Niko Klink @NikolasKlink
PhD candidate @Gerschlab at the CGC of the @MPImoph and @TU_Dortmund. Fascinated by drug discovery and all things Ubiquitin. Joined September 2022-
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New Parkinson’s disease paper: Chimeric deubiquitinase engineering reveals structural basis for specific inhibition of USP30 and a framework for DUB ligandability - published by @MalteGersch group @maxplanckpress in @Nature Struct. & Mol. Biol. nature.com/articles/s4159…
Excited to share that our work on Parkinson's target USP30 has been published in Nature Structural & Molecular Biology! By combining DUB-domains onto USP30, we for the first time achieved crystallization with a small molecule (NK036) without Nanobodies! nature.com/articles/s4159…
Fighting drug-resistant GIST!🚀 We developed innovative covalent KIT/PDGFRA inhibitors using structure-based design. Check out our latest J Med Chem publication! doi.org/10.1021/acs.jm… #CancerResearch #DrugDiscovery
Kicking off the new year properly: In collaboration between the labs of @giuliosf and @alessiociulli we found that the efflux pump ABCC1/MRP1 constitutively restricts PROTAC sensitivity in cancer cells. Out in @CellChemBiol cell.com/cell-chemical-…
Read how deubiquitinases USP53 and USP54 cleave long polyubiquitin chains and how the former is linked to liver disease in children. mpi-dortmund.mpg.de/news/new-enzym…
Very excited to share that our manuscript on the "Discovery and mechanism of K63-linkage-directed deubiquitinase activity in USP53" was published today at Nature Chemical Biology @nchembio. Congratulations Kim, Kai, and all authors! nature.com/articles/s4158…
Very excited to share that our manuscript on the "Discovery and mechanism of K63-linkage-directed deubiquitinase activity in USP53" was published today at Nature Chemical Biology @nchembio. Congratulations Kim, Kai, and all authors! nature.com/articles/s4158… https://t.co/2aYW6MW7C5
Tomorrow, November 26, we are looking forward to hosting @georg_e_winter from @CeMM_News, Austrian Academy of Sciences, Vienna, at @crc1430 @unidue. Join us for his exciting talk on small-molecule degraders!
“We’re very excited to see what people do with this” AlphaFold3 is open at last go.nature.com/4fHAfio
I had such a great time at this years AEK autumn school on #degraders and bringing them towards clinical applications. Fantastic Talks from both academia and Industry. I learned alot, got to see old friends and made New ones. Im bringing home great memories and a bunch of notes!
Caspase-2 is a condensate-mediated deubiquitinase in protein quality control: nature.com/articles/s4155…
Looking for E3 / PROTAC / glue or DUB / DUBTAC substrates? Proxy-Ubiquitomics might be the way - applied here to USP30 @AndreasDamiano2 Hannah Jones @ProteomOX biorxiv.org/cgi/content/sh… #biorxiv_molbio
In this work, @alessiociulli, @DLZollman, and @UoDCeTPD design and validate a truncated CRBN construct, CRBNmidi, that enables crystallization and biophysical characterization of CRBN-binding ligands and degraders. #TPD #PROTAC nature.com/articles/s4146…
We’re delighted to be partnering with @alleolabs to accelerate DUB-focused drug discovery! This collaboration will combine Alleo’s AI-based platform with our expertise in the DUB space to advance DUB-focused preclinical programmes. ➡ tinyurl.com/283d7o5o
We are excited to share our latest work in context of the colaborative research consortium 1430 @crc1430. A preprint is available on bioRxiv (doi.org/10.1101/2024.1…).
Long non-coding RNA GRASLND links melanoma differentiation and interferon-gamma response - published by the Imig group in @FrontiersIn Molecular Biosciences frontiersin.org/journals/molec…
Honored to have presented my and our @Gerschlab research at this great conference! Looking forward to two more days!
Honored to have presented my and our @Gerschlab research at this great conference! Looking forward to two more days!
Proud to share our work on this fascinating enzyme and inhibitor class, congrats to everyone involved! This story is definetly worth a read. Cant wait to hear Feedback on our DUB ligandability proposal aswell!
Proud to share our work on this fascinating enzyme and inhibitor class, congrats to everyone involved! This story is definetly worth a read. Cant wait to hear Feedback on our DUB ligandability proposal aswell!
Our new paper demonstrating reversible ubiquitylation of DNA and RNA: embopress.org/doi/full/10.10…
❗📚💡 PROTAC-DB 3.0: an updated database of PROTACs with extended pharmacokinetic parameters academic.oup.com/nar/advance-ar… #TPD #Targeted_Protein_Degradation
📢New lab preprint: 2.05 A #cryoEM structure of UapA: unprecedented aspects of the elevator-type transport (incl. water, lipids) and regulatory roles of the N-tail. With Diallinas, Mikros labs. Kudos @broutzakis and all co-authors. @uni_muenster #SoN biorxiv.org/content/10.110…
Mahendra Palecha @imshymaple
64 Followers 668 Following Living life is nothing but enjoying every moment.
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SHUBHAM @SHUBHAM38420581
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jake @mediocre_jake
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Interact 2025 @Interact2025
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Jan Hane @JanHane_
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Andrés F. Correa Sá... @A_CorreaSanchez
117 Followers 341 Following Synthesizing oligos and drinking coffee at @NATA_MRC_UK
Nikhil @Narendradev_N
430 Followers 3K Following Graduate student at @tvmiiser. Fulbrighter. Loves 🌊⛰🏊♀️ 🇮🇳🇸🇬🇲🇾🇩🇰🇵🇱🇺🇸 #mitochondria🔬 #ubiquitin #proteomics +114.043 #TeamMassSpec
PGehrtz @GehrtzP
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Cristian Prieto-Garci... @CristianPG_mlg
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Giulia @Ella_Joy_
83 Followers 115 Following "The greatest glory in living lies not in never falling, but in rising every time we fall."
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Aitana de la Cuadra B... @DeLaCuadraBaste
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Will Thompson @Will_thompson96
134 Followers 203 Following Anticancer MedChem PhD researcher @UniofNewcastle | Targeted protein degradation | Just a big nerd 🎮 🏳️🌈 (he/him)
Alessandra Salerno �... @ales_salerno
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Ilaria Puoti @IPuoti
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137 Followers 487 Following #SBDD #NurixTherapeutics #Biophysics #DEL #Proteindesign #ProteinChemistry #ProteinScience #TPD #ProteinDegradation All expressed opinions are my own.
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84 Followers 215 Following We are RTG-PRO, a DFG-funded research consortium with the aim to gain better understanding of proteases in infection and inflammation. Follow us on our journey!
Amelie Heuer-Jungeman... @Amelie_HJ
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