Michael Galperin @MicroGap
Bacterial signaling, c-di-GMP, c-di-AMP, protein domains NCBI's Comp. Bio. Branch, COG database, J. Bacteriology Bethesda, MD Joined May 2016-
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FWIW: New mechanisms for bacterial motility and DNA transfer between bacteria decoded, via @EurekAlert! eurekalert.org/news-releases/…
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Over two years in the making, but here it is: ComFB, the third family of c-di-GMP receptor proteins with representatives in multiple bacterial phyla (PMID: 40966295) doi.org/10.1073/pnas.2…
Michael Galperin retweeted
Analysis of essential genes in Clostridioides difficile by CRISPRi and Tn-seq | Journal of Bacteriology journals.asm.org/doi/10.1128/jb…
Some thoughts on metabolism and metabolic pathway holes pnas.org/doi/10.1073/pn….
Lara Amorim, Conceição Santos and Kenneth Timmis Prioritising Microbiology in Secondary Education Addresses Emerging Scientific-Social-Educational Challenges and Competency Needs …icro-journals.onlinelibrary.wiley.com/doi/10.1111/17…
Michael Galperin retweeted
Incredible! Fascinating piece by Elisabeth Bik @MicrobiomDigest Discontinuous ridiculous stools – a preprint full of tortured phrases and stolen data scienceintegritydigest.com/2025/07/28/dis… h/t @RetractionWatch
The interactions of c-di-GMP with the acidic residues seen in the MshEN domain could be quite widespread onlinelibrary.wiley.com/doi/10.1002/an… Protonated Glutamate and Aspartate Side Chains Can Recognize Phosphodiester Groups via Strong and Short Hydrogen Bonds in Biomacromolecular Complexes
An interesting discussion: c-di-GMP does not bind H-NS, nor inhibits H-NS binding DNA | Nat. Comm nature.com/articles/s4146… (PMID: 40506437) Reply to: “c-di-GMP does not bind H-NS, nor inhibits H-NS binding DNA” | Nat. Comm nature.com/articles/s4146… (PMID: 40506445)
Lee Kroos et al. (17 authors) From the humblest of beginnings (i.e. a pile of dry cow dung) over 80 years ago, the Gram-negative bacterium Myxococcus xanthus has emerged as a premier model system for studying diverse fields of bacteriology journals.asm.org/doi/full/10.11…
Michael Galperin retweeted
Very happy to share that a large part of my thesis work is out today: B. subtilis uses the second messenger c-di-AMP to modulate its turgor pressure in response to the state of its cell envelope. nature.com/articles/s4156…
In the architecture of the outer membrane complex PelBC for Pel export, the essential periplasmic ring of twelve PelC lipoproteins is mounted on top of the PelB β-barrel nature.com/articles/s4146…
In Bacillus subtilis, c-di-AMP levels are modulated by the cyclase regulator CdaR in response to cell wall defects. Great work by @apbrogan.bsky.social et al. nature.com/articles/s4156…
This paper offers a solution to a long-standing problem: A general mechanism for initiating the bacterial general stress response | eLife @nielsbradshaw doi.org/10.7554/eLife.…
Michael Galperin retweeted
We cracked the mystery: Pteridines are the natural ligands of CutA, a widespread protein in nature @HHU_de @CoE_CMFI I started this project 8y ago. We showed that it's of PII signaling family, but it's role remained unknown coz we didn't know what it bind biorxiv.org/content/10.110…
Novel families of selenoproteins journals.asm.org/doi/10.1128/ms…
Congratulations, @shuramankin! nature.com/articles/s4158…
Michael Galperin retweeted
Congratulations to my former postdoc supervisor, Prof. George Salmond. A well-deserved recognition! @MicrobioSoc microbiologysociety.org/news/society-n…
Michael Galperin retweeted
I know one thing. Zelenskyy would’ve received a hero’s welcome from these guys, and sent home with enough ammo to go all the way to Moscow.
Hyperpiliation reduces Pseudomonas aeruginosa pathogenicity journals.asm.org/doi/full/10.11…
Pyruvate kinase of Bacillus subtilis produces GTP ~10 times more efficiently than ATP journals.asm.org/doi/10.1128/mb…
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