Aleksandr Sviridov @_sviridov_
Longevity activist and software engineering lead. CTO at @GeroSense. Co-Founder of @SayForeverOrg. studies.gerosense.ai Belgrade, Serbia Joined January 2023-
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Found a curious paper that claims that most epigenetic clocks have a built-in circadian rhythm, showing the lowest biological age at midnight and the highest at noon, with a difference of up to several years within a day for the same person 😬 The study is extremely small, so…
Excellent overview of GeroSense Studies by @ArkadyMazin featuring @fedichev and me. Our website: studies.gerosense.ai iPhone app: apple.co/49HBdYm Android app waitlist: bit.ly/3JhXXTZ
Excellent overview of GeroSense Studies by @ArkadyMazin featuring @fedichev and me. Our website: studies.gerosense.ai iPhone app: apple.co/49HBdYm Android app waitlist: bit.ly/3JhXXTZ
I've become involved in several fascinating discussions here on X and in other places regarding whether a comprehensive theory of aging is necessary to fundamentally solve aging. What has caught my attention is the distinct perspective on what constitutes a "theory" across…
Интро лекция про индустрию старения / долголетия youtu.be/rQupDiVoqaA
📣Vitalism Foundation is hosting The Longevity State Conference, a curated first-of-its-kind event focused on longevity states & how to hasten their emergence. Join the best minds in Valencia, Spain May 13-15. Sign up & retweet if you want to live! longevitystate.com
This comment is worth highlighting. The paper on the impact of short-lived controls indeed shows different promising interventions that passed the 900-day rule according to data from DrugAge and GenAge databases. I don't know how rigorous were the studies for each intervention.
This comment is worth highlighting. The paper on the impact of short-lived controls indeed shows different promising interventions that passed the 900-day rule according to data from DrugAge and GenAge databases. I don't know how rigorous were the studies for each intervention.
Please read Andrew's comments on my recent thread. He provided a helpful counterbalance to the overly pessimistic tone of my piece.
Please read Andrew's comments on my recent thread. He provided a helpful counterbalance to the overly pessimistic tone of my piece.
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That’s true that reproducibility and questionable quality of controls are vast problems in aging research, both in genetic manipulation experiments and drug testing. In the Open Genes database, we have collected detailed experimental data specifically to be able to analyze the…
🧵 (1/6) Two years ago, when I only started digging into the current state of aging research, I was much more optimistic about our progress. I read articles like Laura Deming's Longevity FAQ, which lists "95 things that make mice live longer", and thought: "Well, at least we have…
So apparently if someone knows / guesses the name of your S3 bucket - even if it's private (!) - they can just bankrupt you by sending infinite PUT requests and there is nothing you can do about it. > requests get rejected > but AWS still counts it as a write operation against…
@_sviridov_ so dna methylation has a circadian frequency to it?
For those unfamiliar with me or my work: I'm dedicated to halting the aging process, and our company, Gero, is at the forefront of this endeavor. Our ultimate mission? Transform humans into a non-aging species Stay updated and join the longevity revolution – it's happening right…
Forget Bentleys, Dr. Rishi shows what luxury sounds like in our Standby Ambulance 🚑 #TomorrowBio #ASMR #StandbyAmbulance
@_sviridov_ drawing blood from the same person at the same time everyday under the same metabolic conditions (fasted for the same period of time) is going to be essential for teasing apart circadian rhythm dependent variables from not.
example 409 that age tests don’t measure what ppl think they are measuring
Found a curious paper that claims that most epigenetic clocks have a built-in circadian rhythm, showing the lowest biological age at midnight and the highest at noon, with a difference of up to several years within a day for the same person 😬 The study is extremely small, so…
@_sviridov_ CGMs will need a new function incorporating CEMs: continuous epigenetics monitors 😂
We're hiring talent to develop HSC therapies to improve lives of elderly patients. Please apply to our experimental PhD program if you dream about curing aging one day jobs.lever.co/retro/2f8f0ff6…
If people have not gathered in one place to create an extension of life, it means that people have not yet done anything to prolong life. What needs to be done to create a city of immortality? Keep a chronicle of events. Constantly talk about how things are going, what plans are…
@MikhailBatin Sounds pretty right, but for the truly interested billionaire, there's lots of room to invest in both. You can only get so many MRIs or colonoscopies. Research is a bottomless money pit. These guys are at least trying to make the selection process tractable, roadmap it, etc.
Not really. Hallmarks of Cancer were a list of necessary and sufficient components, but that's not the case for the aging hallmarks. Heck, they're not even a set of concepts at the same level of abstraction: 'intercellular signaling' covers half of what your body does.
I will be brief. These are the causes of aging. If we solve 3, we have 80% of aging solved.
Great week in aging biotech news thanks to Rubedo, Repair, & Gordian (🧵1/6): Rubedo raises $40M for its sophisticated senolytic platform w/ participation of many important investors (& me), notably being one of the first few investments by Hevolution. x.com/longevitytech/…
Rubedo lands $40m to advance senescence-targeting therapeutics into clinical trials... Longevity biotech @LifeRubedo plans Phase 1 #senotherapeutics trial this year as it seeks to keep people ‘biologically young.’ #longevity #investment #senescence longevity.technology/news/rubedo-la…
I looked at 100s of obituaries, and they all have universal tone of sorrow with phrases like “it’s with profound sadness we announce the passing of grandpa...". I haven't seen a single one that expressed joy by saying "we are delighted to report a passing of our grandpa. Death…
What could be more important (in our accelerating world) than the science of complexity? I see lots of beauty and practicality in it. We are starting with biology, as a sandbox, with a huge chance to buy ourselves precious time to build even more. Physics is the way to…
The complexity of fields such as biology, ecology, and economics often prompts skepticism towards the use of analytical tools. However, the study of complex systems in physics provides compelling examples where understanding the large-scale behavior requires surprisingly few…
The complexity of fields such as biology, ecology, and economics often prompts skepticism towards the use of analytical tools. However, the study of complex systems in physics provides compelling examples where understanding the large-scale behavior requires surprisingly few…
Nailed it. People love a good party, but learning enough to make smart choices on spending money or actually doing the hard research to actually solve the problem? Nah, that’s too much to ask… just buy some expensive olive oil and wait for someone else to do it.
Recently, I had a meeting at Dubai Mall, and while searching for the entrance, I accidentally found myself near the singing fountains during a musical performance. A crowd had gathered, and everyone started filming the event on their phones, watching in awe. Meanwhile, I stood…
From the thesis "we have nothing in life extension" it follows that "we must start all over again." Why do we have nothing? 1. We do not understand aging as a phenomenon. 2. We do not understand the evolution of aging (this remark alone is enough to assert that we are at…
Recently, I had a meeting at Dubai Mall, and while searching for the entrance, I accidentally found myself near the singing fountains during a musical performance. A crowd had gathered, and everyone started filming the event on their phones, watching in awe. Meanwhile, I stood…
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