Levon @HalabelianLab

Drug Discovery | Structural Biology | WDR protein family | PI at the SGC-University of Toronto | all opinions are my own. thesgc.org/profile/toront… SGC-Toronto Joined March 2023

Tweets

7
Followers

26
Following

62
Likes

19

Levon @HalabelianLab

2 years ago

Our recent crystal structure of TREX1 in complex with a small molecule inhibitor is now available online. #drugdiscovery #cachechallenge rcsb.org/structure/8VL7

0 0 2 200 0

Structural Genomics Consortium (SGC) @thesgconline

2 years ago

New Blog Post 📢 Learn how @HalabelianLab utilizes AI-driven hit-finding technologies to discover small molecules targeting the WDR protein family and help elucidate the dark proteome. #OpenScience #drugdiscovery #AI thesgc.org/node/1649725

1 1 3 402 0

Structural Genomics Consortium (SGC) @thesgconline

2 years ago

A comprehensive study by @HalabelianLab reveals the interaction of a small molecule which binds to Cbl-b and acts as an intramolecular glue locking the protein in an inactive state. Read more: nature.com/articles/s4200…

0 3 3 1K 1

Communications Biology @CommsBio

2 years ago

Structural and biophysical characterization of a small molecule binding to Cbl-b E3 ligase reveals an intermolecular glue mechanism locking the protein in an inactive state: nature.com/articles/s4200… @HalabelianLab @thesgconline

0 2 2 632 1

Structural Genomics Consortium (SGC) @thesgconline

2 years ago

WDR proteins are a large, druggable, and underexplored target class with strong disease associations. @HalabelianLab just released several WDR structures in complex with inhibitors, which were identified using DEL-ML, in collaboration with @Relay_Tx, @XChemInc and @Google.

1 3 7 2K 1

Levon @HalabelianLab

3 years ago

Exciting to share that our DCAF1 manuscript is now available online. It was great collaborating with the OICR team to advance this molecule into a nanomolar affinity DCAF1 ligand.

Structural Genomics Consortium (SGC) @thesgconline

3 years ago

Exciting to share that our DCAF1 manuscript is now available online. It was great collaborating with the OICR team to advance this molecule into a nanomolar affinity DCAF1 ligand.