Extracellular Matrix News @ExtracellMatrix
An online resource for the extracellular matrix and tissue engineering research community. Part of the @STEMCELLTech Science News service. extracellularmatrixnews.com Joined June 2010-
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Epigenetic changes, including DNA methylation and histone modification, can alter the normal immune and stromal cells in the #TME. This may enhance the effect of cancer driver mutations, report Drs. @hari_E_iyer16 and Ashani Weeraratna. 🔗 go.nature.com/42lxkr4
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📢 A novel strategy integrating collagen sequence optimization and microbial prolyl-4-hydroxylase screening was developed to enable efficient production of triple-helical rhCol in Komagataella phaffii. 🔗 bit.ly/4nA1pM7
👇 Check out the signaling pathway that promotes #ECM degradation in primary human hepatic stellate cells, which is dependent on the activation of protein kinase Cα and the induction of matrix metalloproteinase 1! @UCSF @ScienceTM | bit.ly/4p6ZBM1
🧠 Researchers at @CCLRI identified TBK1 as a critical signaling molecule enriched and activated in tumor-associated macrophages of BCBM tumors, playing an indispensable role in BCBM development and metastatic outgrowth in the brain. @PNASNews | bit.ly/4g4ZPiH
Only in @CR_AACR! 📚 @mcgillu's Yu Gu and Dr. William J. Muller review the role of #osteopontin in non-tumor cells in the context of solid cancers and the associated phenotypic and mechanistic insights. Read it here: bit.ly/4n8dk3d
Dr. Sabine Werner and Michael Cangkrama show that different cancer cells transfer mitochondria to fibroblasts in cocultures and xenograft tumors, thereby inducing protumorigenic #CAF features. 🔗: go.nature.com/4mHTDzF 📰: bit.ly/46erTN1
Let's talk about #TAMS. 💬 This review synthesizes tumor-associated macrophage (TAMs) biology and immune crosstalk, providing a foundation for novel oncology strategies aimed at reprogramming TAMs to overcome treatment resistance. 🔗 go.nature.com/469I3ax
Hydrogels, a class of water-swollen networks with #ECM-mimic characteristics, have served as promising biomaterials for guiding the immune system in biological milieus. Read more about therapeutic #hydrogels used for immunomodulatory applications. 👇 bit.ly/4lQgXdc
🧠 Dr. Timothy Kennedy and colleagues from @mcgillu propose that synthetic synaptogenic extracellular matrices that resist proteolysis could be used to engineer electrodes with enhanced neural biocompatibility. 💡 Check it out in @acsnano: bit.ly/4lRzPbI
Drs. Tsukasa Kadota and Tien Peng summarize the role of #fibroblasts as a critical orchestrator of lineage plasticity that blurs compartmental identities to initiate proper repair or disease. 💡 Read the review: bit.ly/479tAfR
A new week means a new review! 📚 Learn about the molecular events through which #ECM mechanical properties, such as stiffness, and viscoelasticity, regulate #Treg identity and functionality. 👉 bit.ly/41Grn8b
💡 Researchers emphasized the importance of glutamine metabolism inhibition in suppressing tumor growth and disrupting cancer-associated #fibroblast-mediated crosstalk. 🔗 bit.ly/3JkGzBw
🤰 Drs. Samuel Ojosnegros, Anna Seriola, and Amélie Godeau and team at @IBECBarcelona demonstrated that embryos apply forces remodeling the matrix with species-specific displacement amplitudes and distinct radial patterns! @cddpress | bit.ly/4fNIvPa
📖 Dr. Ronen Sumagin's lab (@SumaginLab) at @NUFeinbergMed discusses the roles of MMPs in the maintenance of intestinal homeostasis and their contributions to imbalanced immune responses, epithelial integrity, and wound healing in #IBD. @jlb_journal | bit.ly/45Ym5XP
🤰 Scientists at @_BIST show that embryos apply forces remodeling the matrix with species-specific displacement amplitudes and distinct radial patterns. Check it out! 👉 @ScienceAdvances | bit.ly/4fNIvPa
🧫 Investigators demonstrated the role and mechanism of a subpopulation of Kupffer cells, the liver resident macrophages, in mediating tumoral induction of NETs and liver metastasis. 👉 @CellDiscovery | go.nature.com/3JCk4b2
New research out of @CAS__Science reports the role and mechanism of a subpopulation of Kupffer cells, the liver resident macrophages, in mediating tumoral induction of NETs and liver metastasis. 💡 Give it a read: go.nature.com/3JCk4b2
Keith Brennan and Andrew Gilmore led this study providing a mechanistic link between increased #ECM stiffness and the genomic damage required for breast cancer initiation. 🧬 More in @SciReports: go.nature.com/41CwF4g
Let's talk about #neutrophils. 💬 @sjtu1896 scientists review the development and diversity of neutrophils under both physiological and pathological conditions, with a particular focus on their roles in cancer. 💡 bit.ly/4fGVvpI
Scientists identify a subset of #PDAC cells with low L1CAM expression that actively influence collagen deposition and remodeling, as evidenced by the upregulation of COL17A1 and matrix metalloproteinase 2, both associated with poor prognosis. go.nature.com/45thXxP
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