Research365 @Research365

A hedge fund returned 50% a year for ten years straight. In 2005 the man who ran it sat on a desk at Columbia and taught the entire method to 30 students for free. No bank, no fund, no business school has ever promoted the recording. His name is Joel Greenblatt. He ran Gotham Capital from 1985 to 1994. Almost nobody sustains 50% annually for a single year. He did it for ten. Then in 1995 he returned all outside capital, kept running his own money, and walked into a classroom. The first lecture is about corners of the market where the usual buyers are structurally forced to sell regardless of price. Spinoffs, restructurings, situations where an index fund must dump a stock the day it leaves the index. He does not teach a screener or a formula. He teaches why these corners exist at all, and why they keep existing after everybody knows about them. The uncomfortable part is what he says about diversification. He held very few positions. It runs directly against everything the business school teaches two floors down. Columbia charges $80K a year in tuition. The man upstairs gave away the method for free. Every screener is free now. Every filing is searchable. The constraint was never information. It was knowing which information to ignore. Filmed from the back row, audio uneven, students blocking the frame. He gave away 50% a year to a room of 30 people. Almost nobody traded on it. One classroom. One camera. The full lecture is free. It is in the video.

Tigerflow @tigerfl0w

3 months ago

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"Soluble vs insoluble" is one of the most enduring oversimplifications in nutrition. Two fibers in the same label bucket can do completely opposite things in your body. Fiber has at least four properties that vary independently: • Solubility (does it dissolve in water?) • Viscosity (does it form a gel?) • Fermentability (do colon bacteria eat it?) • Physical structure (intact or particulate?) Each property drives a different outcome. The label binary collapses all four into one. Examples: Cellulose (wheat bran, vegetables). Insoluble, non-viscous, barely fermented. Bulks stool, speeds transit. No metabolic effects. β-Glucan (oats, barley). Soluble, highly viscous, moderately fermented. Lowers LDL via bile acid sequestration. The FDA-approved oat health claim is built on this property. Psyllium. Soluble, highly viscous, poorly fermented. Survives intact through the colon. Lowers LDL. Normalizes stool (works for both constipation and diarrhea). Inulin / FOS (chicory, onions, garlic). Soluble but non-viscous. Highly fermentable. Bifidobacteria use it as substrate to produce SCFAs. Minimal LDL effect. Can bloat. Resistant starch (cooked-cooled potato, green banana). Insoluble but highly fermentable. Produces butyrate, the primary fuel for colonocytes (~70% of their ATP). Why the binary fails: Inulin and psyllium are both labeled "soluble fiber." Inulin ferments completely, produces SCFAs, has only minimal LDL effects. Psyllium passes through largely intact and lowers LDL via bile acid sequestration. They share one property and differ on every other one that matters. Practical translation. Match the fiber to the outcome: • LDL drop → viscous fibers (psyllium, β-glucan, raw guar gum) • Microbiome support → fermentable fibers (inulin, FOS, resistant starch) • Regular stools → either viscous gel-formers or coarse insoluble particles The label binary doesn't tell you which is which. The properties do. McRorie & McKeown, J Acad Nutr Diet, 2017 Donohoe et al., Cell Metab, 2011

You're not depressed, you just lost your quest.

DAN KOE @thedankoe

8 months ago

The problem is that you don't know what you want to do, and figuring out what you want to do requires learning, experimentation, and effort - so you do nothing.

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i'm mastering the art of being silent, even when there's a lot to be said. silence is the best reply to someone who doesn't value your words. break those patterns. no more repeated cycles. it’s time to grow.

Regular exercise reduces the likelihood of plaque accumulation in the arteries However, many long-term exercisers appear to have coronary artery calcification, indicating atherosclerosis progression The fascinating thing is that despite the higher plaque, those people still have lower rates of cardiovascular disease events and mortality Full video youtu.be/S-NKPZSkbXg Graph: academic.oup.com/eurheartj/adva…

“… it is plausible and consistent with earlier work that, relative to soil- and dust-derived PM2.5, combustion and industrial sources are more likely to activate biological responses contributing to atherosclerosis and ischemic heart disease.” 🫀 eviden.cc/3V6iOjr

Energy givers vs Energy drainers

In 1636, one tulip bulb cost more than an Amsterdam mansion. 150 times a craftsman's salary. Worth $25,000 in today's money. People sold houses for flowers. Then in February, the market collapsed by 90% in weeks. Here's how the Dutch lost their minds... 🧵

The ingredient that's even worse than Sugar: Maltodextrin It's hiding in your favorite chips, yogurt, cereals, protein powder, and even in baby formula. While the manufacturers claim that your food is sugar-free, everyone's missing this scary truth... A thread 🧵

#zhuyilong was wearing: Gaurav Gupta 2022 Tuxedo Jimmy Choo boots Chopard watch

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THE ONLY REAL LOOKSMAXXING THREAD | EVERYTHING YOU NEED TO KNOW🧵 BOOKMARK!

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Great! 👌

You've heard of copper peptides, but GHK-Cu is just scratching the surface of what's possible in biohacking. In fact, copper peptides were discovered in the '70s, and we've come a long way since then. Peptides are short chains of amino acids that can easily penetrate your skin. In skincare, peptides act like messengers by signaling your body to perform specific functions like collagen production and repair. For topicals, we use bioactive peptides which are typically made of between ~2-10 amino acids. At a high level, when your skin is injured, your body naturally responds by proteases breaking down the tissue into - you guessed it - peptides. So, you've got these peptide fragraments, and your body realizes you're injured and begins to repair itself in a process we refer to as wound healing. Because it's the peptides that signal to your body that it needs to repair itself, we can extend that logic to skincare and induce a wound healing response by applying peptides topically. This is an example of how signalling peptides work, but that's not at all peptides are good for. So, what are the main types of peptides available to us? ✨ Signal Peptides They tell your skin cells to produce more collagen, elastin, epidermal growth factor (EGF-1), hyaluronic acid, and other components of your skin that contribute to firmness and elasticity. ✨ Neurotransmitter Inhibitor Peptides These guys work by limiting muscle movement, reducing the potential for the development of fine lines and wrinkles. You can think of these like topical versions of Botox, though they're not nearly as effective. Matrixyl 3000 ✨ Carrier Peptides These peptides deliver trace elements like copper and manganese, wand they support wound healing and enzymatic processes. GHK-Cu falls into this category. ✨ Enzyme Inhibitor Peptides Certain enzymes, like tyrosinase, contribute to skin conditions we don't like, like dark spots/ hyperpigmentation. Other enzymes can even degrade your collagen and elastin, leading to wrinkles. Peptides that target these enzymes are, perhaps obviously, known as enzyme inhibitors. We also have antimicrobial peptides, but they're not as interesting to talk about. And, well, the name says it all. So, benefits of peptides distilled: ✨ They're good for reducing and preventing signs of aging like fines and wrinkles ✨ They support wound healing and skin regeneration ✨ They support skin barrier function, improving your body's ability to hang onto water and reducing the rate at which your collagen degrades ✨ They're generally well-tolerated, especially compared to retinoids and vitamin C, making them suitable for nearly everyone to use. Some studies even show that certain peptides outperform retinol and l-ascorbic acid. Now, you'll generally find peptides in serums, moisturizers, and eye cream. The efficacy of the exact product will depend on its stability, formulation, and the concentration of peptides in the product. To use a peptide serum: Wash your face -> apply 3-5 drops and gently massage until absorbed -> moisturize as needed You'll need to use peptides consistently for them to work, but copper peptides are so potent that some people notice results in a few days. As with anything in skincare, you need to exercise patience and consistency. Give it time, and you'll see improvements in the firmness and elasticity of your skin.

Stretching the Quads is an easy win for people who struggle with fitness resolutions. There is so much tension stuck in there. You don't realize how much the pressure affects your joints and posture until it's gone. A few sets twice a week take you a long way. 6 Quad Stretches to Free Your Legs in 2024: Stretching your Quads is simple - Pull your foot toward your hip, and hold. Some positions might be more challenging than others. Do 2-4 sets of 30 -60 seconds/leg. 1. Lying [0:03] 2. Side-Lying [0:19] 3. Kneeling [0:29] 4. Lean Back (One leg) [0:39] 5. Lean Back (Two legs) [0:48] 6. Standing [0:57] Great things happens when you clear the tension out of the muscles along the front of your legs. There is less pressure on your hips and knees, and a lot more space to move effectively.

No one in America pays as high a tax rate an an employee with a high salary But that doesn't mean you can't do anything to optimize it If you have a high W-2, here are 15 things you can do to pay less in taxes this year:

American hedge fund billionaire Bill Ackman is a big fan of self-studying investing. "You can learn investing by reading books." Here is the 11-Book-List that he recommends to everyone who wants to learn about Investing👇

All 4️⃣ GI Society Guidelines in 1️⃣ Place @AGA_Gastro 48 guidelines @AmCollegeGastro 55 guidelines @ASGEendoscopy 83 guidelines @AASLDtweets 23 guidelines Google folder: 🔗 drive.google.com/drive/folders/… Save this link & quickly download all PDFs Updated as 🆕 guidelines published!

📄 20 studies that Internal Medicine Residents should read in the first year 👇 1/ 🏃‍♀️ RACE II trial: Lenient resting HR < 110 was non-inferior to a strict HR < 80 in patients with atrial fibrillation. 🧵