Gabriel Filsinger @GabrielFilsing1
Post-Doc Michael Fischbach's lab @mfgrp @Stanford Ph.D. @geochurch lab, @Harvard Systems Biology Joined April 2020-
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I'm biased, but this paper (and the accompanying mega-thread) could be one of the most important things you read. Time is the scarcest resource, so it's essential to prioritize the best possible problems to work on. Choose Good Quests. Pick Good Problems.
I'm biased, but this paper (and the accompanying mega-thread) could be one of the most important things you read. Time is the scarcest resource, so it's essential to prioritize the best possible problems to work on. Choose Good Quests. Pick Good Problems.
Writing converts your ideas from vague to bad. But once they're written down you can at least see and fix the badness.
We're looking for a research assistant to help develop technology for in-vivo editing in immune cells. Non-obvious and interesting work in a hot field. Please forward to anyone you think might be interested! careersearch.stanford.edu/jobs/life-scie…
Great conceptual work taking a peek inside the LLM black box.
Great conceptual work taking a peek inside the LLM black box.
Today we report a detailed map of interactions between the immune system and the gut microbiome. @MicrobiomeTcell led the charge w/ help from Aishan Zhao and Kat Atabakhsh. @Nature 1/40 nature.com/articles/s4158…
Some of the best people I know are expanding their team with exciting roles. Prioritize taking a look at this/sharing if you’re interesting in cutting edge therapeutics development.
Some of the best people I know are expanding their team with exciting roles. Prioritize taking a look at this/sharing if you’re interesting in cutting edge therapeutics development.
The IL-18 armored CAR-T data from @carlhjune's group at ASH this year is remarkable (ash.confex.com/ash/2022/webpr…). 100% ORR so far, 7/8 patients had relapsed on a prior CAR-T product. IL-18 baby!!!
To be clear I love hard work, I do well with chaos, but I like doing it with people I like, for a mission I care about and ideally with significant upside potential (financial or otherwise) to balance downside risk.
@natfriedman "All Fallen Empires begin the game in Sleeping status. Despite their complete development and immense power, the Fallen Empires will remain passive, staying within their borders and taking no action unless provoked." haha
Turns out everything is a matrix multiplication from computer graphics to training neural networks :) Our latest front cover @Nature paper on #AlphaTensor here: dpmd.ai/nature-alpha-t…
Today we report a new model system for the gut microbiome: hCom2, a defined community of 119 strains. @AliceCheng107 led the charge, with major contributions from Po-Yi Ho, @DrChilennial, and @SunitJain. Co-led by my longtime collaborator KC Huang. 1/22 cell.com/cell/fulltext/…
Big news at @ManifoldBio: We closed our Series A! Our vision for the power of in vivo biologics design is coming to life and it's all thanks to our brilliant team. More here and below: manifold.bio/blog/in-vivo-b…
Slow Boring guest post today 👀 slowboring.com/p/we-could-hav…
Happy to share the first manuscript coming out of our laboratory! Here, we investigated the adverse effects associated with in vivo reprogramming and developed a new mouse strain that allows long-term induction of in vivo reprogramming. biorxiv.org/content/10.110…
I had a blast at #SEED2022! Was wonderful to see some old friends and make new ones. It’s amazing to see how far the field has come in just a few years! Anyway, here are my full notes for the conference. I got every talk. docs.google.com/document/d/13r…
We're looking for an insanely great computational biologist (or hybrid!) to join us at @ManifoldBio (manifold.bio/careers) In short, this is not your typical computational biologist role. Here’s why: [1/7]
My lab looking for RAs/postdocs/scientists to help us engineer molecular technology for applications in human disease. We try to solve big problems and have fun doing it. Here's the lab last week on a trip to Hawaii. shipmanlab.org/open-positions Please share and spread the word.
Crystal Patel @CrystalPat80604
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13K Followers 824 Following I write a concise small/micro cap focused newsletter for (mostly) professional investors. Value, GARP, special situations. Join my list below:marginofdanger @marginofdanger
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8K Followers 922 Following Long / Short equities. Value investor. Istanbul https://t.co/vNBoJqo6JiNo Called Strikes Inv.. @NCSI_SA
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2K Followers 114 Following I'd rather play suckers than beat the best—trying to find the right table https://t.co/MOU1CdjJVOUSGS ShakeAlert @USGS_ShakeAlert
45K Followers 140 Following Keep up-to-date on ShakeAlert System news, updates, and other information. Tweets and "likes" are not endorsements.EarthquakePrediction @Quakeprediction
61K Followers 5 Following Earthquake prediction California, Alaska, Japan, Greece and Italy. Earthquake forecasts are based on research from (2005 to 2024) [email protected]Andrew Côté @Andercot
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11K Followers 1K Following Lab of Michael Elowitz at Caltech. Synthetic biology and systems biologyEric Schmidt @ericschmidt
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13K Followers 18 Following We need a new philosophy of progress for the 21st century. Subscribe: https://t.co/72IjFgDCwK Support: https://t.co/xM6IPiFSa7Jared Friedman @snowmaker
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47K Followers 40 Following * Math & art. Product Manager. Demoscener. * Created Quill, Shadertoy, Pixar's Wondermoss, Memix, ... * Videos: https://t.co/r50AVR0ITo * Tutos: https://t.co/MVjsGVRH5sAlex Telford @Atelfo
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6K Followers 0 Following The Steve Jobs Archive is the authoritative home for Steve’s story and a resource for new generations eager to make their own mark.It was a delight hosting such an engaged and enthusiastic 5050 cohort today! Excited to see all the new startups and breakthroughs that will come from this bright crew. P.S. we're hiring :)
Very inspiring for this cohort of 5050 to see a former 5050 whose startup is now off to the races. @nikitakhlystov epically holding up a bag of recycled polyester monomer made via @huminly's enzymatic recycling of old clothes.
The buzz of a new 5050 cohort kicking off is unbeatable
Zuck saw @TrentonBricken on the pod and stole his whole look
I ask @TrentonBricken how exactly all his interpretability research is supposed to tell us whether GPT-7 is a crazy ass paper-clipper or not: Trenton: "You have this alien brain and you have access to everything in it, and you can just ablate however much of it you want.…
Don’t sleep on the STING pathway!
New frontiers in the cGAS-STING intracellular DNA-sensing pathway dlvr.it/T5SFhn
A sneak peek of what's coming...
Manifold Bio is thrilled to announce that we'll be presenting a poster at #AANAM! Swing by and catch Co-Founder @ShaneLofgren in action as he shares the latest updates on our brain shuttling work enabled by our in vivo multiplexing platform . #AANmember #AANmember #Neuroscience
Not everyone who dies gets to come back and tell their story, but thankfully Freddy did. A reminder to hold the people you love a little closer tonight, that medicine and health are the greatest gifts, and that at the end of the day, we're all patients. jamanetwork.com/journals/jaman…
We were talking about bad names for a potential new dog. 15 yo suggested "Help."
and I had many of the same questions as @MartinBJensen in this thread, so would love to reopen the discussion :) x.com/MartinBJensen/…
I'm struggling to wrap my head around the new Weissman lab myHSC depletion paper: nature.com/articles/s4158… The first authors don't seem to be on twitter but hoping I can crowdsource a fun discussion. @dbgoodman @ImmunoFever @Jeff_Mold @Satpathology @CalebLareau...
Restored B & T cell populations & improved response to viral infection in aged mice via depletion of a dysregulated stem cell population Very cool proof of concept from Irv Weissman's lab! (s/o @MorrealeBrian for assisting w this video!)
How to pick a problem. Today in @CellCellPress. 1/53 cell.com/cell/fulltext/…
I am inspired by founders and their ability to envision and build the future. But building in Biotech is hard. Things never go to exactly to plan. As a founder, I dreamt of an environment where founders could get the support they need from investors and experts while maintaining…
We are very grateful for the support of Northpond Ventures—and for the continuous support of the Wyss Institute. We can’t wait to push forward the frontier of protein therapies with non-standard amino acids!
We're excited to announce that AminoX is the latest tech at the Wyss to be supported by @npv_vc through our alliance. AminoX is making it easier and cheaper to manufacture protein drugs with non-standard amino acids. wyss.harvard.edu/news/wyss-inst…
And to self-plug a bit, here's my reminder that higher education in the humanities is both a public good and also a national security imperative: foreignpolicy.com/2024/03/10/the…
Yesterday I had another smooth end to end ride in FSD around SF. It's really working. At some point Tesla will flip the switch and they'll have a massive robotaxi fleet
Unboxed my bioluminescent plants 😳🫣 #lightbio
It was the honor of a lifetime to work with @Geneticdesigner and the Voigt lab. I'm now devoting full effort to my work at @AsimovPress. We are expanding our publishing efforts significantly, and I'll share more about that soon.
How @_sholtodouglas got scouted by Google DeepMind: “Every night from 10 PM till 2 AM, I would do my own research. @jekbradbury saw some of my questions online and was like, ‘I thought I knew all the people in the world who were asking these questions. Who on Earth are you?’”
A good example is @_sholtodouglas at @GoogleDeepMind. He's quiet on Twitter, doesn't have any flashy first-author publications, and has only been in the field for ~1.5 years, but people in AI know he was one of the most important people behind Gemini's success
@LasVegasTodd @ycombinator After reviewing all of the startups, it is a tsunami. The wave will crash, but everything will be changed by it. This is not like crypto. New AI technology (eg LLM) have myriad tangible applications. We’re going to see mass, rapid transformation across all industries.