Ping Lu @_PingLu
Peking University, Fuchou Tang lab. Single-cell multi-omics, RNA biology, cancer biology, bioinformatics Joined March 2019-
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NEW content online! Identification, functional insights and therapeutic targeting of EMT tumour states bit.ly/3IJ8haZ
NEW content online! The immune microenvironment of colorectal cancer bit.ly/4nBdL6q
New online! Is enhancer-driven gene regulation all wrapped up? bit.ly/46jTICr
Nature research paper: Fluctuating DNA methylation tracks cancer evolution at clinical scale go.nature.com/4n0zcOk
Therapeutic strategies aiming to enhance or inhibit regulatory T cell activity are being investigated in diseases including allergy, autoimmune disorders and cancer - find out more in this review by Megan Levings et al. nature.com/articles/s4157… rdcu.be/eDrL0
Excited to share our exploration @naturemethods into new horizons opening up in the era of low cost sequencing! 🔥 Deeper sequencing at WGS scale for PPM sensitivity of tumor informed MRD 🔥Duplex sequencing at WGS scale for plasma only exploration of ctDNA Check out thread 👇
Excited to share our exploration @naturemethods into new horizons opening up in the era of low cost sequencing! 🔥 Deeper sequencing at WGS scale for PPM sensitivity of tumor informed MRD 🔥Duplex sequencing at WGS scale for plasma only exploration of ctDNA Check out thread 👇
We're incredibly excited to share our new method, Paired-Damage-seq, out @naturemethods today! This technique allows us to jointly analyze oxidative DNA damage and SSBs with RNA, all at the single-cell level (1/5). nature.com/articles/s4159…
mRNA with engineered poly(A) tails produces prolonged higher levels of protein go.nature.com/3PzhhzM rdcu.be/ebqSg
🚨Today in @Nature, we show that mRNA mis-splicing creates clonal public neoantigens in solid cancers. An amazing collaboration between @UCSFCancer and @MSKCancerCenter driven by @DarwinKwok1 and co-led by Hideho Okada, @josephcostell14 and @KlebanoffLab. nature.com/articles/s4158…
Super excited to share our new study from the @JD_Buenrostro Lab in @Nature! We developed a computational method for tracking transcription factor and nucleosome binding using single-cell ATAC-seq and deep learning. Paper: nature.com/articles/s4158…
MethylTree developed by Wang and colleagues from @Westlake_Uni offers a non-invasive lineage tracing tool by using scBS-seq data. @ShouwenW @Li_Li_666 nature.com/articles/s4159…
Want to trace cell division histories in humans without gene editing? Here we develop MethylTree @naturemethods to use epimutations on DNA methylation for accurate lineage tracing across cell types, developmental stages and species. nature.com/articles/s4159…
The wait is over!! We are thrilled to announce that we have chosen Spatial Proteomics as 2024’s Method of the Year! 🥳 For more on Spatial Proteomics and a road map to this special issue, please see this month’s Editorial or read on in this thread. nature.com/articles/s4159…
1/ 🌍 Introducing our latest work DECIPHER, a new #bioinformatics #DeepLearning model for **disentangling** heterogeneous #singlecell spatial omics slices, just released on bioRxiv. doi.org/10.1101/2024.1…
(2/2)🌟 Reducing functionally defective old HSCs alleviates aging-related phenotypes in aged recipients. These findings shed light on the potential of targeted HSC interventions to combat aging effects. 🔗 Explore our results here: biorxiv.org/content/10.110…
(1/2)Our latest research reveals groundbreaking insights into hematopoietic stem cell (HSC) rejuvenation: 🌟 Transplantation of young HSCs rejuvenates aged recipients. 🌟 Even in older mice, youthful HSC subpopulations persist. biorxiv.org/content/10.110…
scNanoSeq-CUT&Tag employs long-read sequencing to profile histone modifications and DNA-binding proteins at the single-cell level, with a focus on previously underexplored complex genomic regions. nature.com/articles/s4159…
Super excited to be part of the LC2024 and meet all the wonderful people! @noush_joglekar #nanoporeconf #10YearsON
Don't miss Ping Lu at #nanoporeconf as she presents characterising RNA forms in colorectal cancer at the single-cell level. Explore how single-cell mutliomics is advancing our understanding of embryonic development and cancer. Learn more: bit.ly/3WqoIgR

gerry melino @melino_G
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Nature Medicine @NatureMedicine
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Cancer Cell @Cancer_Cell
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