SHARE IT HERE TOO: A bit from my past: My first job after getting my PhD was working as a therapist for people from low socioeconomic backgrounds. Almost all of them were diagnosed with depression, GAD, bipolar, or BPD. Most were highly…
Usually keeping things professional around here but my heart is too full to contain it all: Please join me in welcoming the two newest members of Grünwald Lab 🌻🌻 Sorry to miss you all at conference season this year but it's for the best possible reasons... 🤓 #HappyNerd
Man, tough comments in this one. Let me offer a counter example A wife, ( my mother) laying aside her husband & best friend ( my dad) as their wedding song plays ( always and forever) gently comforting him as he slips into the afterlife The most human moment I’ve ever…
“The U.S. is seeing a significant rise in COVID-19 cases & hospitalizations… That marked an 18.8% jump from the week before, and a staggering 86.9% increase over the past month.” cbsnews.com/news/covid-hos…
I get irritated by people who hoard data or think that they can't share things. If I ever have to choose, I always prefer to be too open rather than less open. The risks are relatively small and the upside is huge."
8. Don't Keep your Ideas Top-Secret. "We were incredibly closed. We didn't want to share anything. Everything was proprietary. And to change that culture we had to do it in baby chunks... you chip away, you chip away, until eventually, people get comfortable.
The rewards for R&D come from good quality work, good kills, inventive things, innovative things, demonstrated proof of mechanism, demonstrated proof of concept, diagnostic strategies, launches, and phase III investment decisions.
6. Mind the Incentives. "We are quite careful about incentives because it can drive the wrong behaviour. It's easy for people to start gaming whatever they're given as a target, and scientists are brilliant at doing that!