MPI Bioinformatics Toolkit (MPI for Biology) @mpitoolkit
An integrative platform for protein sequence and structure analysis. Tweets by @Vikram_Alva https://t.co/An2CMmrOun @MPI_Bio toolkit.tue.mpg.de Tübingen, Germany Joined February 2017-
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We have released a major update to pLM-BLAST, a remote homology detection method based on representations from protein language models such as ProtT5. Check it out on @mpitoolkit (toolkit.tuebingen.mpg.de/tools/plmblast) and GitHub (github.com/labstructbioin…) & see below 🧵 for details!
These are generously funded tenure track positions for female researchers. Application deadline April 10. Consider applying! Lise Meitner Excellence Program mpg.de/lise-meitner-e…
🌱 Thrilled to share our latest research on #BrownAlgae sex determination! Led by Susana Coelho, our team has revealed a fascinating connection between the sex determination processes in brown algae and animals. #Evolution @MPI_Bio science.org/doi/10.1126/sc…
Did you know that sex determination in brown algae and animals shares a fascinating connection? 🌊 Our latest study reveals how HMG-box genes independently drive male sex determination in these distant organisms. 🧬 Take a deeper dive into the paper here: doi.org/10.1126/scienc…
#ScientificBreakthrough Researchers from @MPI_Bio uncover the unique sex-determination gene in #BrownAlgae. Their findings highlight the unexpected shared #genetic toolkit across algae, plants & animals. twtr.to/311ah #Evolution #Biology #Research @ScienceMagazine
Thrilled to share our latest preprint on BiorXiv! A fantastic team effort led by @za_curtis, Pedro Escudeiro, and John Mallon! Check out @Archaeon_Alex's thread for a quick dive into our exciting findings! 🔬
Thrilled to share our latest preprint on BiorXiv! A fantastic team effort led by @za_curtis, Pedro Escudeiro, and John Mallon! Check out @Archaeon_Alex's thread for a quick dive into our exciting findings! 🔬
We have a new story out at BiorXiv! Amazing work led by @za_curtis (Bisson), Pedro Escudeiro (Alva) and John Mallon (Bisson). Great collaboration with @Vikram_Alva (Max Planck) and @pohlschr (UPenn). A summary of our findings in the thread (1/22) shorturl.at/fLPR1
For those of you who missed this post last year, I welcome applications until the end of January. This is approximately 50% bench and 50% computation, involving both microbiology and plant work.
For those of you who missed this post last year, I welcome applications until the end of January. This is approximately 50% bench and 50% computation, involving both microbiology and plant work.
Now published: our study showing how liquid crystals of filamentous phages (termed tactoids) form diffusion barriers, protecting Pseudomonas aeruginosa from antibiotics in biofilms. (1/2) rdcu.be/dtYPO
We are hiring! Calling all outstanding candidates in the field of intelligent systems to establish up to two new W2 independent #research groups at our institute's #Stuttgart site: #Robotics, Human-Machine Interaction, Robotics for #Healthcare, #AI etc. is.mpg.de/jobs/research-…
Delving deeper, we used DAP-seq to reveal that HBb binds along the entire genomic DNA of B. bacteriovorus without sequence specificity. The wonders of bacterial histones continue to unfold! Dive into our manuscript for more details: 👉 biorxiv.org/content/10.110…
🔬New insights on bacterial histones! 🧬 Our study, led by Yimin Hu & @SammyBoterhammy, shows that in Bdellovibrio bacteriovorus, HBb bends DNA uniquely, differently from eukaryotic & archaeal histones. Great collaboration with Birte Hernandez, @DameLab. @MPIBio @LeidenScienceEN
Now online our studies on the role of the Bdellovibrio bacteriovorus bacterial histone in chromatin organization biorxiv.org/content/10.110… Great collaboration between @Vikram_Alva, Birte Hernandez and @DameLab spearheaded by Yimin Hu and @SammyBoterhammy. @MPIBio @LeidenScienceEN
The pLM-BLAST has been published in Bioinformatics! (academic.oup.com/bioinformatics…). It is a tool for remote homology detection by comparing representations derived from protein language models (such as ProtT5). 🔗toolkit.tuebingen.mpg.de/tools/plmblast. See below for more information and examples!
First day of @PAW_Germany! May we introduce @CDuchene3675: Carole is an algae-loving post-doc at @MPI_Bio, where she studies the infection of #brownalgae by marine viruses. She wants to understand the mechanisms that couple the virus cycle to the algal life cycle.
Big congratulations to Andrei Lupas! 🎉🍾 Today, collaborators, former students, lab members and others he met along his way in science gathered at the MPI to celebrate his 60th birthday. 🎂 May his unabated enthusiasm for science bring him many more happy and productive years!
Today is #WorldOceanDay! Let's celebrate - and protect! - the impressive forests of the ocean. This video will make you love kelp:
My friend Helen needs help. Please take a moment to check out my GoFundMe campaign: gofund.me/f97bdcac Thank you so much for your kindness and support. Buzz
📢 Exciting #joboffer! #SelimLab @Selim_Khaled_ is on the lookout for a #postdoc in structural biology #CryoEM, focusing on PII signal transduction proteins. Apply now! Help spread the word - RT! #postdoc #AcademicTwitter
📢 Exciting #joboffer! #SelimLab @Selim_Khaled_ is on the lookout for a #postdoc in structural biology #CryoEM, focusing on PII signal transduction proteins. Apply now! Help spread the word - RT! #postdoc #AcademicTwitter
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These are generously funded tenure track positions for female researchers. Application deadline April 10. Consider applying! Lise Meitner Excellence Program mpg.de/lise-meitner-e…
🌱 Thrilled to share our latest research on #BrownAlgae sex determination! Led by Susana Coelho, our team has revealed a fascinating connection between the sex determination processes in brown algae and animals. #Evolution @MPI_Bio science.org/doi/10.1126/sc…
Did you know that sex determination in brown algae and animals shares a fascinating connection? 🌊 Our latest study reveals how HMG-box genes independently drive male sex determination in these distant organisms. 🧬 Take a deeper dive into the paper here: doi.org/10.1126/scienc…
#ScientificBreakthrough Researchers from @MPI_Bio uncover the unique sex-determination gene in #BrownAlgae. Their findings highlight the unexpected shared #genetic toolkit across algae, plants & animals. twtr.to/311ah #Evolution #Biology #Research @ScienceMagazine
Thrilled to share our latest preprint on BiorXiv! A fantastic team effort led by @za_curtis, Pedro Escudeiro, and John Mallon! Check out @Archaeon_Alex's thread for a quick dive into our exciting findings! 🔬
We have a new story out at BiorXiv! Amazing work led by @za_curtis (Bisson), Pedro Escudeiro (Alva) and John Mallon (Bisson). Great collaboration with @Vikram_Alva (Max Planck) and @pohlschr (UPenn). A summary of our findings in the thread (1/22) shorturl.at/fLPR1
We have a new story out at BiorXiv! Amazing work led by @za_curtis (Bisson), Pedro Escudeiro (Alva) and John Mallon (Bisson). Great collaboration with @Vikram_Alva (Max Planck) and @pohlschr (UPenn). A summary of our findings in the thread (1/22) shorturl.at/fLPR1
For those of you who missed this post last year, I welcome applications until the end of January. This is approximately 50% bench and 50% computation, involving both microbiology and plant work.
A PhD position is available in my group at @_SLU starting in 2024 thanks to a new grant from @Vetenskapsradet. The application deadline is 31 Jan. 2024. The preferred start date is late spring or summer 2024. Apply via this link: slu.se/en/about-slu/w… More details in thread 👇
Now published: our study showing how liquid crystals of filamentous phages (termed tactoids) form diffusion barriers, protecting Pseudomonas aeruginosa from antibiotics in biofilms. (1/2) rdcu.be/dtYPO
How do you study a family of protein domains whose function depends on their dynamics? Let's model 5000 homologs with AlphaFold2 and see what happens. The case of dimeric HAMP domains of prokaryotic signal transduction proteins: onlinelibrary.wiley.com/doi/full/10.10…
We are hiring! Calling all outstanding candidates in the field of intelligent systems to establish up to two new W2 independent #research groups at our institute's #Stuttgart site: #Robotics, Human-Machine Interaction, Robotics for #Healthcare, #AI etc. is.mpg.de/jobs/research-…
Delving deeper, we used DAP-seq to reveal that HBb binds along the entire genomic DNA of B. bacteriovorus without sequence specificity. The wonders of bacterial histones continue to unfold! Dive into our manuscript for more details: 👉 biorxiv.org/content/10.110…
🔬New insights on bacterial histones! 🧬 Our study, led by Yimin Hu & @SammyBoterhammy, shows that in Bdellovibrio bacteriovorus, HBb bends DNA uniquely, differently from eukaryotic & archaeal histones. Great collaboration with Birte Hernandez, @DameLab. @MPIBio @LeidenScienceEN
Now online our studies on the role of the Bdellovibrio bacteriovorus bacterial histone in chromatin organization biorxiv.org/content/10.110… Great collaboration between @Vikram_Alva, Birte Hernandez and @DameLab spearheaded by Yimin Hu and @SammyBoterhammy. @MPIBio @LeidenScienceEN
Thanks to all authors from @ibe (Kamil Kamiński, Jan Ludwiczak, and @MiTRonGTE ) and @MPI_Bio (@Vikram_Alva) and to @fnp and @MPI_Bio for funding! 🙂
In the example above, pLM-BLAST was used to detect a Cache domain in a prokaryotic signaling protein. We believe that pLM-based homology detection combined with AlphaFold2 predictions can be a powerful tool for annotating yet uncharacterized proteins.
The benchmark against the Evolutionary Classification of Protein Domains database showed that pLM-BLAST detects homology with an accuracy comparable to HHpred while providing new interesting connections.
The pLM-BLAST has been published in Bioinformatics! (academic.oup.com/bioinformatics…). It is a tool for remote homology detection by comparing representations derived from protein language models (such as ProtT5). 🔗toolkit.tuebingen.mpg.de/tools/plmblast. See below for more information and examples!
First day of @PAW_Germany! May we introduce @CDuchene3675: Carole is an algae-loving post-doc at @MPI_Bio, where she studies the infection of #brownalgae by marine viruses. She wants to understand the mechanisms that couple the virus cycle to the algal life cycle.
Two ERC Starting Grants @ERC_Research for @mpicbg research group leaders Agnes Toth-Petroczy @agnestothp and Alexander von Appen to launch their own projects. Congratulations! mpi-cbg.de/news-outreach/…