Alexey Kadet @Alexey_Kadet
Chief Business Officer at Gero | Targeting root causes of age-related diseases linkedin.com/in/alex-kadet/ Menlo Park, CA Joined November 2021-
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This is hilarious 😂
I experience an unprecedented interest from pharma on our in-human target discovery platform at LSX World Congress in London. Such a pleasure to my heart! @fedichev I hope I won’t bring too much stuff to your plate back home 😅 @LSXLeaders
Ignoring aging doesn't make sense either. So many diseases (cancer, AD, T2D) are exacerbated with age. Understanding the biology of aging should be a key focus area of biology's future, especially yielding novel biology and targets for future drugs.
Ignoring aging doesn't make sense either. So many diseases (cancer, AD, T2D) are exacerbated with age. Understanding the biology of aging should be a key focus area of biology's future, especially yielding novel biology and targets for future drugs.
What could be more important (in our accelerating world) than the science of complexity? I see lots of beauty and practicality in it. We are starting with biology, as a sandbox, with a huge chance to buy ourselves precious time to build even more. Physics is the way to…
What could be more important (in our accelerating world) than the science of complexity? I see lots of beauty and practicality in it. We are starting with biology, as a sandbox, with a huge chance to buy ourselves precious time to build even more. Physics is the way to…
I can’t recommend something stronger than Omri’s content. Look and listen fellow (aspiring) founders. Good stuff.
I can’t recommend something stronger than Omri’s content. Look and listen fellow (aspiring) founders. Good stuff.
Absorbing what is around this week.
Peter is a good company, highly recommended.
Peter is a good company, highly recommended.
Epistemology is the essential pre-requisite for productive research.
Epistemology is the essential pre-requisite for productive research.
Human designs are limited because they have to be comprehensible. Evolved designs don't, they can be inscrutable labyrinthes of interdependent functionality. Oddly enough the chaotic mess ends up being the most robust and adaptive.
Human designs are limited because they have to be comprehensible. Evolved designs don't, they can be inscrutable labyrinthes of interdependent functionality. Oddly enough the chaotic mess ends up being the most robust and adaptive.
🔥New VitaDAO Aging Science Podcast alert: Peter Fedichev (@fedichev) & Jan Gruber discuss the science of aging, focusing on entropy and epigenetics. Tune in for insights into how these factors influence our understanding of aging. 👇 vitadao.com/blog-article/e…
Disease is just a word.
A pro-longevity Senator. We need more of them.
A pro-longevity Senator. We need more of them.
Kind thanks to everyone who came to our impromptu dinner chat last night - good vibes all around!
I am an angry guy, btw, speaking in these terms. Superficial people hate it. Authentic builders embrace it.
I am an angry guy, btw, speaking in these terms. Superficial people hate it. Authentic builders embrace it.
Oh wow, this thread is so good, check it out :)
Oh wow, this thread is so good, check it out :)
1/ Is there a credible plan to solve aging in our lifetimes? A plausible series of steps from where we are today, to a post-aging future? We looked, but we couldn’t find one. So we decided to build one. ↗️ See V1 of the Roadmap: longbiofellowship.org/roadmap
Next week I’m @hacking_aging in Singapore. Whom should I meet? DM/reach out
This is important for the field, imho.
This is important for the field, imho.
☺️
Gero (@hacking_aging) is in NYC for 3 days. Who should we meet? DM / reach out! @fedichev & I are traveling for the BIO event.
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BioAge @bioagelabs
4K Followers 0 Following BioAge is harnessing the biology of human aging to develop novel targets and therapies for metabolic diseases.@LidskyPeter @epsilonklm Of course. This is the most important questions. You can envision multiple strategies and some are employed by long lived creatures. We are working on a demonstration. And we know how increasing number of things that do not affect the entropic component of aging (even though…
thank you @epsilonklm , you are right = entropy increase in complex systems is not a consequence of being a close system or not, exchanging energy or not. It's practical issue of precision required to control the behavior of such system
The second law cannot be applied directly, but the increase in entropy could still explain aging. In my opinion, further differentiation is necessary here. 👇 The second law applies to thermodynamic isolated systems and states that entropy cannot decrease in such a system. This…
1/3 of Americans want to live forever I call that the @bryan_johnson effect
The most common character in tech is someone who was passionate about physics when they were young, and then went into software because there were no jobs in physics. But that has all changed - the future of technology innovation in atoms is broad beyond measure. Build hardware
@longevion Which "biohacks" move the needle? If there are ones, I'd be interested, but there's a chronic lack of evidence. Perhaps if the biohacker community could run actual efficacy trials? If we had validated biomarkers for aging? I'd like to see these things happen.
Last time, I cited a study analyzing the exponential increase in the size of the "useful" (or, God forbid, non-redundant) genome from the inception of life to the present day. The graph suggests that life's origin might have preceded the formation of our planet's solid crust.…
Cognitive aging is an overlooked reason on why slowing aging and rejuvenation are needed Not just our ECM becomes stiffer with age, our thoughts do too, and as compared to the skin, it has wide implications for our world
While @cz_binance may have broken US laws, he broke laws that shouldn’t exist in the first place. There are 144 million people in Russia. Transact with any of them and you can spend 20 years in prison. It’s ridiculous that hundreds of millions of people are not allowed access…
Proud to be backing Michael and Noah at Olden Labs. Super smart team with an ambitious vision to accelerate in vivo biosciences. Aging is the most complex technical challenge of our time. We can’t solve it with outdated bespoke methods. It’s time to ACCELERATE.
Excited to announce the launch of Olden Labs! A company building the world's first automated animal lab. Our goal is to radically accelerate animal research for mankind. longevity.technology/news/olden-lab…
"Live in such a way as to desire the eternity of that moment." - Professor Clovis de Barros Filho
I feel like I have free will but then I scroll past this and have literally no option but to waste four minutes on it
find the smiling raphael head
Forget Bentleys, Dr. Rishi shows what luxury sounds like in our Standby Ambulance 🚑 #TomorrowBio #ASMR #StandbyAmbulance
Found some new friends today in the computational universe:
It was wonderful to see so many of the world’s great entertainers coming together to celebrate some of the world’s great scientists at the 2024 Breakthrough Prize. youtube.com/live/XnNsH2g0g…
Found a curious paper that claims that most epigenetic clocks have a built-in circadian rhythm, showing the lowest biological age at midnight and the highest at noon, with a difference of up to several years within a day for the same person 😬 The study is extremely small, so…
Ignoring aging doesn't make sense either. So many diseases (cancer, AD, T2D) are exacerbated with age. Understanding the biology of aging should be a key focus area of biology's future, especially yielding novel biology and targets for future drugs.
Venki Ramakrishnan on aging-focused companies: “Many of these companies have highly distinguished scientists on their advisory boards - including some Nobel laureates who have no particular expertise in aging, apart from being old.”
IRA’s 9y pill penalty woke up many in biotech to consequences of public’s hatred of pharma, blamed for high OOP costs. Many now seek roadmap for fixing problem at its root. Countless tactics… TBD. The strategy is here: @NPLB_org @IAmBiotech @PhRMA rapport.bio/all-stories/er…
Looking worn from years of handling. Just posting to tell you to read this book. Or at the very least, read the cliffs notes.
Longevity Medicine 101
The best medicine I have found is to love a woman.
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