GWAS_lit @GWAS_lit
Pre-publication manuscripts for genome-wide association studies. By @wpgilks Also see @genomic_pred and @Mendelian_lit #GWAS #genetics #genomics #medicine sites.google.com/view/williamgi… East Sussex, England Joined July 2015-
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A model for co-occurrent assortative mating and vertical cultural transmission and its impact on measures of genetic associations biorxiv.org/content/10.110…
isGWAS: ultra-high-throughput, scalable and equitable inference of genetic associations with disease biorxiv.org/content/10.110…
GxE PRS: Genotype-environment interaction in polygenic risk score models for quantitative and binary traits biorxiv.org/content/10.110…
Subset scanning for multi-trait analysis using GWAS summary statistics medrxiv.org/content/10.110…
Genome-wide analyses reveal widespread genetic overlap between neurological and psychiatric disorders and a convergence of biological associations related to the brain medrxiv.org/content/10.110…
Common- and rare-variant genetic architecture of heart failure across the allele frequency spectrum medrxiv.org/content/10.110…
Novel genomic loci and pathways influence patterns of structural covariance in the human brain medrxiv.org/content/10.110…
PA-FGRS is a novel estimator of pedigree-based genetic liability that complements genotype-based inferences into the genetic architecture of major depressive disorder medrxiv.org/content/10.110…
Estimation of indirect genetic effects and heritability under assortative mating biorxiv.org/content/10.110…
Fine-mapping across diverse ancestries drives the discovery of putative causal variants underlying human complex traits and diseases medrxiv.org/content/10.110…
Phenotypic and Genetic Characteristics of Retinal Vascular Parameters and their Association with Diseases medrxiv.org/content/10.110…
Polygenic risk score analysis reveals shared genetic burden between epilepsy and psychiatric comorbidities medrxiv.org/content/10.110…
Characterizing personalized effects of family information on disease risk using graph representation learning arxiv.org/abs/2304.05010
Joint models reveal genetic architecture of transitions between pubertal stages and their association with BMI in a Latino population medrxiv.org/content/10.110…
Genome-wide Association Study of Long COVID medrxiv.org/content/10.110…
Diversity and Scale: Genetic Architecture of 2,068 Traits in the VA Million Veteran Program medrxiv.org/content/10.110…
Polygenic risk score prediction accuracy convergence biorxiv.org/content/10.110…
Rapid and accurate multi-phenotype imputation for millions of individuals biorxiv.org/content/10.110…
Understanding the genetic complexity of puberty timing across the allele frequency spectrum medrxiv.org/content/10.110…
Improved Type 2 Diabetes Risk Stratification in the Qatar Biobank Cohort by Ensemble Learning Classifier Incorporating Multi-Trait, Population-Specific, Polygenic Risk Scores medrxiv.org/content/10.110…
Veera Rajagopal @doctorveera
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52K Followers 323 Following The American Society of Human Genetics (ASHG) is the world's largest professional membership organization for human genetics & genomics specialists.MR_lit @Mendelian_lit
2K Followers 58 Following Manuscript alert for genetic studies using Mendelian Randomisation. Sources: Pubmed, Biorxiv & Arxiv By @wpgilks Also see @gwas_lit and @genomic_predGWAS Catalog @GWASCatalog
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24 Followers 1K FollowingPhenotypic and Genetic Characteristics of Retinal Vascular Parameters and their Association with Diseases medrxiv.org/content/10.110…
@HKUniversity The mr_pivw function implements the penalized IVW method, described here: pubmed.ncbi.nlm.nih.gov/35942938/. This is an extension of the mr_divw method to account for weak IVs and winner's curse bias.
This week's Virus forecast where we look at forecast Covid, FLU, RSV and the over all influenza like Illness levels expected in your community using data from @HubbubWorld. #MaskUp Weekly Virus Forecast Watching Some New Concerning Areas youtu.be/xC_QW5x7VBU via @YouTube
Last week, we were sad to hear that Professor Ian Mackay had passed away. Mac was a quantitative geneticist of international standing and worked for NIAB between 2005 and 2017. We send our deepest condolences to his family and friends ➡️ ow.ly/rl0950ORscX
New Nature paper provides evidence that science has become less innovative since the 1950s. The authors suggest reversing the trend by: 1. reading widely, 2. focusing less on quantity of papers, & more on research quality, 3. taking year-long sabbaticals. nature.com/articles/s4158…
Ten random useful things in R that you might not know about by @dr_keithmcnulty in @TDataScience towardsdatascience.com/ten-random-use… #rstats
The world would be a slightly better place if we would move away from false dichotomy between statistics and machine learning jamanetwork.com/journals/jamap…
NEWS!! Changes in our web search interface are coming! Faster and easier to find #SumStats Would you like to HELP us? (1) Test it bit.ly/44P9Vhm (2) Send us your feedback to [email protected] or GitHub bit.ly/42KmzfO More on bit.ly/41XCAOO
Map of @github have arrived. Hope you enjoy it: anvaka.github.io/map-of-github/
PGSbuilder: An end-to-end platform for human genome association analysis and polygenic risk score predictions biorxiv.org/content/10.110…
We’re excited to announce that our analysis of genetic dominance in the UK Biobank genotype data is out in @ScienceMagazine (science.org/doi/10.1126/sc…) (1/12)
Rebuilding my #rstats website using #quartoPub, one of things I've most enjoyed reworking is my "About me" #dataviz. But it needed to be zoomable... Try to figure out the CSS on my own? 🫠 No! Quarto Lightbox extension to the rescue! github.com/quarto-ext/lig…
6. Male Testosterone Levels Plummeting: Some studies are pointing towards the following in men: 1. Testosterone levels dropped 20% in the last 20 years. 2. Sperm counts have plummeted by 59% from 1973. So few conversations about why this is happening.
Why has the media become more negative? "Blended study of 105,000 headlines and 370 million impressions concludes "each additional negative word [in a headline] increased the click-through rate by 2.3%" H/T @DKThomp
6) Another comprehensive review that focuses on one specific phenotype is one by @PhilipAlz et al. where the main developments in the field of Alzheimer's disease are discussed, including its genetics. link: ncbi.nlm.nih.gov/pmc/articles/P…
Just got a recent intel macbook due to the cat destroying the previous laptop. I can really see why people moan about the keyboard. It works well but really not nice to write on at all. Have they changed the keyboard in the new M2 macbooks? I hope so.
/1 Want to know the secret to optimizing your SQL queries? Understanding the execution order is key.
Deep learning based phenotyping of medical images improves power for gene discovery of complex disease medrxiv.org/content/10.110…