Kohli Lab @KohliLab
Studying DNA-modifying enzymes & pathways that add complexity to genomes. Tweets crowdsourced from overworked lab members & not Rahul Kohli unless tagged #RMK. kohlilab.org Philadelphia, PA Joined October 2017-
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Big congrats to Keisuke Yamada (@KohliLab/@ShiLab_UPenn grad student) for winning the 1st place poster award at last week's Deaminet 2025 6th International Conference on Base Editing, Prime Editing & Related Enzymes!
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Thanks to @PennMedBench for featuring our research on structural insights into the SOS response, a key pathway in the evolution of antibiotic resistance in bacteria. Check out the June 2024 Benchmarks issue & lead author @michael_cory22's tweetorial below! mailchi.mp/uphs/penn-medi…
Congrats to Michael! With thanks to great collaborators & the kind reviewer who echoed our excitement saying, “After ~50 years of study, we finally have a detailed model for how RecA catalyzes the autocleavage of LexA…” @BMBGGUPENN @PennChemistry @BB_UPenn
Kohli Lab retweeted
TET1-mediated germline reprogramming & sperm methylome patterning ft. Rexxi Prasasya, Blake Caldwell, Zhengfeng Liu, Songze Wu, @Marisa_S_B (@PennCDB), Johanna Fowler, Steven Cincotta, Diana Laird, @KohliLab (@PennMedicine) & N. Adrian Leu (@pennvet) tinyurl.com/49rferp4
Kohli Lab retweeted
Congrats to Rexxi Prasasya on work showing importance of TET1 to germline reprogramming beyond imprinted & meiosis genes--sperm HMRs. Thanks to collabs-@KohliLab & Diana Laird Iterative oxidation by TET1 is required for reprogramming of imprintin..sciencedirect.com/science/articl…
Base editors are transformative precision genome editing tools. But do we really understand how Cas9 & DNA deaminases work together to shape editing outcomes? See how Kiara tackled this Q below to introduce both a powerful diversifying editor & new mechanistic model for BEs! 🧵👇
Base editors are transformative precision genome editing tools. But do we really understand how Cas9 & DNA deaminases work together to shape editing outcomes? See how Kiara tackled this Q below to introduce both a powerful diversifying editor & new mechanistic model for BEs! 🧵👇
It was a joy to be part of this collaborative effort and expand our own interest in base editors to the world of RNA BEs. Congrats to @HugoMedinaMunoz and all the other authors! Read about using rBEs in PRINTER to study RNA-protein interactions 👇 nature.com/articles/s4146…
It was a joy to be part of this collaborative effort and expand our own interest in base editors to the world of RNA BEs. Congrats to @HugoMedinaMunoz and all the other authors! Read about using rBEs in PRINTER to study RNA-protein interactions 👇 nature.com/articles/s4146…
Kohli Lab retweeted
Registration is now open for the 5th International Conference On Base Editing, Prime Editing & Related Enzymes (aka Deaminet 2024), held January 17- 19, 2024, in San Diego, California at the Estancia La Jolla Hotel. Precision gene editing + San Diego =✌️ cancerresearch.uci.edu/seminars-and-e…
Congrats to @michael_cory22 for being awarded the Kanefield Prize for Research @pennbgs! Michael’s dissertation work on bacterial DNA repair via the SOS response pathway provides key insights to help combat antibiotic resistance, a major concern among #CysticFibrosis patients.
We had a wonderful time at this year’s @PennEpiInst retreat! So very many great talks and posters 🤩 Shoutout to @ChristianLoo_ on winning a poster prize!
Hey @BMBGGUPENN @BB_UPenn labs, did you hear? We’re COOL 😎. Be like us! #GetVaccinated! And then #RideTheSHOTWAVE by posting a picture of your bandaid to help others get access to vaccines!
Hey @BMBGGUPENN @BB_UPenn labs, did you hear? We’re COOL 😎. Be like us! #GetVaccinated! And then #RideTheSHOTWAVE by posting a picture of your bandaid to help others get access to vaccines!
Loving this @epigenie feature on our new DM-Seq method for direct enzymatic sequencing of 5-methylcytosine..."a DM you'll want to slide into." We agree! Slide on over to the link below 🛝👇. And then go #RunDMSeq🧬! epigenie.com/dm-seq-a-dm-yo…
Congratulations to our newest PhD candidate @AleksiaBarka for successfully passing her @BMBGGUPENN prelim exam (and doing it before officially starting grad school, no less)!
Being able to limit the size & control the copy number of genomic information in a human artificial chromosome would be a major step forward...and here it is! 🧑🦰🤖🧬 See below for must-read work from the lab of Ben Black @BB_UPenn @PennGenomeInteg 👇 biorxiv.org/content/10.110…
Excited to share our new paper @ACSPublications! We melded our biochemistry expertise + @CisnerosRes computational expertise to turn a natural DNA methyltransferase (MTase) into a neomorphic DNA carboxy-MTase with novel substrate selectivity🧬. See the tweetorial below for more👇
Excited to share our new paper @ACSPublications! We melded our biochemistry expertise + @CisnerosRes computational expertise to turn a natural DNA methyltransferase (MTase) into a neomorphic DNA carboxy-MTase with novel substrate selectivity🧬. See the tweetorial below for more👇
Kohli Lab retweeted
Congratulations to Wumesh KC (@PennCardiology), @KreiderTed (@WeissmanLab) & Elizabeth Traxler (@PennCancer) on being selected as members of the 1st cohort of the @Penn Measey Scholars in Molecular Medicine Program!🎉 Learn more➡️ molmedscholars.org
Kohli Lab retweeted
Novel DM-Seq Method Profiles 5mC at Single-Base Resolution Using Nanograms of DNA A new, precise, and efficient DNA sequencing method, direct methylation sequencing (DM-Seq), may lead to easier testing and earlier cancer detection...Read more: ow.ly/7PlA50OQn25
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