ShoagLab @ShoagLab
Studying prostate cancer, somatic mutations, and aging Cleveland, OH Joined March 2026-
Tweets5
-
Followers12
-
Following44
-
Likes2
ShoagLab retweeted
Very excited to share our new paper, published in Cell! We found that caloric restriction (CR) in mice reduces somatic mutation burdens across the genome, and that this effect has some surprising features. 🧵👇 1/8
12
65
282
27K
106
View Details
ShoagLab retweeted
New study with our amazing partners showing calorie restriction reduces aging associated mutation accumulation in mice is out in @CellCellPress. While lots of interventions increase mutations, here we show CR can actually slow normal aging-associated mutations genome-wide! Remarkable linkage between diet, genomic integrity, and lifespan. Interestingly, benefits were not uniformly distributed across the genome. cell.com/cell/abstract/… Led by @ShoagLab @giladevrony @VickyAcostaR @CircadianClocks @GronskaPeski @greenlab_utsw cc @PeterAttiaMD @NirBarzilaiMD @agingdoc1 @aubreydegrey @CharlesMBrenner @mkaeberlein @davidasinclair @UH_RE_Institute @caseccc @CaseUrology
This recent paper used Medicare linkage and evaluated 22 conditions attributed to PFS among 14,239 PCPT participants (7,087 finasteride, 7,152 placebo) followed for up to 20 years and found no significant associations with finasteride use. To us, this seems like really good evidence counter to recent narratives about PFS and suggest it is totally safe. Thoughts? @Justindubinmd @JoshuaHalpernMD @smsna_org @EricKleinMD @SBasourakos @MaleHealthDoc @jeshoag #UroSoMe #SBUR
This publication in @UrologyGold, by Ian Thompson’s group, builds on the landmark Prostate Cancer Prevention Trial (PCPT), in which ~18,000 men were randomized to finasteride vs. placebo. The trial found that finasteride decreased prostate cancer risk by ~25%, at the cost of detecting more high-grade cancers. nejm.org/doi/full/10.10… Long-term mortality linkage confirmed no increased risk of PCa death with finasteride. nejm.org/doi/pdf/10.105…
This week in our inaugural Journal Club, we are discussing a new paper that provides pretty compelling evidence that Post-Finasteride Syndrome (low libido, erectile dysfunction, depression, and cognitive complaints that persist after stopping finasteride) may be due to the “nocebo effect.”
Anyull Dayanna Bohorq... @Dayanna_Boho
190 Followers 652 Following Colombian 🇨🇴 l Research Fellow @CaseUrology | Fut Scientific Surgeon | Digital Illustrator | Great people have great values & great ethics.
Gilad Evrony @giladevrony
783 Followers 852 Following 🧬🧠 Center for Human Genetics & Genomics @nyulangone | @nyugrossman
Leonardo Kayat Bit.. @lkayat
1K Followers 1K Following Radiology (cancer and prostate imaging), Innovation, Rock'n Roll and Geek Culture. Professor, Vice-Chair of Innovation, Radiology - University Hospitals
Shany Picciotto @Shanypi1
15 Followers 401 Following Postdoc at CWRU. Studies somatic mutations and cancer
Dr. Nannan Thirumaval... @DrNannanT
1K Followers 703 Following Urologist @UHuroCLE @Caseurology specializing in #Menshealth #maleinfertility and #sexualdysfunction . Views my own.
Sean Fletcher @SeanFletcherMD
693 Followers 563 Following Urologic Oncology Fellow @MSKCancerCenter @UrologyMSK | Alum @Brady_Urology @HarvardMed @Yale
MaeEllie @EllieMa13190079
7 Followers 370 Following
Joshua Halpern, MD MS @JoshuaHalpernMD
863 Followers 433 Following Chief Scientific Officer + Regional Medical Director @_Posterity_ and Adjunct Assistant Professor @NM_Urology
Justin Dubin, MD @justindubinmd
8K Followers 3K Following Director of Men’s Sexual Health @ Baptist Health | Co-Host of The Man Up Podcast | Film/TV fanatic | IG: justindubinmd | Views expressed here are my own
Spyros Basourakos @SBasourakos
429 Followers 828 Following Urologic Oncology @CaseUrology | @UroOnc Fellowship at @MayoUrology | Residency at @WCMUrology | Former researcher at @MDAndersonNews | Views my own | 🇬🇷
Joshua Halpern, MD MS @JoshuaHalpernMD
863 Followers 433 Following Chief Scientific Officer + Regional Medical Director @_Posterity_ and Adjunct Assistant Professor @NM_Urology
Shany Picciotto @Shanypi1
15 Followers 401 Following Postdoc at CWRU. Studies somatic mutations and cancer
Gilad Evrony @giladevrony
783 Followers 852 Following 🧬🧠 Center for Human Genetics & Genomics @nyulangone | @nyugrossman
Justin Dubin, MD @justindubinmd
8K Followers 3K Following Director of Men’s Sexual Health @ Baptist Health | Co-Host of The Man Up Podcast | Film/TV fanatic | IG: justindubinmd | Views expressed here are my own
Daniel E Spratt @DrSpratticus
12K Followers 524 Following The comments & viewpoints are my own and are not endorsed or necessarily representative of UH CMC, CWRU, NCCN, FDA, NCI, or NRG. They are my personal opinion.
Spyros Basourakos @SBasourakos
429 Followers 828 Following Urologic Oncology @CaseUrology | @UroOnc Fellowship at @MayoUrology | Residency at @WCMUrology | Former researcher at @MDAndersonNews | Views my own | 🇬🇷
University Hospitals ... @CaseUrology
3K Followers 799 Following University Hospitals Cleveland & Case Western Reserve University are committed to enhancing human health through reimagined urologic care, training & research.
NephroPOCUS @NephroP
104K Followers 312 Following #POCUS #MedEd education 📖 | by Abhilash Koratala MD @KoraAbhi, “Echo-friendly” Nephrologist and Intensivist I Founding Member @POCUSIAPN | X≠ medical advice
Dr Khaled Ahmed Abuze... @khaledzeid
42K Followers 11 Following Clinical Radiologist from Egypt interested in Chest Imaging and trying to make it interesting to others everywhere
Eric Topol @EricTopol
831K Followers 689 Following physician-scientist, author of SUPER AGERS https://t.co/ZEdooyyJpP and Ground Truths: https://t.co/YhatcBT0hA
Samuel Hume @DrSamuelBHume
63K Followers 2K Following Doctor, scientist | Trying to speed up science and solve disease
André Martin Mansoor @AndreMansoor
79K Followers 394 Following Clinician. Author of #FrameworksForInternalMedicine. Cofounder https://t.co/iXxv1ZNGbj. https://t.co/1javJYYL59
Lea Alhilali, MD @teachplaygrub
95K Followers 173 Following Neuroradiologist @HRInstitute_AZ. @BarrowNeuro. Striving to make learning neuroimaging and anatomy fun. If I can make you laugh, I can make you learn.
Pathology Walker@Auto... @Patholwalker
39K Followers 3K Following Twting Pathology, Histology&Endoscopy, sometimes Mushroom. My pics are All CR Free with quoting source as conditions. Please use the pics as much as you'd like.
Tony Breu @tony_breu
108K Followers 894 Following Hospitalist, VA Boston. Assistant Professor, @harvardmed and @HMSbioethics. Co-host, @CuriousClinPod. Usually at #AMreport. Views are my own.
Vince Buffalo @vsbuffalo
50K Followers 3K Following Scientist. ♥s epidemiology, running, prob+stats, 🦀/🐫, fly fishing, greyhounds, backpacking. Author of book Bioinformatics Data Skills. All views my own.
Lior Pachter @lpachter
84K Followers 2K Following Bren Professor of Computational Biology @caltech. Blog at https://t.co/FFQzhEsmhi. Tweets represent my views, not my employer's. #methodsmatter
Mo Costandi @mocost
66K Followers 385 Following Neuroscientist/ freelance writer. Author of BODY AM I: THE NEW SCIENCE OF SELF-CONSCIOUSNESS https://t.co/zLBERRbfaY
Ethan J. Weiss @ethanjweiss
65K Followers 2K Following Scientist (metabolism) & Cardiologist (prevention); Latest @Marea_tx
Manolis Kellis @manoliskellis
64K Followers 4K Following Dissecting disease mechanism. Single-cell, Epigenomics, Regulatory Genomics, Disease Genetics, Brain, Cancer, Metabolism. @MIT Prof, @MIT_CSAIL, @BroadInstitute
Beth Shapiro @bonesandbugs
45K Followers 897 Following I'm an evolutionary (paleo)biologist & Chief Science Officer @colossal!
Kording Lab 🦖 @KordingLab
82K Followers 3K Following Konrad kording, @Penn Prof, deep learning, brains, #causality, rigor, https://t.co/tTJW05RRfa, https://t.co/qf7ZHxjaK1, Transdisciplinary optimist, Dad, Loves outdoors, 🦖
David Eagleman @davideagleman
99K Followers 1K Following Neuroscientist at Stanford, NYT bestselling author, Writer/host of The Brain. #1 Science Podcast: Inner Cosmos.
Pardis Sabeti @PardisSabeti
54K Followers 379 Following Professor @harvard @HarvardChanSPH @broadinstitute using genomics to impact infectious disease. Views are my own. @sabeti_lab @1000daysband
Fyodor Urnov @UrnovFyodor
51K Followers 526 Following Gene editor + Professor Molecular Therapeutics @berkeleyMCB + Director for Technology and Translation @igisci + @danahercorp Beacon for CRISPR Cures.
Prof. Nikolai Slavov @slavov_n
57K Followers 277 Following Mentor, scientist & engineer. Director of @ParallelSqTech. Having fun in @SlavovLab with single-cell proteomics & ribosomes. Organizer of @SCP_meeting
george church @geochurch
95K Followers 22 Following Professor @Harvard @MIT @PGorg @WyssInstitute tech dev: #CRISPR #NGS #BRAINi
Arjun Raj @arjunrajlab
64K Followers 2K Following Just another LLM. Tweets do not necessarily reflect the views of people in my lab or even my own views last week. https://t.co/fZAnUCqd12
Patrick Hsu @pdhsu
89K Followers 3K Following @ArcInstitute co-founder, @Stanford professor, @ThriveCapital investor | biology and ML research | 🇨🇦 prev @harvard @broadinstitute, Fast Grants
Dr. Angela Rasmussen @angie_rasmussen
516K Followers 8K Following Virologist. Co-EIC Vaccine. Jeopardy! loser. "Disreputable vaccine cheerleader." 🇺🇸in🇨🇦. Opinions mine. she/her
Bryan Johnson @bryan_johnson
2.2M Followers 688 Following Conquering death will be humanity’s greatest achievement. Founder Immortals, Blueprint, Kernel, Braintree Venmo.
Ben Greenfield @bengreenfield
243K Followers 119 Following Health & Performance Coach | NYTimes Bestselling Author | Host of the Boundless Life Podcast Now Streaming: https://t.co/fh3sZL5KgN
Dr Brad Stanfield @BradStanfieldMD
138K Followers 164 Following Primary Care Physician (GP). Get your personalized health plan: https://t.co/zBENBBnBa6
David Sinclair @davidasinclair
666K Followers 1K Following Professor researching why we age & how to reverse it. Author & host of Lifespan. Mission: Extend healthy life for all. Views are entirely his own. @joinlifespan
Gary Brecka @thegarybrecka
355K Followers 164 Following Human Biologist (non-physician) | Biohacker | Researcher #ThatsJustScience
Ben Smith @bensmithlive
299K Followers 335 Following Built a reputation reversing chronic health issues • Worked with 1,353 clients to heal their gut • Creating guided health recovery systems with AI
Peter Attia @PeterAttiaMD
665K Followers 136 Following
Thomas Dayspring @Drlipid
150K Followers 613 Following MD, FACP, MNLA - Clinical Lipidologist: Tweets/Re-Tweets do not represent endorsements/medical advice
Paul Saladino, MD @paulsaladinomd
488K Followers 110 Following Eat Food for Humans and thrive. Animal foods are essential for optimal human health. Food quality over calorie counting.
Andrew D. Huberman, P... @hubermanlab
1.9M Followers 2K Following Professor of Neurobiology and Ophthalmology at Stanford Medicine • Host of Huberman Lab • Focused on science and health research and public education
Dr. Rhonda Patrick @foundmyfitness
1.9M Followers 231 Following Ph.D in biomedical science interested in nutrition, brain & aging. Host of FoundMyFitness podcast https://t.co/rirQwqebxLYou might like
Elon Musk
@elonmusk
241.5M Followers
Barack Obama
@BarackObama
118.8M Followers
Cristiano Ronaldo
@Cristiano
114.5M Followers
Donald J. Trump
@realDonaldTrump
111.9M Followers
Rihanna
@rihanna
98.7M Followers
NASA
@NASA
92.3M Followers
Justin Bieber
@justinbieber
91.8M Followers
Taylor Swift
@taylorswift13
84.0M Followers
Lady Gaga
@ladygaga
75.5M Followers
Virat Kohli
@imVkohli
73.5M Followers
Kim Kardashian
@KimKardashian
70.9M Followers
YouTube
@YouTube
68.8M Followers
Neymar Jr
@neymarjr
66.5M Followers
Bill Gates
@BillGates
65.3M Followers
Selena Gomez
@selenagomez
63.1M Followers
CNN
@CNN
61.7M Followers
X
@X
60.7M Followers
CNN Breaking News
@cnnbrk
60.0M Followers
PMO India
@PMOIndia
58.4M Followers
LeBron James
@KingJames
55.4M Followers