Presenting the science behind the lasting adverse effects of common pharmaceuticals: https://t.co/n6uMWdwkWe
Substack: https://t.co/JKJAzz7tS8Joined November 2023
The goal of SSRIs is to disable the inhibitory effect of the 5-HT1A autoreceptor so that more serotonin reaches postsynaptic heteroreceptors. Evidence suggests SSRIs do exactly this, but their long-term impact on 5-HT1A may undermine this effect.
Early in SSRI treatment, the…
The microbiome - the trillions of bacteria, viruses, and fungi in your gut - aren’t invaders but symbiotic partners. They break down carbs into short-chain fatty acids (SCFAs), synthesise essential vitamins, and even influence epigenetic processes throughout the body.
One of the…
The “gut” isn’t just for digestion - via the gut–brain axis, it influences our mood and cognition: with more than 50% of dopamine in the body being synthesised in the gut.
Yet SSRIs may exert antimicrobial effects, reducing key bacteria (e.g. Ruminococcus, Oscillospira,…
Despite being considered as an afterthought at best by most prescribers, individual genetics can dramatically alter the risk of side effects when taking SSRIs.
Single-nucleotide polymorphisms (called SNPs for short) are simple ‘letter’ swaps in the DNA code. Just one of these…
Isotretinoin - commonly known as Accutane - is a vitamin A derivative that’s proven highly effective at permanently clearing severe acne. Yet, after four decades of use, scientists still aren’t exactly sure why it works.
Over time, isotretinoin has raised growing concerns for…
Finasteride has become a staple for maintaining a youthful hairline - once prized mainly by actors/models, it’s now prescribed by online pharmacies after brief questionnaires. As of 2024, its U.S. market tops $120 million and continues to grow.
Just 1 mg of finasteride per day…
Post-SSRI Syndrome (PSSD) is a condition where debilitating symptoms persist - or even emerge - after stopping serotonergic meds like SSRIs or SNRIs. Though these drugs treat depression/anxiety, a subset of patients paradoxically worsen.
Alarmingly, adverse responses can endure…
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