Jakub Kopal @KopalJakub
@MSCActions postdoctoral fellow at @SFFNORMENT Joined June 2015-
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#Multimorbidity is a pressing challenge in health care. We dissect its genetic architecture across mental and physical health, revealing shared and distinct links between brain structure, psychiatric disorders, and cardiometabolic disease. medrxiv.org/content/10.110…
Understanding #Parkinsons subtypes is key to more targeted RCTs & better therapeutics! 🧠 Our new study finds that LRRK2 PD patients show milder cortical atrophy, with preserved temporal & occipital regions compared to sporadic PD. #LRRK2 #dataviz medrxiv.org/content/10.110…
"Copy number variants and the tangential expansion of the cerebral cortex". Work led by Zhijie Liao & Tomas Paus, out in @NatureComms, investigating the rare genetic architecture of the human cerebral cortex. doi.org/10.1038/s41467… Read content here: rdcu.be/eagHX
Impressive and important work by @KevinOC87, @oleaandreassen and collaborators in @PGCgenetics on the genomics of bipolar disorder published in @Nature 👏 ➡️ tinyurl.com/33krpxbd @UniOslo_MED @Oslounivsykehus med.uio.no/klinmed/englis…
Job alert!🚨 3-year postdoc position available at the Centre for Precision Psychiatry related to multimodal prediction algorithms for Alzheimer’s disease using data from genetics, neuroimaging, biomarkers and cognitive tests. Deadline Feb 6. Please share! jobbnorge.no/en/available-j…
New preprint! Strong genetic overlap between severe mental disorders and blood metabolic markers. Fascinating patterns: opposite effect directions of the markers on major depression versus bipolar disorder and schizophrenia. tinyurl.com/metaboPsych. #metabolicpsychiatry
Out now ! Key points: -Big neuroscience datasets are not big small datasets -Lion’s share of variation in brain measurements is not necessarily specific to a neuroscience questions -major brain disorders exhibit subpopulation-related divergences -Standard deconfounding tools,…
Out now ! Key points: -Big neuroscience datasets are not big small datasets -Lion’s share of variation in brain measurements is not necessarily specific to a neuroscience questions -major brain disorders exhibit subpopulation-related divergences -Standard deconfounding tools,… https://t.co/64Bx6Wb2UZ
Scientists when asked for their data "upon reasonable request"
Scientists when asked for their data "upon reasonable request"
@KopalJakub 2nd talk at #OHBM2024 where he explored how copy number variations (CNVs), a significant source of genetic variation, play a crucial role in shaping the complex relationship between the brain and behavior.
Modern neuroscience leverages large datasets to embrace diversity missed in smaller studies, requiring revised modeling practices. Jakub @KopalJakub discusses new analytic paradigms identifying nuanced drivers instead as key variables is crucial for impactful findings. #Diversity
New preprint explores how rare high-effect gene-coding variants (#CNVs) shape brain architecture and influence cognitive and socio-behavioral traits in adolescents (#ABCD). medrxiv.org/content/10.110…
👏👏Finally out!! Our new study called copy number variants in ABCD study, identified genetic associations with dimensions of psychopathology and cognitive development in ~10,000 children. Please check it out. Thanks @Aaron_A_B, Joe and other coauthors.👍 medrxiv.org/content/10.110…
New post-doc positions in our team. Please DM if you are interested.
🗞️Excited to share our latest preprint on the shared genetics of common epilepsies and general cognitive ability (COG). doi.org/10.1101/2024.0… 🧬We showed almost complete overlap between common epilepsies and COG, and identified 66 distinct loci shared between these phenotypes.
With @danilobzdok, we leveraged rare genetic mutations (#CNVs) to revisit structural brain #asymmetry. Planum temporale emerged as especially susceptible to deletions & duplications of specific gene sets. nature.com/articles/s4146…
16p11.2 BP4-5 #CNVs are associated with broad and highly heterogeneous phenotypic alterations, but can we learn about the mechanisms behind this #pleiotropy? 🧬🕵🏻♀️ This is the question that our new preprint addresses!👇🏻🧵 rb.gy/qx6xjc #RareDisease #GenomicDisorder 💫
Delighted to be awarded #msca postdoc fellowship by @MSCActions to study genetics of human development at @SFFNORMENT with @oleaandreassen. Big thanks to @UniOslo @DvdM33r @ParekhPravesh for the support.
🎉🥳Our 6th @OHBM_DIC Symposium w/ @LucinaUddin, Julia Kam, and Davynn Tan on "Diversity, Equity, and Inclusivity in Artificial Intelligence and Neuroimaging" has been accepted for #OHBM2024, featuring a fantastic lineup: @yip_lab , Zhiyi Chen, Jingwei Li, and Jakub Kopal !
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